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Induction of permeabilization in HUVEC assessed as evans blue-bound albumin complex flux at 10 uM after 6 hrs by spectrophotometric method
Assay data:3 Tested
SummaryPubMed Citation
Reduction in CLP-induced sepsis lethality in C57BL/6 mouse assessed as increase in survival rate at 5.21 ug, iv administered first dose at 12 hrs post CLP challenge followed by second dose at 50 hrs post CLP challenge measured every 6 hrs after CLP challenge for 132 hrs
Assay data:1 Tested
Reduction in CLP-induced sepsis lethality in C57BL/6 mouse at 5.21 ug, iv administered at 12 hrs post CLP challenge measured every 6 hrs for 132 hrs
Reduction in LPS-induced leukocyte migration in mouse peritoneal cavity at 2 to 10 uM after 6 hrs by crystal violet staining-based light microscopic analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Toxicity in HUVEC cells assessed as effect on human neutrophil migration index at 10 uM after 6 hrs by crystal violet staining-based microscopic analysis
Reduction in LPS-induced human neutrophil migration index in HUVEC cells after 6 hrs by crystal violet staining-based microscopic analysis
Toxicity in HUVEC cells assessed as effect on human Vybrant DiD labelled neutrophil adhesion at 10 uM after 6 hrs by fluorescence analysis
Reduction in LPS-induced human Vybrant DiD labelled neutrophil adhesion in HUVEC cells after 6 hrs by fluorescence analysis
Cytotoxicity against HUVEC cells assessed as cell viability upto 30 uM by MTT assay
Vascular barrier protective effect in mouse assessed as inhibition of LPS induced peritoneal leakage of evans blue dye at 2 to 10 uM after 30 mins
Inhibition of LPS induced barrier disruption in HUVEC cells assessed as evans blue-bound albumin complex flux after 6 hrs by spectrophotometric method
Inhibition of LPS-induced paracellular gap formation in HUVEC cells assessed as formation of dense F-actin rings at 10 uM after 6 hrs by immunofluorescence staining assay
Antibacterial activity against Escherichia coli ATCC 25922 after 18 hrs by agar diffusion method
Assay data:12 Tested
Antibacterial activity against Bacillus subtilis NCTC 2116 after 18 hrs by agar diffusion method
Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 hrs by agar diffusion method
Inhibition of PLA2 in hemocytes of Spodoptera exigua fifth-instar larvae using pyrene-labeled phospholipid substrate by spectrofluorometry
Assay data:7 Tested
Inhibition of phenoloxidase activity in hemolymph of Spodoptera exigua fifth-instar larvae using DOPA substrate
Inhibition of immune responses in Spodoptera exigua fifth-instar larvae assessed as inhibition of hemocytic nodulation in response to Escherichia coli challenge by stereomicroscopy
Insecticidal activity against Plutella xylostella (diamondback moth) fourth-instar larvae fed on cabbage leaves soaked in compound solutions measured 48 hr post compound treatment by leaf-dipping method
Potentiation of 1000 ppm Bacillus thuringiensis-induced pathogenicity against Plutella xylostella (diamondback moth) fourth-instar larvae at 10000 ppm measured 48 hr post compound treatment
Assay data:7 Active, 7 Tested
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