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HIV Enzyme Data
Assay data:46810 Tested
Summary
HIV Cellular Data
Assay data:126857 Tested
Antiproliferative activity against human SW480 cells assessed as reduction in cell proliferation
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antiproliferative activity against human DLD-1 cells assessed as reduction in cell proliferation
High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
Antiproliferative activity against human MRC5 cells incubated for 72 hrs by MTT assay
Assay data:1 Active, 5 Tested
Antiproliferative activity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells incubated for 72 hrs by MTT assay
Assay data:5 Active, 5 Tested
Inhibition of KDM4A (unknown origin) measured by LANCEUltra assay
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of KDM4A (unknown origin) measured by formaldehyde dehydrogenase (FDH)-coupled fluorescence assay
Metal chelating activity assessed as Fe2+-compound complex formation by UV-visible spectrophotometry
Assay data:1 Active, 2 Tested
Inhibition of N-terminal His6-tagged TET2 (unknown origin) expressed in Escherichia coli assessed as reduction in 5-methylcytosine oxidation by measuring 5-carboxylcytosine level by FRET assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Binding affinity to Fe3+ assessed as formation of Fe3+-compound complex at 5 to 640 uM in presence of FeCl3 incubated for 3 hrs by Chrome Azurol S assay
Assay data:6 Active, 6 Tested
Inhibition of glutamate-induced oxidative stress in human SH-SY5Y cells assessed as reduction in superoxide radical formation at 10 uM measured after 4 hrs by DHE staining based fluorescence microscopy
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of glutamate-induced apoptosis in human SH-SY5Y cells assessed as caspase 3/7 activity at 10 uM incubated for 1 hr using Ac-DEVD-AMC as substrate by fluorescence analysis (Rvb = 100%)
Inhibition of glutamate-induced oxidative stress in human SH-SY5Y cells assessed as superoxide radical formation at 10 uM measured after 4 hrs by DHE staining based fluorescence spectrophotometry (Rvb = 100%)
Neuroprotective activity against glutamate-induced neurotoxicity in human SH-SY5Y cells assessed as cell death at 10 uM measured after 24 hrs by PI staining based assay (Rvb = 100%)
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