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Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
SummaryCompounds, Active
Synergistic anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability at 50 uM pretreated for 3 hrs followed by TRAIL stimulation measured after 24 hrs
Assay data:8 Tested
SummaryPubMed Citation
Synergistic anticancer activity against human MDA-MB-231 cells assessed as reduction in cell viability at 25 uM pretreated for 3 hrs followed by TRAIL stimulation measured after 24 hrs
A screen for small molecules that modulate mitochondrial supercomplex formation
Assay data:101 Active, 2017 Tested
SummaryCompounds, ActivePubMed Citation
Antimigratory activity in human DU145 cells by wound healing assay
Assay data:2 Tested
Induction of apoptosis in human DU145 cells assessed as increase in caspase-3/7 activity at 10 uM after 24 hrs in presence of TRAIL by Caspase-Glo 3/7 assay relative to control
Assay data:1 Tested
Induction of apoptosis in human DU145 cells assessed as increase in caspase-3/7 activity at 10 to 50 uM after 24 hrs by Caspase-Glo 3/7 assay
Assay data:1 Active, 1 Tested
Induction of apoptosis in human DU145 cells assessed as necrotic cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 1.6%)
Induction of apoptosis in human DU145 cells assessed as late apoptotic cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.2%)
Induction of apoptosis in human DU145 cells assessed as early apoptotic cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.3%)
Induction of apoptosis in human DU145 cells assessed as viable cells at 10 uM after 24 hrs in presence of TRAIL by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 97.9%)
Induction of apoptosis in human DU145 cells assessed as necrotic cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 1.6%)
Induction of apoptosis in human DU145 cells assessed as late apoptotic cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.2%)
Induction of apoptosis in human DU145 cells assessed as early apoptotic cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 0.3%)
Induction of apoptosis in human DU145 cells assessed as viable cells at 10 uM after 24 hrs by Annexin V-FITC/propidium iodide staining-based high content screening assay (Rvb = 97.9%)
Induction of apoptosis in human DU145 cells assessed as formation of apoptotic bodies at 10 uM after 24 hrs in presence of TRAIL by Hoechst 33258 staining-based fluorescence microscopic analysis
Induction of apoptosis in human DU145 cells assessed as formation of apoptotic bodies at 10 uM after 24 hrs by Hoechst 33258 staining-based fluorescence microscopic analysis
Induction of apoptosis in human DU145 cells assessed as chromatin shrinkage at 10 uM after 24 hrs in presence of TRAIL by Hoechst 33258 staining-based fluorescence microscopic analysis
Induction of apoptosis in human DU145 cells assessed as chromatin shrinkage at 10 uM after 24 hrs by Hoechst 33258 staining-based fluorescence microscopic analysis
Induction of apoptosis in human DU145 cells assessed as cell rounding at 10 uM after 24 hrs in presence of TRAIL by Hoechst 33258 staining-based fluorescence microscopic analysis
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