BioAssays for PubChem Compound (Select 445643) - PubChem BioAssay - NCBI

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Select item 20164081.

Immunosuppressive activity in BALB/c mouse allografted with C57 mouse cardiac tissue assessed as suppression of graft rejection by measuring graft median survival time at 4 mg/kg, IM

Source:: ChEMBL

Assay data:1 Tested

AID:: 2016408

Summary PubMed Citation

Select item 19756032.

Inhibition of human FKBP12 assessed as dissociation constant by Western blot analysis

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1975603

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19618783.

Binding affinity towards human HRH3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Histamine H3 receptor

Assay data:41 Active, 7 Activity ≤ 1 µM, 993 Tested

AID:: 1961878

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618714.

Antagonist activity at human TBXA2R in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Thromboxane A2 receptor

Assay data:8 Active, 1 Activity ≤ 1 µM, 71 Tested

AID:: 1961871

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618705.

Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:12 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 101 Tested

AID:: 1961870

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618696.

Compound was evaluated for inhibition of human ACHE in an vitro cell free assay measured by absorbance method

Source:: ChEMBL

Protein Target:: Acetylcholinesterase

Assay data:10 Active, 5 Activity ≤ 1 µM, 73 Tested

AID:: 1961869

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618687.

Binding affinity towards human ADRA1A in an in vitro assay with cellular components (NIBR assay) measured by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Alpha-1A adrenergic receptor

Assay data:49 Active, 29 Activity ≤ 1 µM, 231 Tested

AID:: 1961868

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618598.

Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting

Source:: ChEMBL

Protein Target:: D(1A) dopamine receptor

Assay data:35 Active, 19 Activity ≤ 1 µM, 305 Tested

AID:: 1961859

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618589.

Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Alpha-1A adrenergic receptor

Assay data:117 Active, 53 Activity ≤ 1 µM, 881 Tested

AID:: 1961858

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185710.

Binding affinity towards human CHRM2 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Muscarinic acetylcholine receptor M2

Assay data:58 Active, 2 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 301 Tested

AID:: 1961857

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185611.

Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: D(3) dopamine receptor

Assay data:176 Active, 1 Activity ≤ 1 nM, 87 Activity ≤ 1 µM, 1215 Tested

AID:: 1961856

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185512.

Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Assay data:49 Active, 5 Activity ≤ 1 µM, 1243 Tested

AID:: 1961855

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185313.

Binding affinity towards human HTR1A in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:56 Active, 33 Activity ≤ 1 µM, 377 Tested

AID:: 1961853

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185214.

Compound was evaluated for inhibition of human MAOA in an in vitro cell free assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Amine oxidase [flavin-containing] A

Assay data:28 Active, 4 Activity ≤ 1 µM, 1218 Tested

AID:: 1961852

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185115.

Binding affinity towards human OPRM1 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Mu-type opioid receptor

Assay data:60 Active, 9 Activity ≤ 1 µM, 766 Tested

AID:: 1961851

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196185016.

Binding affinity towards human ADRA2A in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Alpha-2A adrenergic receptor

Assay data:63 Active, 20 Activity ≤ 1 µM, 323 Tested

AID:: 1961850

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184917.

Binding affinity towards human SLC6A4 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent serotonin transporter

Assay data:148 Active, 75 Activity ≤ 1 µM, 1194 Tested

AID:: 1961849

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184818.

Binding affinity towards human SLC6A2 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent noradrenaline transporter

Assay data:123 Active, 40 Activity ≤ 1 µM, 1197 Tested

AID:: 1961848

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184719.

Binding affinity towards human SLC6A3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent dopamine transporter

Assay data:119 Active, 21 Activity ≤ 1 µM, 1213 Tested

AID:: 1961847

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196184620.

Binding affinity towards human TBXA2R in an in vitro assay with cellular components measured by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Thromboxane A2 receptor

Assay data:14 Active, 2 Activity ≤ 1 µM, 1022 Tested

AID:: 1961846

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (118)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (1)
BioAssays with compounds reported as validated chemical probes

Active Compounds (585)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (154)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (389)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (16)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (452)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (81)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (107)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (447)
BioAssays extracted from the literature
NIH MLP (70)
BioAssays deposited by the NIH Molecular Libraries Program
Other (326)
BioAssays deposited by other experimentalists

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