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Toxicity in beagle dog assessed as maximum tolerated dose
Assay data:1 Tested
SummaryPubMed Citation
Toxicity in beagle dog assessed as no-observed adverse effect level
Toxicity in mouse assessed as tissue injury at 5000 mg/kg, po measured after 14 days
Toxicity in mouse assessed as liver injury at 5000 mg/kg, po measured after 14 days
Toxicity in mouse assessed as mortality at 5000 mg/kg, po measured after 14 days
AUC (0 to infinity) in Sprague-Dawley rat assessed as clopidogrel thioacetate level at 24 umol/kg, po
Assay data:2 Tested
Half life in Sprague-Dawley rat assessed as clopidogrel thioacetate level at 24 umol/kg, po
Antiplatelet activity in Wistar rat assessed as inhibition of ADP-induced platelet aggregation at 3 mg/kg, po measured after 2 hrs by Born's method
Assay data:27 Tested
Drug metabolism in rat liver microsomes assessed as NADPH-dependent active metabolite glutathione adducts formation at 20 uM after 30 mins by LC-MS/MS analysis in presence of NADPH and GSH
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Drug metabolism in rat liver microsomes assessed as NADPH-dependent active metabolite glutathione adducts 1 formation at 20 uM after 30 mins by LC-MS/MS analysis
Drug metabolism in rat liver microsomes assessed as NADPH-dependent active metabolite glutathione adducts 3 formation at 20 uM after 30 mins by LC-MS/MS analysis
Drug metabolism in rat liver microsomes assessed as NADPH-dependent active metabolite glutathione adducts 2 formation at 20 uM after 30 mins by LC-MS/MS analysis
Drug metabolism in rat liver microsomes assessed as NADPH-dependent active metabolite glutathione adducts 4 formation at 20 uM after 30 mins by LC-MS/MS analysis
Cmax in Sprague-Dawley rat assessed as clopidogrel thioacetate level at 24 umol/kg, po
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Tmax in Sprague-Dawley rat assessed as clopidogrel thioacetate level at 24 umol/kg, po
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