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High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Binding affinity to Pseudomonas aeruginosa PAO1 LecA expressed in Escherichia coli assessed as dissociation constant by isothermal titration calorimetry
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
β-Gal Inhibitory Assay from Article 10.1074/jbc.M113.529529: "Structural basis of pharmacological chaperoning for human -galactosidase."
Assay data:1 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activity
Assay data:519 Active, 370620 Tested
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of CFTR in human intestinal organoids assessed as reduction in forskolin-induced oganoids swelling incubated for 4 hrs with cholera toxin followed by subsequent stimulation with 0.1 uM forskolin by calcein AM staining based confocal microscopy
Assay data:3 Tested
Inhibition of cholera toxin in human intestinal organoids assessed as reduction in oganoids swelling using cholera toxin pre-incubated with compound for 4 hrs before organoid stimulation with cholera toxin by calcein AM staining based confocal microscopy
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of HRP-tagged Vibrio cholerae cholera enterotoxin subunit B5 binding to GM1 coated plates using GM1os-beta-NAc-propargyl
Binding affinity to V5-His tagged FIBCD1 ecto-domain (54 to 461 residues) (unknown origin) expressed in HEK293 cells assessed as reduction in binding between FIBCD1 and acetylated BSA by ELISA
Assay data:16 Tested
SummaryRelated BioAssays by Target
Binding affinity to V5-His tagged FIBCD1 ecto-domain (54 to 461 residues) (unknown origin) assessed as reduction in binding between FIBCD1 and acetylated BSA at 50 mM by ELISA relative to control
Assay data:9 Tested
Binding affinity to jackfruit jacalin by SPR assay
Inhibition of Escherichia coli Heptosyltransferase I assessed as reduction in ADP release using ODLA and ADP-heptose substrates in presence of phospho(enol)pyruvate and NADH by pyruvate kinase and LDH based ADP/NADH coupling assay
Assay data:8 Tested
Inhibition of Escherichia coli Heptosyltransferase I assessed as reduction in ADP release at 1 mM using ODLA and ADP-heptose substrates in presence of phospho(enol)pyruvate and NADH by pyruvate kinase and LDH based ADP/NADH coupling assay
Assay data:21 Tested
Substrate activity at Escherichia coli Heptosyltransferase I assessed as ADP release at 100 uM using phospho(enol)pyruvate and NADH by pyruvate kinase and LDH based ADP/NADH coupling assay
qHTS Assay for Foot and Mouth Disease Virus Antivirals: Primary Screen against the MLPCN compound library
Assay data:1964 Active, 408697 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS for Suppressors of FUS Proteinopathy: Primary screen using FUS-linked yeast assay
Assay data:932 Active, 388864 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1
Assay data:13449 Active, 399619 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the parental adenocarcinoma cell KB-3-1
Assay data:5540 Active, 399561 Tested
qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: Primary Screen
Assay data:257 Active, 407462 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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