BioAssays, Active for PubChem Compound (Select 3039) - PubChem BioAssay - NCBI

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Select item 19635851.

p53 small molecule agonists, cell-based qHTS assay with human liver microsomes: Summary

Source:: Tox21

Protein Target:: tumor suppressor p53 [Homo sapiens]

Assay data:70 Active, 12 Activity ≤ 1 µM, 9667 Tested

AID:: 1963585

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19635802.

p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS cell viability counter screen

Source:: Tox21

Assay data:214 Active, 153 Activity ≤ 1 µM, 9667 Tested

AID:: 1963580

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19199703.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists, luciferase reporter gene qHTS assay in human keratinocytes: Summary

Source:: Tox21

Protein Target:: Nuclear factor (erythroid-derived 2)-like 2 [Homo sapiens]

Assay data:1038 Active, 9667 Tested

AID:: 1919970

Summary Compounds, Active Related BioAssays by Depositor Related BioAssays by Same Project

Select item 19199694.

Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes

Source:: Tox21

Protein Target:: Nuclear factor (erythroid-derived 2)-like 2 [Homo sapiens]

Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested

AID:: 1919969

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Same Project

Select item 16711995.

Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay

Source:: Tox21

Protein Target:: cytochrome P450, family 1, subfamily A, polypeptide 2

Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested

AID:: 1671199

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 13451996.

Drug repurposing screens with cells derived from glioblastoma tumor samples

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:1237 Active, 3 Activity ≤ 1 nM, 360 Activity ≤ 1 µM, 3733 Tested

AID:: 1345199

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 12515117.

Inhibition of Anopheles gambiae AChE G119S mutant after 10 mins by Ellman assay

Source:: ChEMBL

Assay data:9 Active, 3 Activity ≤ 1 µM, 24 Tested

AID:: 1251511

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 12515108.

Inhibition of recombinant Anopheles gambiae wild type AChE after 10 mins by Ellman assay

Source:: ChEMBL

Protein Target:: Acetylcholinesterase

Assay data:22 Active, 18 Activity ≤ 1 µM, 24 Tested

AID:: 1251510

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12515099.

Inhibition of recombinant Anopheles gambiae AChE G119S mutant after 60 mins by Ellman assay

Source:: ChEMBL

Assay data:12 Active, 5 Activity ≤ 1 µM, 24 Tested

AID:: 1251509

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 125150810.

Inhibition of recombinant Anopheles gambiae wild type AChE after 60 mins by Ellman assay

Source:: ChEMBL

Protein Target:: Acetylcholinesterase

Assay data:22 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 24 Tested

AID:: 1251508

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 125150711.

Inhibition of recombinant human AChE after 60 mins by Ellman assay

Source:: ChEMBL

Protein Target:: Acetylcholinesterase

Assay data:19 Active, 17 Activity ≤ 1 µM, 24 Tested

AID:: 1251507

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 125150612.

Inhibition of recombinant human AChE after 10 mins by Ellman assay

Source:: ChEMBL

Protein Target:: Acetylcholinesterase

Assay data:20 Active, 15 Activity ≤ 1 µM, 24 Tested

AID:: 1251506

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 125941113.

CCRIS carcinogenicity studies

Source:: Chemical Carcinogenesis Research Information System (CCRIS)

Assay data:1139 Active, 1767 Tested

AID:: 1259411

Summary Compounds, Active

Select item 125940814.

GENE-TOX mutagenicity studies

Source:: Genetic Toxicology Data Bank (GENE-TOX)

Assay data:1995 Active, 3214 Tested

AID:: 1259408

Summary Compounds, Active

Select item 125940715.

CCRIS mutagenicity studies

Source:: Chemical Carcinogenesis Research Information System (CCRIS)

Assay data:4929 Active, 8266 Tested

AID:: 1259407

Summary Compounds, Active

Select item 110193216.

Insecticidal activity against Rhyzopertha dominica after 24 hr

Source:: ChEMBL

Assay data:12 Active, 14 Tested

AID:: 1101932

Summary Compounds, Active PubMed Citation

Select item 110193117.

Insecticidal activity against Musca domestica (house fly) after 24 hr

Source:: ChEMBL

Assay data:14 Active, 6 Activity ≤ 1 µM, 14 Tested

AID:: 1101931

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 74321918.

qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary

Source:: Tox21

Protein Target:: nuclear factor erythroid 2-related factor 2 isoform 1

Assay data:1147 Active, 1 Activity ≤ 1 nM, 122 Activity ≤ 1 µM, 9305 Tested

AID:: 743219

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 74319919.

qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary

Source:: Tox21

Protein Target:: peroxisome proliferator activated receptor gamma

Assay data:430 Active, 9305 Tested

AID:: 743199

Summary Compounds, Active PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

Select item 74307820.

qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary

Source:: Tox21

Assay data:433 Active, 1 Activity ≤ 1 nM, 156 Activity ≤ 1 µM, 10486 Tested

AID:: 743078

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Same Project Related BioAssays by Target

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Target

Proteins (16)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (47)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (13)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (29)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (6)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (29)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (14)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (8)
BioAssays extracted from the literature
NIH MLP (9)
BioAssays deposited by the NIH Molecular Libraries Program
Other (25)
BioAssays deposited by other experimentalists

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