BioAssays, Active for PubChem Compound (Select 3822) - PubChem BioAssay - NCBI

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Select item 20118051.

Displacement of [3H]-ketanserin from bovine cortex 5-HT2B receptor assessed as inhibition constant incubated for 30 mins by liquid scintillation spectroscopy analysis

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 2011805

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19779562.

Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:5 Active, 4 Activity ≤ 1 µM, 6 Tested

AID:: 1977956

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19640973.

5-HT2 Receptor Assays from US Patent US20240279226: "ERGOLINE-DERIVED AGONISTS OF THE 5-HT2A RECEPTOR"

Source:: BindingDB

Protein Targets:: 5-hydroxytryptamine receptor 2A; ...
Total:: 2

Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1964097

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19635964.

Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: cytochrome P450 3A7 [Homo sapiens]

Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested

AID:: 1963596

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 19618585.

Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Alpha-1A adrenergic receptor

Assay data:117 Active, 53 Activity ≤ 1 µM, 881 Tested

AID:: 1961858

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618566.

Binding affinity towards human DRD3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: D(3) dopamine receptor

Assay data:176 Active, 1 Activity ≤ 1 nM, 87 Activity ≤ 1 µM, 1215 Tested

AID:: 1961856

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618537.

Binding affinity towards human HTR1A in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:56 Active, 33 Activity ≤ 1 µM, 377 Tested

AID:: 1961853

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618368.

Compound was evaluated for inhibition of rat Slc18a2 in an ex vivo assay measured by radioactivity method

Source:: ChEMBL

Protein Target:: Synaptic vesicular amine transporter

Assay data:39 Active, 1 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 82 Tested

AID:: 1961836

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19617859.

Compound was evaluated for inhibition of human KCNH2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily H member 2

Assay data:353 Active, 116 Activity ≤ 1 µM, 1804 Tested

AID:: 1961785

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196178010.

Binding affinity towards human HTR2C in an in vitro assay with cellular components measured by radioactivity method

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:123 Active, 1 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 1199 Tested

AID:: 1961780

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196177511.

Binding affinity towards human HTR2A in an in vitro assay with cellular components measured by membrane filtration

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:140 Active, 4 Activity ≤ 1 nM, 75 Activity ≤ 1 µM, 414 Tested

AID:: 1961775

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196176612.

Binding affinity towards human HRH1 in an in vitro assay measured by filtration

Source:: ChEMBL

Protein Target:: Histamine H1 receptor

Assay data:151 Active, 1 Activity ≤ 1 nM, 90 Activity ≤ 1 µM, 1239 Tested

AID:: 1961766

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196173813.

Binding affinity towards human DRD2 in an in vitro assay with cellular components measured by membrane filtration, scintillation proximity assay

Source:: ChEMBL

Protein Target:: D(2) dopamine receptor

Assay data:153 Active, 2 Activity ≤ 1 nM, 73 Activity ≤ 1 µM, 1228 Tested

AID:: 1961738

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196173614.

Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting

Source:: ChEMBL

Protein Target:: D(1A) dopamine receptor

Assay data:117 Active, 49 Activity ≤ 1 µM, 927 Tested

AID:: 1961736

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196169515.

Compound was evaluated for inhibition of human ADRA2C in an in vitro assay with cellular components measured by membrane filtration

Source:: ChEMBL

Protein Target:: Alpha-2C adrenergic receptor

Assay data:195 Active, 66 Activity ≤ 1 µM, 1241 Tested

AID:: 1961695

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196168916.

Binding affinity towards human ADRA1A in an in vitro assay with cellular components (NIBR assay) measured by scintillation proximity assay

Source:: ChEMBL

Protein Target:: Alpha-1A adrenergic receptor

Assay data:150 Active, 65 Activity ≤ 1 µM, 699 Tested

AID:: 1961689

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196168817.

Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Alpha-1A adrenergic receptor

Assay data:99 Active, 56 Activity ≤ 1 µM, 800 Tested

AID:: 1961688

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 195995418.

Inhibition of 5-HT2A (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1959954

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 191987119.

Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: RPMI8226_ATCC cell viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:685 Active, 11 Activity ≤ 1 nM, 288 Activity ≤ 1 µM, 1912 Tested

AID:: 1919871

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 191986420.

Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: U266_ATCC cell viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:779 Active, 12 Activity ≤ 1 nM, 367 Activity ≤ 1 µM, 1911 Tested

AID:: 1919864

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

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Proteins (35)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (202)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (73)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (158)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (158)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (4)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (168)
BioAssays extracted from the literature
NIH MLP (12)
BioAssays deposited by the NIH Molecular Libraries Program
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BioAssays deposited by other experimentalists

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