BioAssays, Active for PubChem Compound (Select 44259) - PubChem BioAssay - NCBI

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Items: 1 to 20 of 3102

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Select item 20339791.

Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:8 Active, 1 Activity ≤ 1 µM, 14 Tested

AID:: 2033979

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 20339782.

Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:9 Active, 1 Activity ≤ 1 µM, 14 Tested

AID:: 2033978

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 20339773.

Cytotoxicity against human PC-3 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay

Source:: ChEMBL

Assay data:10 Active, 5 Activity ≤ 1 µM, 14 Tested

AID:: 2033977

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 20334074.

Inhibition of N-terminal His10-StrepII tagged human ROCK2 catalytic domain (1 to 553 residues) expressed in Sf9 insect cells by HTRF assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:49 Active, 81 Activity ≤ 1 µM, 90 Tested

AID:: 2033407

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 20326455.

Inhibition of FGFR-1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo kinase assay

Source:: ChEMBL

Protein Target:: Fibroblast growth factor receptor 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 2032645

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 20325296.

Inhibition of GSK3beta (unknown origin) incubated for 20 mins in presence of 33P-ATP

Source:: ChEMBL

Protein Target:: Glycogen synthase kinase-3 beta

Assay data:9 Active, 3 Activity ≤ 1 µM, 10 Tested

AID:: 2032529

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 20325287.

Inhibition of JNK1 (unknown origin) incubated for 20 mins in presence of 33P-ATP

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 8

Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested

AID:: 2032528

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 20325278.

Inhibition of JNK2 (unknown origin) incubated for 20 mins in presence of 33P-ATP

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 9

Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested

AID:: 2032527

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 20319169.

Inhibition of human JNK2 incubated for 40 mins in presence of ATP and [gamma33P-ATP] by scintillation counting method

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 9

Assay data:10 Active, 10 Activity ≤ 1 µM, 11 Tested

AID:: 2031916

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 203191510.

Inhibition of human JNK1 incubated for 40 mins in presence of ATP and [gamma33P-ATP] by scintillation counting method

Source:: ChEMBL

Protein Target:: Mitogen-activated protein kinase 8

Assay data:10 Active, 9 Activity ≤ 1 µM, 11 Tested

AID:: 2031915

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 202628611.

Antiproliferative activity against human SR cells assessed as inhibition of cell growth incubated for 2 to 4 hrs by MTT assay

Source:: ChEMBL

Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested

AID:: 2026286

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 201904812.

Antiprotozoal activity against Tritrichomonas foetus KV-1 strain assessed as inhibition of protozoal growth measured after 72 hrs under anaerobic conditions

Source:: ChEMBL

Assay data:2 Active, 4 Tested

AID:: 2019048

Summary Compounds, Active PubMed Citation

Select item 201904713.

Cytotoxicity against human NFF cells incubated for 72 hrs by resazurin staining based microplate reader assay

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 2019047

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 201904514.

Cytotoxicity against human DU-145 cells incubated for 72 hrs by resazurin staining based microplate reader assay

Source:: ChEMBL

Assay data:1 Active, 4 Tested

AID:: 2019045

Summary Compounds, Active PubMed Citation

Select item 200938815.

Antiproliferative activity against human MDA-MB-468 cells assessed inhibition of cell growth incubated for 72 hrs by CCK-8 assay

Source:: ChEMBL

Assay data:11 Active, 6 Activity ≤ 1 µM, 11 Tested

AID:: 2009388

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 200818216.

Inhibition of RSK1 (unknown origin)

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-1

Assay data:8 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 8 Tested

AID:: 2008182

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 200641617.

Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth by MTT assay

Source:: ChEMBL

Assay data:9 Active, 18 Tested

AID:: 2006416

Summary Compounds, Active PubMed Citation

Select item 200641518.

Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth by MTT assay

Source:: ChEMBL

Assay data:9 Active, 1 Activity ≤ 1 µM, 18 Tested

AID:: 2006415

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 200641419.

Inhibition of CDK6 (unknown origin) incubated for 60 mins in presence of ATP by luminescence based analysis

Source:: ChEMBL

Protein Target:: Cyclin-dependent kinase 6

Assay data:16 Active, 14 Activity ≤ 1 µM, 16 Tested

AID:: 2006414

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 200641320.

Inhibition of CDK4 (unknown origin) incubated for 60 mins in presence of ATP by luminescence based analysis

Source:: ChEMBL

Protein Target:: Cyclin-dependent kinase 4

Assay data:15 Active, 12 Activity ≤ 1 µM, 15 Tested

AID:: 2006413

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (37)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (1)
BioAssays with compounds reported as validated chemical probes

Active Compounds (3,102)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (542)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (2,787)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (2,802)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (6)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (22)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (2,793)
BioAssays extracted from the literature
NIH MLP (24)
BioAssays deposited by the NIH Molecular Libraries Program
Other (285)
BioAssays deposited by other experimentalists

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