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Inhibition of TbetaR-1 (unknown origin)
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY5_PLB cell viability assay
Assay data:980 Active, 10 Activity ≤ 1 nM, 428 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS34_JCRB cell viability assay
Assay data:581 Active, 20 Activity ≤ 1 nM, 384 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1R_ATCC cell viability assay
Assay data:822 Active, 12 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: JJN3_DSMZ cell viability assay
Assay data:743 Active, 23 Activity ≤ 1 nM, 495 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMM1_JCRB cell viability assay
Assay data:606 Active, 18 Activity ≤ 1 nM, 360 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: FR4_PLB cell viability assay
Assay data:609 Active, 23 Activity ≤ 1 nM, 283 Activity ≤ 1 µM, 1912 Tested
Induction of cardiac differentiation in mouse ESC transfected with Myh6-GFP treated for 48 hrs and measured after 4 to 6 days by imaging analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibitory Activity Toward ALK5 Enzyme from US Patent US11466003: "Nitrogenous heterocyclic aromatic compound, preparation method therefor, pharmaceutical composition thereof, and application thereof"
Assay data:57 Active, 53 Activity ≤ 1 µM, 60 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Activity Inhibition from US Patent US11447490: "Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof"
Assay data:25 Active, 24 Activity ≤ 1 µM, 25 Tested
LanthaScreen Eu Kinase Binding Assay from US Patent US10865384: "2,4,5-tri-substituted azole-based casein kinase 1 inhibitors as inducers for cardiomyogenesis"
Assay data:20 Active, 16 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Antifibrotic activity in rat NRK-52E cells assessed as decrease in TGFbeta1-induced cellular morphological changes measured after 24 hrs
Z'-LYTE: ACVR1B (ALK4), Direct Format, kinase activity assay, coupled enzyme activity measurement method, detected via fluorescence resonance energy transfer
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of TGFbeta receptor in mouse NMuMG cells assessed as suppression of TGFbeta1-induced calpain activity by measuring Filamin-A levels at 1 to 10 uM incubated for 24 to 72 hrs by Western blot analysis
SummaryCompounds, Active
Inhibition of TGFbeta receptor in mouse NMuMG cells assessed as suppression of TGFbeta1-induced SMAD2 phosphorylation at 1 to 10 uM incubated for 24 to 72 hrs by Western blot analysis
Inhibition of TGFbeta receptor in mouse NMuMG cells assessed as suppression of TGFbeta1-induced EMT by measuring alpha-SMA expression at 1 to 10 uM incubated for 24 to 72 hrs by Western blot analysis
Inhibition of recombinant human N-terminal GST-tagged TGFbeta1 receptor (80 to end residues) expressed in baculovirus infected Sf9 insect cells using casein as substrate measured after 2 hrs by ADP-Glo assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 3 expression at 10 uM measured after 12 hrs by Western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in collagen 1 expression at 10 uM measured after 12 hrs by Western blot analysis
Inhibition of TGFbeta1 receptor in TGFbeta1-stimulated Sprague-Dawley rat cardiac fibroblasts assessed as reduction in alpha-SMA expression at 10 uM measured after 12 hrs by Western blot analysis
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