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Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by fluorescence method
Assay data:80 Active, 33 Activity ≤ 1 µM, 924 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:96 Active, 35 Activity ≤ 1 µM, 927 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-taurocholate transport into vesicles incubated for 5 mins by Topcount based rapid filtration method
Assay data:115 Active, 1 Activity ≤ 1 µM, 620 Tested
CCRIS mutagenicity studies
Assay data:4929 Active, 8266 Tested
SummaryCompounds, Active
The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. Cell Systems Volume 1, Issue 6, p383-395
Assay data:2021 Active, 5518 Tested
SummaryCompounds, ActiveRelated BioAssays by Same Project
High Throughput Screening for Foot and Mouth Disease Virus Antivirals
Assay data:5052 Active, 2 Activity ≤ 1 nM, 3045 Activity ≤ 1 µM, 408696 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Ki values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
Assay data:66 Active, 16 Activity ≤ 1 µM, 66 Tested
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B3-transfected CHO cells
Assay data:63 Active, 10 Activity ≤ 1 µM, 66 Tested
Ki values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
Assay data:66 Active, 33 Activity ≤ 1 µM, 66 Tested
pIC50 values for sodium fluorescein (10 uM) uptake in OATP1B1-transfected CHO cells
Assay data:64 Active, 21 Activity ≤ 1 µM, 67 Tested
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity
Assay data:5173 Active, 301246 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Antiradical activity assessed as DPPH radical scavenging activity at 1050 uM by spectrophotometry relative to control
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 24 hrs by luciferase reporter assay
Assay data:2 Active, 2 Tested
Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/3-5B/KE/poly cells after 72 hrs by luciferase reporter assay
Assay data:4 Active, 4 Tested
Antiviral activity against HCV assessed as suppression of HCV RNA replication in ORN/C-5B/KE/poly cells after 72 hrs by luciferase reporter assay
Antiviral activity against HCV assessed as inhibition of HCV RNA replication in OR6 cells after 72 hrs by luciferase reporter assay
Assay data:2 Active, 6 Tested
Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells after 48 hrs
Assay data:51 Active, 51 Activity ≤ 1 µM, 51 Tested
TR-FRET-based primary biochemical high-throughput screening assay to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization
Assay data:998 Active, 302755 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database
Assay data:1216 Active, 1216 Tested
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