BioAssays, Active for PubChem Compound (Select 572) - PubChem BioAssay - NCBI

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Select item 19634981.

HTS to identify compounds that affect the blood-brain barrier permeability in vitro

Source:: Burek Lab, Department of Anaesthesiology, Intensive Care, Emergency and Pain Med, University Hospital Wuerzburg

Assay data:419 Active, 1260 Tested

AID:: 1963498

Summary Compounds, Active

Select item 18010442.

DXR Inhibition Assay for Fosmidomycin from Article 10.1016/j.bioorg.2015.02.008: "Flavonoids: true or promiscuous inhibitors of enzyme? The case of deoxyxylulose phosphate reductoisomerase."

Source:: BindingDB

Protein Targets:: 1-deoxy-D-xylulose 5-phosphate reductoisomerase; ...
Total:: 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1801044

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 16252783.

Antimalarial activity against Plasmodium falciparum Dd2 assessed as reduction in parasite viability by [3H]-hypoxanthine incorporation assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1625278

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 13348374.

Inhibition of Escherichia coli His6-tagged DXR preincubated for 2 mins in presence of NADPH followed by DXP substrate addition

Source:: ChEMBL

Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested

AID:: 1334837

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 12035455.

Antibacterial activity against Escherichia coli K-12 by two-fold broth microdilution method

Source:: ChEMBL

Assay data:1 Active, 13 Tested

AID:: 1203545

Summary Compounds, Active PubMed Citation

Select item 12035436.

Antibacterial activity against Escherichia coli ATCC 8739 by two-fold broth microdilution method

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 13 Tested

AID:: 1203543

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 12035427.

Inhibition of recombinant Plasmodium falciparum Dxr expressed in Escherichia coli C43(DE3) using DOXP as substrate assessed as NADPH oxidation by spectrophotometric analysis

Source:: ChEMBL

Assay data:6 Active, 3 Activity ≤ 1 µM, 10 Tested

AID:: 1203542

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 12035418.

Inhibition of recombinant Escherichia coli Dxr expressed in Escherichia coli BL21 CodonPlus (DE3)-RIL cells using DOXP as substrate assessed as NADPH oxidation preincubated for 5 mins with NADPH followed by substrate addition by spectrophotometric analysis

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 µM, 10 Tested

AID:: 1203541

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 11978659.

Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum D10 incubated for 3 days by HRP2 detection based ELISA method

Source:: ChEMBL

Assay data:21 Active, 19 Activity ≤ 1 µM, 25 Tested

AID:: 1197865

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 119786410.

Antiplasmodial activity against blood stage forms of chloroquine-sensitive Plasmodium falciparum 3D7 incubated for 3 days by HRP2 detection based ELISA method

Source:: ChEMBL

Assay data:24 Active, 24 Activity ≤ 1 µM, 25 Tested

AID:: 1197864

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 119786311.

Antiplasmodial activity against blood stage forms of multidrug-resistant Plasmodium falciparum Dd2 incubated for 3 days by HRP2 detection based ELISA method

Source:: ChEMBL

Assay data:24 Active, 24 Activity ≤ 1 µM, 25 Tested

AID:: 1197863

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 119786212.

Inhibition of recombinant Plasmodium falciparum IspC using [3,4,5-13C3]1-Deoxy-D-xylulose 5-phosphate substrate by photometric assay

Source:: ChEMBL

Assay data:5 Active, 5 Activity ≤ 1 µM, 25 Tested

AID:: 1197862

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 119527013.

Antimalarial activity against chloroquine and mefloquine-resistant Plasmodium falciparum Dd2 after 48 hrs by SYBR Green I assay

Source:: ChEMBL

Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested

AID:: 1195270

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 119373414.

Antimalarial activity against MRA-150, chloroquine, pyrimethamine, mefloquine-resistant asexual blood stage Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay

Source:: ChEMBL

Assay data:19 Active, 8 Activity ≤ 1 µM, 31 Tested

AID:: 1193734

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 117905815.

Inhibition of His-tagged Escherichia coli DXR pre-incubated for 2 mins before reaction initiation in presence of 160 uM NADPH in absence of 0.01% Triton X100

Source:: ChEMBL

Protein Target:: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Assay data:7 Active, 1 Activity ≤ 1 µM, 8 Tested

AID:: 1179058

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 116370716.

Inhibition of Escherichia coli Dxr

Source:: ChEMBL

Protein Target:: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1163707

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 111957717.

Inhibition of Escherichia coli IspC

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1119577

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 111311218.

Inhibition of Arabidopsis thaliana IspC expressed in Escherichia coli after 40 min by spectrophotometric analysis

Source:: ChEMBL

Protein Target:: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1113112

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 107749219.

Inhibition of His-tagged Mycobacterium tuberculosis DXR expressed in Escherichia coli BL21(DE3) using DXP as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by NADPH and substrate addition by spectrophotometric analysis

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested

AID:: 1077492

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 106349720.

Inhibition of Mycobacterium tuberculosis Dxr

Source:: ChEMBL

Protein Target:: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested

AID:: 1063497

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (100)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (2)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (67)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (69)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (97)
BioAssays extracted from the literature
Other (3)
BioAssays deposited by other experimentalists

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