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Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2225 Active, 268 Activity ≤ 1 µM, 9667 Tested
Chaperone activity at recombinant human C-terminal FLAG-tagged pendrin P123S mutant expressed in HEK293 cells assessed as increase in localization of protein mutant in plasma membrane at 1 to 30 mM after 12 hrs by DAPI staining based immunofluorescence microscopic analysis
Assay data:7 Active, 17 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of human recombinant DDO expressed in Escherichia coli BL21(DE3) using D-Asp by Lineweaver-Burk plot analysis
Assay data:3 Active, 3 Tested
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary
Assay data:1147 Active, 1 Activity ≤ 1 nM, 122 Activity ≤ 1 µM, 9305 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in presence of fumarate
Assay data:1 Active, 3 Tested
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in absence of fumarate
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in absence of fumarate
SummaryCompounds, ActivePubMed Citation
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in presence of fumarate
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
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