BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 20118051.

Displacement of [3H]-ketanserin from bovine cortex 5-HT2B receptor assessed as inhibition constant incubated for 30 mins by liquid scintillation spectroscopy analysis

Source:: ChEMBL

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 2011805

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19779562.

Displacement of [3H]ketanserin from Sprague-Dawley rat 5-HT2A receptor assessed as inhibition constant measured after 60 mins by competitive binding assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:5 Active, 4 Activity ≤ 1 µM, 6 Tested

AID:: 1977956

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19640973.

5-HT2 Receptor Assays from US Patent US20240279226: "ERGOLINE-DERIVED AGONISTS OF THE 5-HT2A RECEPTOR"

Source:: BindingDB

Protein Targets:: 5-hydroxytryptamine receptor 2A; ...
Total:: 2

Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1964097

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19618584.

Antagonist activity at human ADRA1A in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Alpha-1A adrenergic receptor

Assay data:117 Active, 53 Activity ≤ 1 µM, 881 Tested

AID:: 1961858

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618455.

Antagonist activity at human TBXA2R in an in vitro cell-based assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Thromboxane A2 receptor

Assay data:34 Active, 15 Activity ≤ 1 µM, 906 Tested

AID:: 1961845

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618446.

Agonist activity at human TBXA2R in an in vitro cell-based assay (CRO assay) measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Thromboxane A2 receptor

Assay data:13 Active, 8 Activity ≤ 1 µM, 927 Tested

AID:: 1961844

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618407.

Binding affinity towards human SLC6A4 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent serotonin transporter

Assay data:99 Active, 36 Activity ≤ 1 µM, 927 Tested

AID:: 1961840

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618398.

Binding affinity towards human SLC6A3 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent dopamine transporter

Assay data:128 Active, 38 Activity ≤ 1 µM, 927 Tested

AID:: 1961839

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19618389.

Binding affinity towards human SLC6A2 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Sodium-dependent noradrenaline transporter

Assay data:137 Active, 27 Activity ≤ 1 µM, 927 Tested

AID:: 1961838

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196183610.

Compound was evaluated for inhibition of rat Slc18a2 in an ex vivo assay measured by radioactivity method

Source:: ChEMBL

Protein Target:: Synaptic vesicular amine transporter

Assay data:39 Active, 1 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 82 Tested

AID:: 1961836

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196182811.

Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by fluorescence method

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 1

Assay data:80 Active, 33 Activity ≤ 1 µM, 924 Tested

AID:: 1961828

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196182612.

Compound was evaluated for inhibition of human PTGS1 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Prostaglandin G/H synthase 1

Assay data:96 Active, 35 Activity ≤ 1 µM, 927 Tested

AID:: 1961826

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196182013.

Binding affinity towards human PGR in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Progesterone receptor

Assay data:87 Active, 51 Activity ≤ 1 µM, 927 Tested

AID:: 1961820

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196181414.

Compound was evaluated for inhibition of human PDE4A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cAMP-specific 3',5'-cyclic phosphodiesterase 4A

Assay data:46 Active, 10 Activity ≤ 1 µM, 927 Tested

AID:: 1961814

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196181315.

Compound was evaluated for inhibition of human PDE3A in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: cGMP-inhibited 3',5'-cyclic phosphodiesterase A

Assay data:15 Active, 6 Activity ≤ 1 µM, 927 Tested

AID:: 1961813

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196181216.

Binding affinity towards human OPRM1 in an in vitro assay with cellular components measured by scintillation counting

Source:: ChEMBL

Protein Target:: Mu-type opioid receptor

Assay data:117 Active, 24 Activity ≤ 1 µM, 927 Tested

AID:: 1961812

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196178717.

Compound was evaluated for inhibition of human MAOA in an in vitro cell free assay measured by fluorescence spectroscopy

Source:: ChEMBL

Protein Target:: Amine oxidase [flavin-containing] A

Assay data:13 Active, 5 Activity ≤ 1 µM, 927 Tested

AID:: 1961787

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196178618.

Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:19 Active, 11 Activity ≤ 1 µM, 692 Tested

AID:: 1961786

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196178019.

Binding affinity towards human HTR2C in an in vitro assay with cellular components measured by radioactivity method

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:123 Active, 1 Activity ≤ 1 nM, 48 Activity ≤ 1 µM, 1199 Tested

AID:: 1961780

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196177720.

Agonist activity at human HTR2B in an in vitro cell-based assay (CRO assay) measured by time-resolved fluorescence resonance energy transfer method

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2B

Assay data:3 Active, 5 Activity ≤ 1 µM, 927 Tested

AID:: 1961777

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (6)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (163)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (75)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (166)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (166)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (146)
BioAssays extracted from the literature
NIH MLP (15)
BioAssays deposited by the NIH Molecular Libraries Program
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BioAssays deposited by other experimentalists

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