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transactivation assay from US Patent US10544075: "Derivatives of sobetirome"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TR Receptor Ligand Binding Assay from Article 10.1016/s1074-5521(98)90168-5: "A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor."
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 mins assessed as biotin-GRIP1 peptide recruitment by HTRF assay
Assay data:18 Active, 11 Activity ≤ 1 µM, 22 Tested
Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 mins assessed as biotin-GRIP1 peptide recruitment by HTRF assay
Assay data:22 Active, 15 Activity ≤ 1 µM, 22 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Binding affinity to human TRbeta1
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human TRalpha1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay
Assay data:27 Active, 6 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay
Assay data:27 Active, 2 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 27 Tested
Binding affinity of compound was determined against thyroid hormone receptor beta 1
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Binding affinity against human Thyroid hormone receptor beta 1 (hTRbeta1) using radiolabeled T3
Assay data:7 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity of compound was determined against Thyroid hormone receptor alpha1
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
Binding affinity against human Thyroid hormone receptor alpha-1 (hTRalpha1) using radiolabeled T3
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Half-maximum activation of human Thyroid hormone receptor alpha-1 (hTRalpha1)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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