BioAssays, activity concentration at/below 1 nM for PubChem Compound ( - PubChem BioAssay - NCBI

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Select item 20057581.

Partial agonist activity at human 5-HT2AR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 2005758

Summary Related BioAssays by Target

Select item 20057512.

Partial agonist activity at human 5-HT2CR expressed in human Flp-In-T-REx-293 cells assessed as increase in calcium flux incubated for 60 mins followed by incubation for 30 mins in dark by Flou-4 dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:18 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 18 Tested

AID:: 2005751

Summary Related BioAssays by Target

Select item 16860913.

Agonist activity at human 5-HT2C INI receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:9 Active, 1 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1686091

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16860794.

Agonist activity at human 5-HT2C receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 direct dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:42 Active, 2 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 44 Tested

AID:: 1686079

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16757085.

Agonist activity at 5-HT2B receptor (unknown origin) by calcium mobilization assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2B

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1675708

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16481816.

Agonist activity at mouse 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1648181

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16481797.

Agonist activity at human 5-HT2A receptor expressed in Flp-In T-REx 293 cells assessed as induction of Gq-mediated calcium flux incubated for 1 hr by Flou4-AM dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1648179

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16270818.

Displacement of [3H]-8-OH-DPAT from human 5-HT1A receptor expressed in CHOK1 cell membranes after 30 mins by liquid scintillation spectrometry

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 1A

Assay data:16 Active, 2 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 16 Tested

AID:: 1627081

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16068899.

Agonist activity at human 5HT2C receptor stably expressed in HEK293 cells co-expressing Gq assessed as induction of calcium mobilization measured at 1 sec interval for 60 secs by Fluo-4 calcium dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:4 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 6 Tested

AID:: 1606889

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 156529410.

Agonist activity at recombinant human 5HT2A receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2A

Assay data:13 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 17 Tested

AID:: 1565294

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 156529111.

Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2B

Assay data:11 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 17 Tested

AID:: 1565291

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 156528812.

Agonist activity at recombinant human unedited 5HT2C receptor isoform INI expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fluo-4 dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:15 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 17 Tested

AID:: 1565288

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 144606713.

Agonist activity at human 5-HT2C-INI receptor isoform expressed in Flp-IN HEK293 cells assessed as induction of Gq-mediated calcium flux measured every second for 5 mins by Fluo-4 dye based FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:33 Active, 1 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 33 Tested

AID:: 1446067

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 143398414.

Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells after 120 mins by scintillation counting

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1433984

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 133636215.

Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHO cells measured after 120 mins by scintillation counting method

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1336362

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 128566316.

Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1285663

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 119973217.

Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2B

Assay data:27 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 27 Tested

AID:: 1199732

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 119972918.

Agonist activity at human 5-HT2C receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 2C

Assay data:36 Active, 1 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 36 Tested

AID:: 1199729

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 119632719.

Displacement of [3H]LSD from human 5-HT7 receptor expressed in CHO cells

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1196327

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 115268120.

Displacement of [3H]LSD from human recombinant 5-HT7 receptor expressed in CHO cells

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1152681

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (39)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (39)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (39)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (41)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (41)
BioAssays extracted from the literature

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