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Antiviral activity against HBV infected in ETV/3TC-resistant HepG2.A64 cells assessed as reduction in viral replication
Assay data:1 Active, 1 Tested
Summary
Antiviral activity against wild type HBV infected in HepG2.2.15 cells assessed as reduction in viral replication
Antiviral activity against Hepatitis B virus infected in C57BL/6J mouse assessed as reduction in HBsAg level in serum at 25 mg/kg/day, po for 18 days by ELISA
Assay data:1 Tested
Antiviral activity against Hepatitis B virus infected in C57BL/6J mouse assessed as reduction in HBcAg expression in serum at 25 mg/kg/day, po for 18 days by immunohistochemistry
Antiviral activity against Hepatitis B virus infected in C57BL/6J mouse assessed as inhibition of viral DNA level in serum at 25 mg/kg/day, po for 18 days by qPCR analysis
Antiviral activity against Hepatitis B virus infected in human HLCZ01 cells assessed as reduction in HBsAg level at 0.03 to 3 uM incubated for 6 days by ELISA
Antiviral activity against Hepatitis B virus infected in human HLCZ01 cells assessed as inhibition of HBV virion production by measuring inhibition of viral DNA replication incubated for 6 days by qPCR analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of fluorescent-labeled capsid assembly in Hepatitis B virus incubated for 1 hr by fluorescence based analysis
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryRelated BioAssays by Target
Antiviral activity against Hepatitis B virus infected in human HePAD38 cells assessed as inhibition of viral DNA replication by qPCR analysis
Assay data:61 Active, 40 Activity ≤ 1 µM, 63 Tested
Inhibition of HBV replication transfected in human HepG2.2.15 cells assessed as assessed as induction of total core protein degradation in cell lysate at upto 10 uM incubated for 5 days by SDS-PAGE analysis
Assay data:1 Active, 2 Tested
Inhibition of HBV replication transfected in human HepG2.2.15 cells assessed as assessed as induction of capsid degradation in cell lysate at upto 10 uM incubated for 5 days by SDS-PAGE analysis
Inhibition of HBV replication transfected in human HepG2.2.15 cells assessed as inhibition of encapsidated DNA formation in cell lysate incubated for 5 days by SDS-PAGE analysis
Assay data:2 Tested
Inhibition of HBV Cp150 dimer assembly assessed as formation of large abnormal particles at 20 uM incubated for 2 hrs by transmission electron microscopy
In vivo antiviral activity against AAV encapsidated HBV infected in C57BL/6 mouse model assessed as reduction in serum HBV DNA level at 20 mg/kg, BID measured on day 6 by quantitative real-time PCR analysis
In vivo antiviral activity against AAV encapsidated HBV infected in C57BL/6 mouse model assessed as log reduction in serum HBV DNA level at 20 mg/kg, BID measured on day 4 by quantitative real-time PCR analysis
In vivo antiviral activity against AAV encapsidated HBV infected in C57BL/6 mouse model assessed as log reduction in serum HBV DNA level at 20 mg/kg, BID measured on day 2 by quantitative real-time PCR analysis
Resistance index, ratio of EC50 for wild type Hepatitis B virus to EC50 for Hepatitis B virus harboring M2041 transfected in human HepG2 cells measured after 6 days by qPCR analysis
Resistance index, ratio of EC50 for wild type Hepatitis B virus to EC50 for Hepatitis B virus harboring L180M/M204 V/T184G/S2021 transfected in human HepG2 cells measured after 6 days by qPCR analysis
Resistance index, ratio of EC50 for wild type Hepatitis B virus to EC50 for Hepatitis B virus harboring L180M/M204 V/M250 V/1169T transfected in human HepG2 cells measured after 6 days by qPCR analysis
Resistance index, ratio of EC50 for wild type Hepatitis B virus to EC50 for Hepatitis B virus harboring L180M/M204 V/S202G transfected in human HepG2 cells measured after 6 days by qPCR analysis
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