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Binding affinity to GFP expressing Listeria monocytogenes EGD-e PrfA expressed in Escherichia coli assessed as inhibition of bacterial uptake in human Caco2 cells at 20 uM incubated for 4 hrs by flow cytometric method relative to (R)-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylic acid
Assay data:17 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to GFP expressing Listeria monocytogenes EGD-e PrfA expressed in Escherichia coli assessed as inhibition of bacterial uptake in human Caco2 cells at 1 uM incubated for 4 hrs by flow cytometric method relative to control
Assay data:1 Tested
Inhibition of PrfA in Listeria monocytogenes EGD-e assessed as downregulation of ActA expression at 1 uM by Western blot method
Assay data:4 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PrfA in Listeria monocytogenes EGD-e assessed as downregulation of LLO expression at 1 uM by Western blot method
Inhibition of PrfA in Listeria monocytogenes EGD-e assessed as downregulation of ActA expression at 10 uM by Western blot method
Assay data:3 Active, 4 Tested
Inhibition of PrfA in Listeria monocytogenes EGD-e assessed as downregulation of LLO expression at 10 uM by Western blot method
Growth inhibition of Listeria monocytogenes EGD-e BUG1600 after overnight incubation by resazurin based assay
Assay data:35 Tested
SummaryPubMed Citation
Ratio of MIC wild-type Listeria monocytogenes EGD-e Serovar 1/2a to MIC for telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a
Assay data:4 Tested
Antibacterial activity against 10'5 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a after 16 hrs by by two fold serial dilution method
Antibacterial activity against 10'5 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a after 20 hrs by by two fold serial dilution method
Antibacterial activity against 10'5 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a after 16 hrs by by two fold serial dilution method
Antibacterial activity against 10'5 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a after 20 hrs by by two fold serial dilution method
Antibacterial activity against 10'7 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a at 5 ug after 16 hrs by disk diffusion assay
Antibacterial activity against 10'7 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a at 1 ug after 16 hrs by disk diffusion assay
Antibacterial activity against 10'7 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a at 10 ug after 16 hrs by disk diffusion assay
Antibacterial activity against 10'7 CFU/ml telA-deficient Listeria monocytogenes EGD-e Serovar 1/2a at 30 ug after 16 hrs by disk diffusion assay
Assay data:2 Tested
Antibacterial activity against 10'7 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a at 5 ug after 16 hrs by disk diffusion assay
Antibacterial activity against 10'7 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a at 1 ug after 16 hrs by disk diffusion assay
Antibacterial activity against 10'7 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a at 10 ug after 16 hrs by disk diffusion assay
Antibacterial activity against 10'7 CFU/ml wild-type Listeria monocytogenes EGD-e Serovar 1/2a at 30 ug after 16 hrs by disk diffusion assay
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