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Inhibition of Staphylococcus aureus USA300 LAC quorum sensing system Agr assessed as reduction in hla transcription at 2.9 to 16 uM after 5 hrs by RNA protect cell reagent based qRT-PCR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Staphylococcus aureus USA300 LAC quorum sensing system AgrA assessed as reduction in psma transcription at 2.9 to 16 uM after 5 hrs by RNA protect cell reagent based qRT-PCR analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Staphylococcus aureus USA300 LAC quorum sensing system AgrA assessed as reduction in RNA3 transcription at 9 to 16 uM after 5 hrs by RNA protect cell reagent based qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 LAC quorum sensing system Agr assessed as reduction in AIP production measured after 5 hrs by UPLC-MS analysis
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of AddAB in Staphylococcus aureus USA300 JE2 transformed with pCN34 PrecA-gfp reporter plasmid assessed as inhibition of SOS response by measuring reduction in green fluorescence per cell at 66 uM measured at 15 mins interval for 17 hrs by GFP reporter gene assay
Inhibition of AddAB in Staphylococcus aureus USA300 JE2 transformed with pCN34 PrecA-gfp reporter plasmid assessed as growth inhibition by measuring increase in green fluorescence per cell at 66 uM measured at 15 mins interval for 17 hrs by GFP reporter gene assay
Inhibition of AddAB in Staphylococcus aureus USA300 JE2 transformed with pCN34 PrecA-gfp reporter plasmid assessed as decrease in cell number at 66 uM measured at 15 mins interval for 17 hrs by GFP reporter gene assay
Assay data:2 Active, 2 Tested
Ratio of MBC to MIC for methicillin/erythromycin/tetracycline-resistant Staphylococcus aureus USA300 NRS384 clinical isolate
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of Staphylococcus aureus USA300 GFP-fused SaeRS at 20 uM after 8 hrs by fluorescence-based assay
Assay data:6 Tested
Inhibition of methicillin-resistant Staphylococcus aureus USA300 SaeRS Tn551 deletion mutant assessed as reduction in alpha-hemolysin mediated hemolysis of human erythrocytes at 15 uM after 8 hrs by ELISA relative to control
Inhibition of methicillin-resistant Staphylococcus aureus USA300 SaeRS Tn551 deletion mutant assessed as reduction in alpha-hemolysin mediated hemolysis of human erythrocytes at 8 uM after 8 hrs by ELISA relative to control
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in staphylokinase gene expression at 10 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in gamma-hemolysin gene expression at 10 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in aureolysin gene expression at 10 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in alpha-hemolysin gene expression at 10 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in staphylokinase gene expression at 8 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in gamma-hemolysin gene expression at 8 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in aureolysin gene expression at 8 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS assessed as reduction in alpha-hemolysin gene expression at 8 uM after 6 hrs by qRT-PCR analysis
Inhibition of Staphylococcus aureus USA300 SaeRS expressed in Escherichia coli BL21(DE3) assessed as reduction in alpha-hemolysin mediated hemolysis in human erythrocytes after 8 hrs by ELISA
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