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Antiprotozoal activity against Leishmania mexicana infected in mouse J774 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antileishmanial activity against Leishmania mexicana promastigotes assessed as parasite growth inhibition
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antileishmanial activity against Leishmania mexicana promastigote infected in mouse J774A.1 cells assessed as inhibition of intracellular amastigotes growth measured after 24 hrs incubation by Renilla luciferase assay system
Antileishmanial activity against Leishmania mexicana promastigote infected in mouse J774A.1 cells assessed as inhibition of intracellular amastigotes growth measured after 30 mins incubation by Renilla luciferase assay system
Antileishmanial activity against Leishmania mexicana promastigote infected in mouse J774A.1 cells assessed as inhibition of intracellular amastigotes growth measured after 72 hrs by Renilla luciferase assay system
Assay data:31 Active, 33 Activity ≤ 1 µM, 34 Tested
Antileishmanial activity against promastigote form of Leishmania mexicana
Assay data:2 Tested
SummaryPubMed Citation
Antileishmanial activity against Leishmania Mexicana injected in BALB/c mouse foot pad lesion model assessed as inhibition of lesion size progression during drug administration at 10 mg/kg, ip treated for 10 consecutive days
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antileishmanial activity against Leishmania mexicana promastigote infected in mouse J774A.1 cells assessed as inhibition of intracellular amastigotes growth at 10 uM measured after 72 hrs by Renilla luciferase assay system relative to control
Assay data:3 Tested
Binding affinity to Leishmania mexicana PK
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Leishmania mexicana PYK (Asn75, Il61, Ser362, Arg73, Gln329 residues) incubated for 15 mins
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antileishmanial activity against Leishmania mexicana 227 assessed as inhibition of parasite viability
Antileishmanial activity against Leishmania mexicana assessed as inhibition of parasite growth
Antileishmanial activity against mammalian stage Leishmania mexicana MNYC/BZ/62/M379 axenic amastigotes assessed as inhibition of promastigote growth incubated for 24 hrs by alamar blue assay
Assay data:2 Active, 2 Tested
Antileishmanial activity against promastigote form of Leishmania mexicana assessed as inhibition of parasite growth measured for 10 days by Neubauer counting chamber based analysis
Inhibition of recombinant Leishmania mexicana CPB2.8 delta CTE at 20 uM
Antileishmanial activity against promastigote form of Leishmania mexicana MHOM/BZ/82/Bel21 measured for 7 days by cell counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of Leishmania mexicana CPB delta CTE mutant using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by substrate addition by fluorimetric assay
Assay data:35 Active, 2 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 36 Tested
Antileishmanial activity against axenic amastigote stage of Leishmania mexicana (MNYC/BZ/62/M379) assessed as induction of parasite killing incubated for 24 hrs by alamar blue dye based fluorescence analysis
Assay data:10 Active, 1 Activity ≤ 1 µM, 57 Tested
Antileishmanial activity against axenic amastigote stage of Leishmania mexicana (MNYC/BZ/62/M379) infected in mouse RAW264.7 cells assessed as induction of parasite killing incubated for 24 hrs by alamar blue dye based fluorescence analysis
Inhibition of Leishmania mexicana rCPB3.0 H84Y mutant assessed as inhibition constant for uncompetitive inhibition using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Burk double reciprocal plot analysis
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