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Inhibition of Plasmodium falciparum NF54 HDAC using extract measured after 60 mins by fluorescence assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of tubulin polymerization in asexual blood stage Plasmodium falciparum NF54
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of tubulin polymerization in asexual stage (III) Plasmodium falciparum NF54 early gametocytes at 2400 nM incubated for 24 hrs by tubulin tracker Oregon Green staining method
Assay data:2 Active, 2 Tested
Inhibition of tubulin polymerization in asexual stage (II) Plasmodium falciparum NF54 early gametocytes at 2400 nM incubated for 24 hrs by tubulin tracker Oregon Green staining method
Inhibition of tubulin polymerization in asexual stage (I) Plasmodium falciparum NF54 early gametocytes at 2400 nM incubated for 24 hrs by tubulin tracker Oregon Green staining method
Assay data:2 Tested
SummaryPubMed Citation
Inhibition of tubulin polymerization in asexual blood stage Plasmodium falciparum NF54 at 600 nM incubated for 24 hrs by tubulin tracker Oregon Green staining method
Inhibition of Plasmodium falciparum NF54 PI4K
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Stability of the compound assessed as Plasmodium falciparum NF54 esterase-mediated fusidic acid release at 0.5 uM up to 48 hrs by LC-MS/MS analysis
Assay data:3 Active, 3 Tested
Inhibition of beta hematin formation in ring stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as decrease in haemozoin level at 0.5 to 3 times IC50 after 36 hrs by UV-vis spectra analysis
Assay data:1 Tested
Inhibition of beta hematin formation in ring stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as increase in free heme level at 0.5 to 3 times IC50 after 36 hrs by UV-vis spectra analysis
Inhibition of beta hematin formation in ring stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as increase in free heme level after 36 hrs by UV-vis spectra analysis
Inhibition of beta hematin formation in ring stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as decrease in haemozoin level after 36 hrs by UV-vis spectra analysis
Inhibition of voltage-gated calcium channel in Plasmodium flaciparum NF54 cells assessed as potentiation of choloroquine induced antimalarial activity by measuring chloroquine IC50 in presence of compound at 1 uM
Assay data:8 Tested
Inhibition of Plasmodium falciparum NF54 IspE
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
OSM: Late stage gametocytes. IC50 values determined from 21 point dose response curves. Avery Group Griffith.
Assay data:6 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_DryPowder_Activity
Assay data:5 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Inhibition of Plasmodium falcipirum NF54 Measured in Cell-Based System Using Plate Reader - 2138-11_Inhibitor_Dose_CherryPick_Activity
Assay data:5 Active, 20 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Inhibition of hemozoin formation after 48 hrs in chloroquine-sensitive Plasmodium falciparum NF54
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of hemozoin formation after 48 hrs against chloroquine-sensitive Plasmodium falciparum NF54 at 10 to 100 uM by spectrophotometry
Assay data:3 Tested
Inhibition of recombinant deoxyhypusine synthase in Plasmodium falciparum NF54
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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