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MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultivated in 100 ul with 96-well plates at 2.5% and 5% hematocrits. The parasites were cultivated in triplicate for 4 days without replacement of the medium for each concentration of the compound. On the fourth day of culture, lysis buffer containing 2x SGI was added and 50% inhibitory concentration (IC50) values were calculated.
Assay data:215 Active, 55 Activity ≤ 1 µM, 360 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
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