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Inhibition of Drosophila melanogaster Spastin N527C mutant (209 to 758 residues) in presence of ATP by NADH-coupled fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of wild-type Drosophila melanogaster Spastin (209 to 758 residues) in presence of ATP by NADH-coupled fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Effect on Drosophila melanogaster Nav1 expressed in Xenopus laevis oocytes at 10 uM at holding potential of -90 mV by patch clamp electrophysiology
Assay data:1 Tested
SummaryPubMed Citation
Invivo inhibition of AChE in Elav-GAL4/UAS-Abeta42 hybrid Drosophila melanogaster assessed as reduction in intracephalic AChE levels at 0.1 to 10 uM by HPLC analysis
Assay data:3 Active, 3 Tested
Invivo inhibition of AChE in Elav-GAL4/UAS-Abeta42 hybrid Drosophila melanogaster assessed as reduction in intracephalic AChE levels by HPLC analysis
Assay data:10 Tested
Cytotoxicity against Drosophila melanogaster S2 cells assessed as reduction in cell viability at 10 ug/ml by WST8 assay
Assay data:3 Tested
Inhibition of FASN in one day old PINK1 mutant containing Drosophila melanogaster assessed as rescue of defective flight at 0.1 to 300 uM dosed with food incubated for 72 hrs
Summary
Inhibition of FASN in one day old PINK1 mutant containing Drosophila melanogaster assessed as rescue of defective flight at 100 to 300 uM dosed with food incubated for 72 hrs
Mutagenicity in Drosophila melanogaster somatic cells assessed as mutant spot frequencies in ST crosses at 1 mM by SMART assay
Toxicity in Drosophila melanogaster assessed as survival rate at 0.25 to 1 mM
Assay data:6 Tested
Mutagenicity in Drosophila melanogaster somatic cells assessed as frequency of clone formation in ST crosses at 0.25 to 1 mM by SMART assay
Assay data:5 Tested
Mutagenicity in Drosophila melanogaster somatic cells assessed as frequency of clone formation in HB crosses at 0.25 to 1 mM by SMART assay
Mutagenicity in Drosophila melanogaster somatic cells assessed as mutant spot frequencies in HB crosses at 1 mM by SMART assay
Inhibition of total calcium oxalate crystal area in Oregon R Drosophila melanogaster malpighian tubule model at 50 uM treated for 24 hrs with calcium oxalate by DIC microscopy
Inhibition of calcium oxalate crystal size in Oregon R Drosophila melanogaster malpighian tubule model at 50 uM treated for 24 hrs with calcium oxalate by DIC microscopy
Inhibition of calcium oxalate crystallization in Oregon R Drosophila melanogaster malpighian tubule model at 50 uM treated for 24 hrs with calcium oxalate by DIC microscopy
Inhibition of total calcium oxalate crystal area in Oregon R Drosophila melanogaster malpighian tubule model at 100 uM preincubated with test compound alone for 20 mins followed by addition of calcium oxalate along with test compound measured after 1 hr by DIC microscopy
Inhibition of calcium oxalate crystal size in Oregon R Drosophila melanogaster malpighian tubule model at 100 uM preincubated with test compound alone for 20 mins followed by addition of calcium oxalate along with test compound measured after 1 hr by DIC microscopy
Inhibition of calcium oxalate crystallization in Oregon R Drosophila melanogaster malpighian tubule model at 100 uM preincubated with test compound alone for 20 mins followed by addition of calcium oxalate along with test compound measured after 1 hr by DIC microscopy
Inhibition of fruit fly non-muscle myosin 2
SummaryPubMed CitationRelated BioAssays by Target
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