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Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as increase of liver alkaline phosphatase activity at 15 mg/kg, po qd for 48 weeks
Assay data:4 Tested
SummaryPubMed Citation
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as increase of liver aspartate aminotransferase activity at 15 mg/kg, po qd for 48 weeks
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as increase of liver alanine aminotransferase activity at 15 mg/kg, po qd for 48 weeks
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as increase of serum gamma-glutamyltransferase activity at 15 mg/kg, po qd for 48 weeks
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as increase of liver sorbitol dehydrogenase activity at 15 mg/kg, po qd measured on 28 to 48 weeks on 48 week study
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as increase of liver alanine aminotransferase activity at 15 mg/kg, po qd measured on 4 to 24 weeks on 48 week study
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as increase of liver sorbitol dehydrogenase activity at 15 mg/kg, po qd measured on 4 to 24 weeks on 48 week study
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as effect on hematological parameters at 15 mg/kg, po qd for 48 weeks measured up to 60 weeks
Toxicity in Woodchuck hepatitis virus infected woodchuck assessed as change in body weight at 15 mg/kg, po qd for 48 weeks measured up to 60 weeks
Cmax in woodchuck hepatitis virus-negative woodchucks at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
Assay data:1 Tested
Cmax in woodchuck hepatitis virus-negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose
Cmax in woodchuck hepatitis virus-negative woodchucks at 33.3 mg/kg, iv administered as single dose
Cmax in woodchuck hepatitis virus-negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg iv followed by after 4 weeks washout period administered 33.3 mg/kg, po
Oral bioavailability in woodchuck hepatitis virus-negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
AUC in iv dosed woodchuck assessed as serum 9-(beta-D-1,3-dioxolan-4-yl)guanine level
AUC in po dosed woodchuck assessed as serum 9-(beta-D-1,3-dioxolan-4-yl)guanine level
Toxicity in woodchuck hepatitis virus chronically infected woodchuck assessed as serum alanine aminotransferase level at 30 mg/kg/day, po after 4 weeks
Toxicity in woodchuck hepatitis virus chronically infected woodchuck assessed as serum sorbitol dehydrogenase level at 30 mg/kg/day, po after 4 weeks
Toxicity in woodchuck hepatitis virus chronically infected woodchucks assessed as change in body weight administered once daily for 4 weeks
Terminal elimination half life in woodchuck hepatitis virus -negative woodchucks assessed as 9-(beta-D-1,3-dioxolan-4-yl)guanine at 33.3 mg/kg, iv administered as single dose followed by dose of 33.3 mg/kg, po after 4 weeks washout period
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