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Select item 101059581.

Mitochondrial creatine kinase 1 regulates the cell cycle in non-small cell lung cancer via activation of cyclin-dependent kinase 4

Mengjie Yang, Xuecen Wang, Zhihua Ye, Tingyu Liu, Yuan Meng, Youfa Duan, Xuexia Yuan, Xin Yue, Wenbin Deng, Ran-yi Liu

Respir Res. 2023; 24: 111. Published online 2023 Apr 15. doi: 10.1186/s12931-023-02417-2

PMCID:: PMC10105958

Abstract Article PDF–5.6M

Select item 88101992.

Cyclin-Dependent Kinase 4 is expected to be a therapeutic target for hepatocellular carcinoma metastasis using integrated bioinformatic analysis

Jia-Ning Zhang, Feng Wei, Lin-Han Lei, Yang Yang, Yuan Yang, Wei-Ping Zhou

Bioengineered. 2021; 12(2): 11728–11739. Published online 2021 Dec 12. doi: 10.1080/21655979.2021.2006942

PMCID:: PMC8810199

Abstract Article PDF–8.1M

Select item 83716253.

Basic Pan-Cancer Analysis of the Carcinogenic Effects of Cyclin-Dependent Kinase 4 (CDK4) in Human Surface Tumors

Jingping Wu, Tinghan Deng, Yuanen Huang, Hongbin Cheng

J Healthc Eng. 2021; 2021: 8493572. Published online 2021 Aug 9. doi: 10.1155/2021/8493572

PMCID:: PMC8371625

Abstract Article PDF–4.2M

Select item 76114504.

CDK4 regulates lysosomal function and mTORC1 activation to promote cancer cell survival

Laia Martínez-Carreres, Julien Puyal, Lucía C. Leal-Esteban, Meritxell Orpinell, Judit Castillo-Armengol, Albert Giralt, Oleksandr Dergai, Catherine Moret, Valentin Barquissau, Anita Nasrallah, Angélique Pabois, Lianjun Zhang, Pedro Romero, Isabel C. Lopez-Mejia, Lluis Fajas

Cancer Res. Author manuscript; available in PMC 2021 Aug 2.

Published in final edited form as: Cancer Res. 2019 Oct 15; 79(20): 5245–5259. Published online 2019 Aug 8. doi: 10.1158/0008-5472.CAN-19-0708

PMCID:: PMC7611450

Abstract Article PDF–2.8M

Select item 71769065.

Targeted Gene Expression Profile Reveals CDK4 as Therapeutic Target for Selected Patients With Adrenocortical Carcinoma

Raimunde Liang, Isabel Weigand, Juliane Lippert, Stefan Kircher, Barbara Altieri, Sonja Steinhauer, Constanze Hantel, Simone Rost, Andreas Rosenwald, Matthias Kroiss, Martin Fassnacht, Silviu Sbiera, Cristina L. Ronchi

Front Endocrinol (Lausanne) 2020; 11: 219. Published online 2020 Apr 16. doi: 10.3389/fendo.2020.00219

PMCID:: PMC7176906

Abstract Article PDF–1.1M

Select item 71003606.

No evidence for linkage with melanoma in Italian melanoma-prone families

KF Kerstann, PT Bradford, R Steighner, D Calista, MC Fargnoli, K Peris, MC Scaini, C Menin, P Ghiorzo, G Bianchi-Scarra’, AM Goldstein, MT Landi

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2020 Mar 27.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2008 Jul; 17(7): 1838–1840. doi: 10.1158/1055-9965.EPI-08-0264

PMCID:: PMC7100360

Article PDF–506K

Select item 69396697.

Inhibition of CDK4/6 by Palbociclib Significantly Extends Survival in Medulloblastoma Patient-Derived Xenograft Mouse Models

Michelle L. Cook Sangar, Laura A. Genovesi, Madison W. Nakamoto, Melissa J. Davis, Sue E. Knobluagh, Pengxiang Ji, Amanda Millar, Brandon J. Wainwright, James M. Olson

Clin Cancer Res. Author manuscript; available in PMC 2020 Jan 2.

Published in final edited form as: Clin Cancer Res. 2017 Oct 1; 23(19): 5802–5813. Published online 2017 Jun 21. doi: 10.1158/1078-0432.CCR-16-2943

PMCID:: PMC6939669

Abstract Article PDF–1.0M

Select item 59066618.

Inhibition of cyclin-dependent kinase 4 as a potential therapeutic strategy for treatment of synovial sarcoma

Xiaoyang Li, Nicole A. Seebacher, Cassandra Garbutt, Hangzhan Ma, Peng Gao, Tao Xiao, Francis J. Hornicek, Zhenfeng Duan

Cell Death Dis. 2018 May; 9(5): 446. Published online 2018 Apr 18. doi: 10.1038/s41419-018-0474-4

PMCID:: PMC5906661

Abstract Article PDF–2.1M

Select item 50851349.

Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer

Yang Shao, Yu-Qing Shen, Yan-Li Li, Chen Liang, Bing-Jie Zhang, Sheng-Di Lu, Yan-Yun He, Ping Wang, Qiang-Ling Sun, You-Xin Jin, Zhong-Liang Ma

Oncotarget. 2016 Jun 7; 7(23): 34011–34021. Published online 2016 Mar 31. doi: 10.18632/oncotarget.8514

PMCID:: PMC5085134

Abstract Article PDF–3.8M

Select item 506950110.

CDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer

Meiou Dai, Chenjing Zhang, Ayad Ali, Xinyuan Hong, Jun Tian, Chieh Lo, Nadège Fils-Aimé, Sergio A. Burgos, Suhad Ali, Jean-Jacques Lebrun

Sci Rep. 2016; 6: 35383. Published online 2016 Oct 19. doi: 10.1038/srep35383

PMCID:: PMC5069501

Abstract Article PDF–2.8M

Select item 461398811.

Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence

Sharon Brookes, Sladjana Gagrica, Elaine Sanij, Janice Rowe, Fiona J Gregory, Eiji Hara, Gordon Peters

Cell Cycle. 2015 Apr 15; 14(8): 1164–1173. Published online 2015 Feb 19. doi: 10.1080/15384101.2015.1010866

PMCID:: PMC4613988

Abstract Article PDF–627K

Select item 458334212.

CDK4 amplification reduces sensitivity to CDK4/6 inhibition in fusion-positive rhabdomyosarcoma

Mary E. Olanich, Wenyue Sun, Stephen M. Hewitt, Zied Abdullaev, Svetlana D. Pack, Frederic G. Barr

Clin Cancer Res. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Clin Cancer Res. 2015 Nov 1; 21(21): 4947–4959. Published online 2015 Mar 25. doi: 10.1158/1078-0432.CCR-14-2955

PMCID:: PMC4583342

Abstract Article PDF–2.0M

Select item 418314913.

Coordinated Expression of Cyclin-dependent Kinase-4 and its Regulators in Human Oral Tumors

MING J. POI, THOMAS J. KNOBLOCH, MARTA T. SEARS, LANA K. UHRIG, BLAKE M. WARNER, CHRISTOPHER M. WEGHORST, JUNAN LI

Anticancer Res. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Anticancer Res. 2014 Jul; 34(7): 3285–3292.

PMCID:: PMC4183149

Abstract Article PDF–488K

Select item 413320814.

CDK4 Amplification Predicts Recurrence of Well-Differentiated Liposarcoma of the Abdomen

Sanghoon Lee, Hyojun Park, Sang Yun Ha, Kwang Yeol Paik, Seung Eun Lee, Jong Man Kim, Jae Berm Park, Choon Hyuck David Kwon, Jae-Won Joh, Yoon-La Choi, Sung Joo Kim

PLoS One. 2014; 9(8): e99452. Published online 2014 Aug 14. doi: 10.1371/journal.pone.0099452

PMCID:: PMC4133208

Abstract Article PDF–569K

Select item 364686515.

CDK4 inhibition restores G₁-S arrest in MYCN-amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage

Sina Gogolin, Volker Ehemann, Gabriele Becker, Lena M. Brueckner, Daniel Dreidax, Steffen Bannert, Ingo Nolte, Larissa Savelyeva, Emma Bell, Frank Westermann

Cell Cycle. 2013 Apr 1; 12(7): 1091–1104. Published online 2013 Mar 5. doi: 10.4161/cc.24091

PMCID:: PMC3646865

Abstract Article PDF–2.8M

Select item 358744516.

Cyclin-dependent kinase 4 signaling acts as a molecular switch between syngenic differentiation and neural transdifferentiation in human mesenchymal stem cells

Janet Lee, Jeong-Hwa Baek, Kyu-Sil Choi, Hyun-Soo Kim, Hye-Young Park, Geun-Hyoung Ha, Ho Park, Kyo-Won Lee, Chang Geun Lee, Dong-Yun Yang, Hyo Eun Moon, Sun Ha Paek, Chang-Woo Lee

Cell Cycle. 2013 Feb 1; 12(3): 442–451. doi: 10.4161/cc.23308