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Select item 95701121.

A Common Variant in the CDK8 Gene Is Associated with Sporadic Pituitary Adenomas in the Portuguese Population: A Case-Control Study

Leonor M. Gaspar, Catarina I. Gonçalves, Fernando Fonseca, Davide Carvalho, Luísa Cortez, Ana Palha, Inês F. Barros, Ema Nobre, João S. Duarte, Cláudia Amaral, Maria J. Bugalho, Olinda Marques, Bernardo D. Pereira, Manuel C. Lemos

Int J Mol Sci. 2022 Oct; 23(19): 11749. Published online 2022 Oct 4. doi: 10.3390/ijms231911749

PMCID:: PMC9570112

Abstract Article PDF–289K

Select item 71508552.

Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism

Sadie Rice, Seong-man Kim, Cynthia Rodriguez, William Songock, Gaurav Raikhy, Rebecca Lopez, Lauren Henderson, Arjun Yusufji, Jason Bodily

Viruses. 2020 Mar; 12(3): 311. Published online 2020 Mar 13. doi: 10.3390/v12030311

PMCID:: PMC7150855

Abstract Article PDF–3.1M

Select item 64516953.

De Novo Missense Substitutions in the Gene Encoding CDK8, a Regulator of the Mediator Complex, Cause a Syndromic Developmental Disorder

Eduardo Calpena, Alexia Hervieu, Teresa Kaserer, Sigrid M.A. Swagemakers, Jacqueline A.C. Goos, Olajumoke Popoola, Maria Jesus Ortiz-Ruiz, Tina Barbaro-Dieber, Lucy Bownass, Eva H. Brilstra, Elise Brimble, Nicola Foulds, Theresa A. Grebe, Aster V.E. Harder, Melissa M. Lees, Kristin G. Monaghan, Ruth A. Newbury-Ecob, Kai-Ren Ong, Deborah Osio, Francis Jeshira Reynoso Santos, Maura R.Z. Ruzhnikov, Aida Telegrafi, Ellen van Binsbergen, Marieke F. van Dooren, The Deciphering Developmental Disorders Study, Peter J. van der Spek, Julian Blagg, Stephen R.F. Twigg, Irene M.J. Mathijssen, Paul A. Clarke, Andrew O.M. Wilkie

Am J Hum Genet. 2019 Apr 4; 104(4): 709–720. Published online 2019 Mar 21. doi: 10.1016/j.ajhg.2019.02.006

PMCID:: PMC6451695

Abstract Article PDF–2.0M

Select item 53550364.

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer

Martina S.J. McDermott, Alexander A. Chumanevich, Chang-uk Lim, Jiaxin Liang, Mengqian Chen, Serena Altilia, David Oliver, James M. Rae, Michael Shtutman, Hippokratis Kiaris, Balázs Győrffy, Igor B. Roninson, Eugenia V. Broude

Oncotarget. 2017 Feb 21; 8(8): 12558–12575. Published online 2017 Jan 29. doi: 10.18632/oncotarget.14894

PMCID:: PMC5355036

Abstract Article PDF–3.5M

Select item 47553065.

Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer

Eugenia V. Broude, Balázs Győrffy, Alexander A. Chumanevich, Mengqian Chen, Martina S. J. McDermott, Michael Shtutman, James F. Catroppo, Igor B. Roninson

Curr Cancer Drug Targets. Author manuscript; available in PMC 2016 Feb 16.

Published in final edited form as: Curr Cancer Drug Targets. 2015; 15(8): 739–749. doi: 10.2174/156800961508151001105814

PMCID:: PMC4755306

Abstract Article PDF–1.7M

Select item 36373576.

Tumor-suppressive effects of CDK8 in endometrial cancer cells

Weiting Gu, Chenguang Wang, Weihua Li, Fu-Ning Hsu, Lifeng Tian, Jie Zhou, Cunzhong Yuan, Xiao-Jun Xie, Tao Jiang, Sankar Addya, Yanhong Tai, Beihua Kong, Jun-Yuan Ji

Cell Cycle. 2013 Mar 15; 12(6): 987–999. Published online 2013 Mar 1. doi: 10.4161/cc.24003

PMCID:: PMC3637357

Abstract Article PDF–5.1M

Select item 30359297.

CDK8 Expression in 470 Colorectal Cancers in Relation to β-Catenin Activation, Other Molecular Alterations and Patient Survival

Ron Firestein, Kaori Shima, Katsuhiko Nosho, Natsumi Irahara, Yoshifumi Baba, Emeric Bojarski, Edward L. Giovannucci, William C. Hahn, Charles S. Fuchs, Shuji Ogino

Int J Cancer. Author manuscript; available in PMC 2011 Jun 15.

Published in final edited form as: Int J Cancer. 2010 Jun 15; 126(12): 2863–2873. doi: 10.1002/ijc.24908

PMCID:: PMC3035929

Abstract Article PDF–911K

Select item 25871388.

CDK8 is a colorectal cancer oncogene that regulates ß-catenin activity

Ron Firestein, Adam J. Bass, So Young Kim, Ian F. Dunn, Serena J. Silver, Isil Guney, Ellen Freed, Azra H. Ligon, Natalie Vena, Shuji Ogino, Milan G. Chheda, Pablo Tamayo, Stephen Finn, Yashaswi Shrestha, Jesse S. Boehm, Supriya Jain, Emeric Bojarski, Craig Mermel, Jordi Barretina, Jennifer A. Chan, Jose Baselga, Josep Tabernero, David E. Root, Charles S. Fuchs, Massimo Loda, Ramesh A. Shivdasani, Matthew Meyerson, William C. Hahn

Nature. Author manuscript; available in PMC 2009 Sep 25.

Published in final edited form as: Nature. 2008 Sep 25; 455(7212): 547–551. Published online 2008 Sep 14. doi: 10.1038/nature07179

PMCID:: PMC2587138

Abstract Article PDF–946K

Select item 104151399.

CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins

Mengqian Chen, Jing Li, Li Zhang, Lili Wang, Chen Cheng, Hao Ji, Serena Altilia, Xiaokai Ding, Guoshuai Cai, Diego Altomare, Michael Shtutman, Stephanie D Byrum, Samuel G Mackintosh, Alexey Feoktistov, Nataliya Soshnikova, Vladislav A Mogila, Victor Tatarskiy, Maksim Erokhin, Darya Chetverina, Angga Prawira, Yi Ni, Stephan Urban, Campbell McInnes, Eugenia V Broude, Igor B Roninson

Nucleic Acids Res. 2023 Aug 11; 51(14): 7288–7313. Published online 2023 Jun 28. doi: 10.1093/nar/gkad538

PMCID:: PMC10415139

Abstract Article PDF–11M

Select item 809158710.

De novo filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks

Masaki Yamamoto, Yasuko Sakamoto, Yuko Honda, Kenzo Koike, Hideaki Nakamura, Toshihiko Matsumoto, Shoji Ando

FEBS Open Bio. 2021 May; 11(5): 1299–1312. Published online 2021 Apr 3. doi: 10.1002/2211-5463.13126

PMCID:: PMC8091587

Abstract Article PDF–2.3M

Select item 756784911.

Pathogenesis of CDK8-associated disorder: two patients with novel CDK8 variants and in vitro and in vivo functional analyses of the variants

Tomoko Uehara, Kota Abe, Masayuki Oginuma, Shizuka Ishitani, Hiroshi Yoshihashi, Nobuhiko Okamoto, Toshiki Takenouchi, Kenjiro Kosaki, Tohru Ishitani

Sci Rep. 2020; 10: 17575. Published online 2020 Oct 16. doi: 10.1038/s41598-020-74642-4

PMCID:: PMC7567849

Abstract Article PDF–1.1M

Select item 745367412.

miR-592 acts as an oncogene and promotes medullary thyroid cancer tumorigenesis by targeting cyclin-dependent kinase 8

Ting Liu, Jingjing Meng, Yu Zhang

Mol Med Rep. 2020 Oct; 22(4): 3316–3326. Published online 2020 Jul 30. doi: 10.3892/mmr.2020.11392

Correction in:: Mol Med Rep. 2021 Sep; 24(3): 673.

PMCID:: PMC7453674

Abstract Article PDF–1.3M

Select item 735459913.

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection

Molly Butler, Nunya Chotiwan, Connie D. Brewster, James E. DiLisio, David F. Ackart, Brendan K. Podell, Randall J. Basaraba, Rushika Perera, Sandra L. Quackenbush, Joel Rovnak

Viruses. 2020 Jun; 12(6): 654. Published online 2020 Jun 17. doi: 10.3390/v12060654

PMCID:: PMC7354599

Abstract Article PDF–3.0M

Select item 702217614.

A precisely positioned MED12 activation helix stimulates CDK8 kinase activity

Felix Klatt, Alexander Leitner, Iana V. Kim, Hung Ho-Xuan, Elisabeth V. Schneider, Franziska Langhammer, Robin Weinmann, Melanie R. Müller, Robert Huber, Gunter Meister, Claus-D. Kuhn

Proc Natl Acad Sci U S A. 2020 Feb 11; 117(6): 2894–2905. Published online 2020 Jan 27. doi: 10.1073/pnas.1917635117

PMCID:: PMC7022176

Abstract Article PDF–1.9M

Select item 680221915.

A kinase-independent role for CDK8 in BCR-ABL1⁺ leukemia

Ingeborg Menzl, Tinghu Zhang, Angelika Berger-Becvar, Reinhard Grausenburger, Gerwin Heller, Michaela Prchal-Murphy, Leo Edlinger, Vanessa M. Knab, Iris Z. Uras, Eva Grundschober, Karin Bauer, Mareike Roth, Anna Skucha, Yao Liu, John M. Hatcher, Yanke Liang, Nicholas P. Kwiatkowski, Daniela Fux, Andrea Hoelbl-Kovacic, Stefan Kubicek, Junia V. Melo, Peter Valent, Thomas Weichhart, Florian Grebien, Johannes Zuber, Nathanael S. Gray, Veronika Sexl

Nat Commun. 2019; 10: 4741. Published online 2019 Oct 18. doi: 10.1038/s41467-019-12656-x

PMCID:: PMC6802219

Abstract Article PDF–3.2M

Select item 668811516.

HIV Transcription Is Independent of Mediator Kinases

Daniele C. Cary, Mona Rheinberger, Ajda Rojc, B. Matija Peterlin

AIDS Res Hum Retroviruses. 2019 Aug 1; 35(8): 710–717. Published online 2019 Aug 1. doi: 10.1089/aid.2019.0039

PMCID:: PMC6688115

Abstract Article PDF–314K

Select item 660256717.

Regulatory functions of the Mediator kinases CDK8 and CDK19

Charli B. Fant, Dylan J. Taatjes

Transcription. 2019; 10(2): 76–90. Published online 2018 Dec 26. doi: 10.1080/21541264.2018.1556915

PMCID:: PMC6602567

Abstract Article PDF–1.5M

Select item 561729918.

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB

Mengqian Chen, Jiaxin Liang, Hao Ji, Zhengguan Yang, Serena Altilia, Bing Hu, Adam Schronce, Martina S. J. McDermott, Gary P. Schools, Chang-uk Lim, David Oliver, Michael S. Shtutman, Tao Lu, George R. Stark, Donald C. Porter, Eugenia V. Broude, Igor B. Roninson

Proc Natl Acad Sci U S A. 2017 Sep 19; 114(38): 10208–10213. Published online 2017 Aug 30. doi: 10.1073/pnas.1710467114

PMCID:: PMC5617299

Abstract Article PDF–1.1M

Select item 467745919.

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

Trevor Dale, Paul A. Clarke, Christina Esdar, Dennis Waalboer, Olajumoke Adeniji-Popoola, Maria-Jesus Ortiz-Ruiz, Aurélie Mallinger, Rahul S. Samant, Paul Czodrowski, Djordje Musil, Daniel Schwarz, Klaus Schneider, Mark Stubbs, Ken Ewan, Elizabeth Fraser, Robert TePoele, Will Court, Gary Box, Melanie Valenti, Alexis de Haven Brandon, Sharon Gowan, Felix Rohdich, Florence Raynaud, Richard Schneider, Oliver Poeschke, Andree Blaukat, Paul Workman, Kai Schiemann, Suzanne A. Eccles, Dirk Wienke, Julian Blagg

Nat Chem Biol. Author manuscript; available in PMC 2016 May 18.

Published in final edited form as: Nat Chem Biol. 2015 Dec; 11(12): 973–980. Published online 2015 Oct 26. doi: 10.1038/nchembio.1952

PMCID:: PMC4677459

Abstract Article PDF–2.2M

Select item 464152520.

Mediator Kinase Inhibition Further Activates Super-Enhancer Associated Genes in AML

Henry E. Pelish, Brian B. Liau, Ioana I. Nitulescu, Anupong Tangpeerachaikul, Zachary C. Poss, Diogo H. Da Silva, Brittany T. Caruso, Alexander Arefolov, Olugbeminiyi Fadeyi, Amanda L. Christie, Karrie Du, Deepti Banka, Elisabeth V. Schneider, Anja Jestel, Ge Zou, Chong Si, Christopher C. Ebmeier, Roderick T. Bronson, Andrei V. Krivtsov, Andrew G. Myers, Nancy E. Kohl, Andrew L. Kung, Scott A. Armstrong, Madeleine E. Lemieux, Dylan J. Taatjes, Matthew D. Shair

Nature. Author manuscript; available in PMC 2016 Apr 8.

Published in final edited form as: Nature. 2015 Oct 8; 526(7572): 273–276. Published online 2015 Sep 28. doi: 10.1038/nature14904

PMCID:: PMC4641525

Abstract Article PDF–2.6M

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