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Select item 97016201.

Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML

Giulia Pianigiani, Andrea Gagliardi, Federica Mezzasoma, Francesca Rocchio, Valentina Tini, Barbara Bigerna, Paolo Sportoletti, Simona Caruso, Andrea Marra, Sara Peruzzi, Eleonora Petito, Giulio Spinozzi, Sharon Shacham, Yosef Landesman, Concetta Quintarelli, Paolo Gresele, Franco Locatelli, Maria Paola Martelli, Brunangelo Falini, Lorenzo Brunetti

Blood Adv. 2022 Nov 22; 6(22): 5938–5949. Published online 2022 Aug 30. doi: 10.1182/bloodadvances.2022007563

PMCID:: PMC9701620

Abstract Article PDF–2.2M

Select item 83825342.

Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain

Elisa Gorostieta-Salas, Daniel Moreno-Blas, Cristian Gerónimo-Olvera, Bulmaro Cisneros, Felipe A. Court, Susana Castro-Obregón

Oxid Med Cell Longev. 2021; 2021: 6682336. Published online 2021 Aug 13. doi: 10.1155/2021/6682336

PMCID:: PMC8382534

Abstract Article PDF–7.1M

Select item 35490833.

Structural basis for cooperativity of CRM1 export complex formation

Thomas Monecke, David Haselbach, Béla Voß, Andreas Russek, Piotr Neumann, Emma Thomson, Ed Hurt, Ulrich Zachariae, Holger Stark, Helmut Grubmüller, Achim Dickmanns, Ralf Ficner

Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3): 960–965. Published online 2012 Dec 31. doi: 10.1073/pnas.1215214110

PMCID:: PMC3549083

Abstract Article PDF–1.3M

Select item 5163894.

Enhanced Cytoplasmic Sequestration of the Nuclear Export Receptor CRM1 by NS2 Mutations Developed in the Host Regulates Parvovirus Fitness

Alberto López-Bueno, Noelia Valle, Jesús M. Gallego, Joel Pérez, José M. Almendral

J Virol. 2004 Oct; 78(19): 10674–10684. doi: 10.1128/JVI.78.19.10674-10684.2004

PMCID:: PMC516389

Abstract Article PDF–579K

Select item 86666995.

Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells

Ane Olazagoitia-Garmendia, Linda Zhang, Paula Mera, Julie K Godbout, Maialen Sebastian-DelaCruz, Iraia Garcia-Santisteban, Luis Manuel Mendoza, Alain Huerta, Iñaki Irastorza, Govind Bhagat, Peter H Green, Laura Herrero, Dolors Serra, Jose Antonio Rodriguez, Elena F Verdu, Chuan He, Jose Ramon Bilbao, Ainara Castellanos-Rubio

Gut. 2022 Jan; 71(1): 68–76. Published online 2021 Feb 1. doi: 10.1136/gutjnl-2020-322566

PMCID:: PMC8666699

Abstract Article PDF–2.1M

Select item 78097706.

Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia

Janek S. Walker, Zachary A. Hing, Bonnie Harrington, Jordan Baumhardt, Hatice Gulcin Ozer, Amy Lehman, Brian Giacopelli, Larry Beaver, Katie Williams, Jordan N. Skinner, Casey B. Cempre, Qingxiang Sun, Sharon Shacham, Benjamin R. Stromberg, Matthew K. Summers, Lynne V. Abruzzo, Laura Rassenti, Thomas J. Kipps, Sameer Parikh, Neil E. Kay, Kerry A. Rogers, Jennifer A. Woyach, Vincenzo Coppola, Yuh Min Chook, Christopher Oakes, John C. Byrd, Rosa Lapalombella

J Hematol Oncol. 2021; 14: 17. Published online 2021 Jan 15. doi: 10.1186/s13045-021-01032-2

PMCID:: PMC7809770

Abstract Article PDF–11M

Select item 72371607.

NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA

M. Mougel, C. Akkawi, C. Chamontin, J. Feuillard, L. Pessel-Vivares, M. Socol, S. Laine

RNA Biol. 2020; 17(4): 528–538. Published online 2020 Jan 23. doi: 10.1080/15476286.2020.1713539

PMCID:: PMC7237160

Abstract Article PDF–3.3M

Select item 67748348.

Altered nuclear export signal recognition as a driver of oncogenesis

Justin Taylor, Maria Sendino, Alexander N. Gorelick, Alessandro Pastore, Matthew T. Chang, Alexander V. Penson, Elena I. Gavrila, Connor Stewart, Ella M. Melnik, Florisela Herrejon Chavez, Lillian Bitner, Akihide Yoshimi, Stanley Chun-wei Lee, Daichi Inoue, Bo Liu, Xiao J. Zhang, Anthony R. Mato, Ahmet Dogan, Michael G. Kharas, Yuhong Chen, Demin Wang, Rajesh K. Soni, Ronald C. Hendrickson, Gorka Prieto, Jose A. Rodriguez, Barry S. Taylor, Omar Abdel-Wahab

Cancer Discov. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: Cancer Discov. 2019 Oct; 9(10): 1452–1467. Published online 2019 Jul 8. doi: 10.1158/2159-8290.CD-19-0298

PMCID:: PMC6774834

Abstract Article PDF–2.4M

Select item 48115039.

A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds

Marsha L. Crochiere, Erkan Baloglu, Boris Klebanov, Scott Donovan, Diego del Alamo, Margaret Lee, Michael Kauffman, Sharon Shacham, Yosef Landesman

Oncotarget. 2016 Jan 12; 7(2): 1863–1877. Published online 2015 Dec 7. doi: 10.18632/oncotarget.6495

PMCID:: PMC4811503

Abstract Article PDF–3.0M

Select item 459331410.

CRM1 Blockade by Selective Inhibitors of Nuclear Export (SINE) attenuates Kidney Cancer Growth

Hiromi Inoue, Michael Kauffman, Sharon Shacham, Yosef Landesman, Joy Yang, Christopher P. Evans, Robert H. Weiss

J Urol. Author manuscript; available in PMC 2015 Oct 5.

Published in final edited form as: J Urol. 2013 Jun; 189(6): 2317–2326. Published online 2012 Oct 16. doi: 10.1016/j.juro.2012.10.018

PMCID:: PMC4593314

Abstract Article PDF–1.1M

Select item 386883411.

AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1

Daniel G. Corum, Philip N. Tsichlis, Robin C. Muise-Helmericks

FASEB J. 2014 Jan; 28(1): 395–407. doi: 10.1096/fj.13-235382

PMCID:: PMC3868834

Abstract Article

Select item 355933212.

A CRM1-Mediated Nuclear Export Signal Is Essential for Cytoplasmic Localization of Neurogenin 3 in Neurons

Julia Simon-Areces, Estefania Acaz-Fonseca, Isabel Ruiz-Palmero, Luis-Miguel Garcia-Segura, Maria-Angeles Arevalo

PLoS One. 2013; 8(1): e55237. Published online 2013 Jan 30. doi: 10.1371/journal.pone.0055237

PMCID:: PMC3559332

Abstract Article PDF–842K

Select item 287764613.

The Mobile FG Nucleoporin Nup98 Is a Cofactor for Crm1-dependent Protein Export

Masahiro Oka, Munehiro Asally, Yoshinari Yasuda, Yutaka Ogawa, Taro Tachibana, Yoshihiro Yoneda

Mol Biol Cell. 2010 Jun 1; 21(11): 1885–1896. doi: 10.1091/mbc.E09-12-1041

PMCID:: PMC2877646

Abstract Article PDF–2.2M

Select item 10430414.

Nuclear Export Factor CRM1 Interacts with Nonstructural Proteins NS2 from Parvovirus Minute Virus of Mice

Ursula Bodendorf, Celina Cziepluch, Jean-Claude Jauniaux, Jean Rommelaere, Nathalie Salomé

J Virol. 1999 Sep; 73(9): 7769–7779. doi: 10.1128/jvi.73.9.7769-7779.1999

PMCID:: PMC104304

Abstract Article PDF–1.6M

Select item 591448415.

Differential interaction between human and murine Crm1 and lentiviral Rev proteins

Yan Yue, Ayse K. Coskun, Navneet Jawanda, Jim Auer, Richard E. Sutton

Virology. Author manuscript; available in PMC 2018 Apr 24.

Published in final edited form as: Virology. 2018 Jan 1; 513: 1–10. Published online 2017 Oct 10. doi: 10.1016/j.virol.2017.09.027

PMCID:: PMC5914484

Abstract Article PDF–1.5M

Select item 491174016.

Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-κB Signaling Pathway

Shoko Saito, Sadik Cigdem, Mitsuru Okuwaki, Kyosuke Nagata

Mol Cell Biol. 2016 Jul 1; 36(13): 1820–1835. Prepublished online 2016 Apr 25. Published online 2016 Jun 15. doi: 10.1128/MCB.00158-16

PMCID:: PMC4911740

Abstract Article PDF–7.9M

Select item 339566317.

Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTα by accessing a nuclear export signal

Marianna Agassandian, Bill B. Chen, Roopa Pulijala, Leah Kaercher, Jennifer R. Glasser, Rama K. Mallampalli

Mol Biol Cell. 2012 Jul 15; 23(14): 2755–2769. doi: 10.1091/mbc.E11-10-0863

PMCID:: PMC3395663

Abstract Article PDF–2.7M

Select item 291082418.

POLY(ADP-RIBOSE) POLYMERASE-1 IS A DETERMINING FACTOR IN CRM1-MEDIATED NUCLEAR EXPORT AND RETENTION OF P65 NF-κB UPON TLR4 STIMULATION

Mourad Zerfaoui, Youssef Errami, Amarjit S. Naura, Yasuhiro Suzuki, Hogyoung Kim, Jihang Ju, Tao Liu, Chetan P. Hans, Jong G. Kim, Zakaria Y. Abd Elmageed, Shahriar Koochekpour, Andrew Catling, A. Hamid Boulares

J Immunol. Author manuscript; available in PMC 2011 Aug 1.

Published in final edited form as: J Immunol. 2010 Aug 1; 185(3): 1894–1902. Published online 2010 Jul 7. doi: 10.4049/jimmunol.1000646

PMCID:: PMC2910824

Abstract Article PDF–2.8M

Select item 2264919.

Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

Salme Taagepera, David McDonald, Jonathan E. Loeb, Laura L. Whitaker, Anita K. McElroy, Jean Y. J. Wang, Thomas J. Hope

Proc Natl Acad Sci U S A. 1998 Jun 23; 95(13): 7457–7462. doi: 10.1073/pnas.95.13.7457

PMCID:: PMC22649

Abstract Article PDF–674K

Select item 616581920.

Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial

Weiguo Zhang, Charlie Ly, Jo Ishizawa, Hong Mu, Vivian Ruvolo, Sharon Shacham, Naval Daver, Michael Andreeff

Haematologica. 2018 Oct; 103(10): 1642–1653. Prepublished online 2018 May 17. doi: 10.3324/haematol.2017.185082

PMCID:: PMC6165819

Abstract Article PDF–3.1M

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