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Items: 1 to 20 of 66

1.
ACLY alternative splicing correlates with cancer phenotypes
Julianna G. Supplee, Hayley C. Affronti, Richard Duan, Rebekah C. Brooks, Zachary E. Stine, Phuong T.T. Nguyen, Laura V. Pinheiro, Michael C. Noji, Jack M. Drummond, Kevin Huang, Kollin Schultz, Chi V. Dang, Ronen Marmorstein, Kathryn E. Wellen
J Biol Chem. 2024 Jul; 300(7): 107418. Published online 2024 May 28. doi: 10.1016/j.jbc.2024.107418
PMCID:
PMC11260853
AbstractArticlePDF–4.1M
2.
Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
Sully Fernandez, John M. Viola, AnnMarie Torres, Martina Wallace, Sophie Trefely, Steven Zhao, Hayley C. Affronti, Jivani M. Gengatharan, David A. Guertin, Nathaniel W. Snyder, Christian M. Metallo, Kathryn E. Wellen
Cell Rep. Author manuscript; available in PMC 2019 Jul 3.
Published in final edited form as: Cell Rep. 2019 May 28; 27(9): 2772–2784.e6. doi: 10.1016/j.celrep.2019.04.112
PMCID:
PMC6608748
AbstractArticlePDF–2.2M
3.
ATP-citrate lyase controls a glucose-to-acetate metabolic switch
Steven Zhao, AnnMarie Torres, Ryan A. Henry, Sophie Trefely, Martina Wallace, Joyce V. Lee, Alessandro Carrer, Arjun Sengupta, Sydney L. Campbell, Yin-Ming Kuo, Alexander J. Frey, Noah Meurs, John M. Viola, Ian A. Blair, Aalim M. Weljie, Christian M. Metallo, Nathaniel W. Snyder, Andrew J. Andrews, Kathryn E. Wellen
Cell Rep. Author manuscript; available in PMC 2016 Dec 21.
Published in final edited form as: Cell Rep. 2016 Oct 18; 17(4): 1037–1052. doi: 10.1016/j.celrep.2016.09.069
PMCID:
PMC5175409
AbstractArticlePDF–2.1M
4.
Glucose-dependent de Novo Lipogenesis in B Lymphocytes: A REQUIREMENT FOR ATP-CITRATE LYASE IN LIPOPOLYSACCHARIDE-INDUCED DIFFERENTIATION
Fay J. Dufort, Maria R. Gumina, Nathan L. Ta, Yongzhen Tao, Shannon A. Heyse, David A. Scott, Adam D. Richardson, Thomas N. Seyfried, Thomas C. Chiles
J Biol Chem. 2014 Mar 7; 289(10): 7011–7024. Published online 2014 Jan 27. doi: 10.1074/jbc.M114.551051
PMCID:
PMC3945362
AbstractArticlePDF–1.7M
5.
Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice
Qiong Wang, Shoufeng Li, Lei Jiang, Yunhua Zhou, Zi Li, Mengle Shao, Wenjun Li, Yong Liu
J Lipid Res. 2010 Sep; 51(9): 2516–2526. doi: 10.1194/jlr.M003335
PMCID:
PMC2918436
AbstractArticlePDF–1.3M
6.
Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice
Batuhan Yenilmez, Mark Kelly, Guo-Fang Zhang, Nicole Wetoska, Olga R. Ilkayeva, Kyounghee Min, Leslie Rowland, Chloe DiMarzio, Wentao He, Naideline Raymond, Lawrence Lifshitz, Meixia Pan, Xianlin Han, Jun Xie, Randall H. Friedline, Jason K. Kim, Guangping Gao, Mark A. Herman, Christopher B. Newgard, Michael P. Czech
J Biol Chem. 2022 Oct; 298(10): 102401. Published online 2022 Aug 18. doi: 10.1016/j.jbc.2022.102401
PMCID:
PMC9490592
AbstractArticlePDF–1.6M
7.
Lactate supports a metabolic-epigenetic link in macrophage polarization
Jordan T. Noe, Beatriz E. Rendon, Anne E. Geller, Lindsey R. Conroy, Samantha M. Morrissey, Lyndsay E.A. Young, Ronald C. Bruntz, Eun J. Kim, Ashley Wise-Mitchell, Mariana Barbosa de Souza Rizzo, Eric R. Relich, Becca V. Baby, Lance A. Johnson, Hayley C. Affronti, Kelly M. McMasters, Brian F. Clem, Matthew S. Gentry, Jun Yan, Kathryn E. Wellen, Ramon C. Sun, Robert A. Mitchell
Sci Adv. 2021 Nov; 7(46): eabi8602. Published online 2021 Nov 12. doi: 10.1126/sciadv.abi8602
PMCID:
PMC8589316
AbstractArticlePDF–2.6M
8.
Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes
Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche
Front Immunol. 2021; 12: 669920. Published online 2021 Apr 26. doi: 10.3389/fimmu.2021.669920
PMCID:
PMC8107722
AbstractArticlePDF–7.9M
9.
FABP7 Regulates Acetyl-CoA Metabolism Through the Interaction with ACLY in the Nucleus of Astrocytes
Yoshiteru Kagawa, Banlanjo Abdulaziz Umaru, Hiroki Shima, Ryo Ito, Ryo Zama, Ariful Islam, Shin-ichiro Kanno, Akira Yasui, Shun Sato, Kosuke Jozaki, Subrata Kumar Shil, Hirofumi Miyazaki, Shuhei Kobayashi, Yui Yamamoto, Hiroshi Kogo, Chie Shimamoto-Mitsuyama, Akira Sugawara, Norihiro Sugino, Masayuki Kanamori, Teiji Tominaga, Takeo Yoshikawa, Kohji Fukunaga, Kazuhiko Igarashi, Yuji Owada
Mol Neurobiol. 2020; 57(12): 4891–4910. Published online 2020 Aug 19. doi: 10.1007/s12035-020-02057-3
PMCID:
PMC7541391
AbstractArticlePDF–2.4M
10.
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate
Steven Zhao, Cholsoon Jang, Joyce Liu, Kahealani Uehara, Michael Gilbert, Luke Izzo, Xianfeng Zeng, Sophie Trefely, Sully Fernandez, Alessandro Carrer, Katelyn D. Miller, Zachary T. Schug, Nathaniel W. Snyder, Terence P. Gade, Paul M. Titchenell, Joshua D. Rabinowitz, Kathryn E. Wellen
Nature. Author manuscript; available in PMC 2020 Sep 18.
Published in final edited form as: Nature. 2020 Mar; 579(7800): 586–591. Published online 2020 Mar 18. doi: 10.1038/s41586-020-2101-7
PMCID:
PMC7416516
AbstractArticlePDF–6.1M
11.
Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease
Liang Guo, Ying-Ying Guo, Bai-Yu Li, Wan-Qiu Peng, Xin-Xia Chang, Xin Gao, Qi-Qun Tang
J Biol Chem. 2019 Aug 2; 294(31): 11805–11816. Published online 2019 Jun 13. doi: 10.1074/jbc.RA119.008708
PMCID:
PMC6682731
AbstractArticlePDF–2.5M
12.
ATP-Citrate Lyase Reduction Mediates Palmitate-induced Apoptosis in Pancreatic Beta Cells
Kwan Yi Chu, Yalin Lin, Alon Hendel, Jerzy E. Kulpa, Roger W. Brownsey, James D. Johnson
J Biol Chem. 2010 Oct 15; 285(42): 32606–32615. Published online 2010 Aug 7. doi: 10.1074/jbc.M110.157172
PMCID:
PMC2952263
AbstractArticlePDF–2.4M
13.
ATP-citrate lyase links cellular metabolism to histone acetylation
Kathryn E. Wellen, Georgia Hatzivassiliou, Uma M. Sachdeva, Thi V. Bui, Justin R. Cross, Craig B. Thompson
Science. Author manuscript; available in PMC 2009 Sep 18.
Published in final edited form as: Science. 2009 May 22; 324(5930): 1076–1080. doi: 10.1126/science.1164097
PMCID:
PMC2746744
AbstractArticlePDF–1.1M
14.
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway
Nianyin Lv, Sufeng Jin, Zihao Liang, Xiaohui Wu, Yanhua Kang, Lan Su, Yeping Dong, Bingwei Wang, Tonghui Ma, Liyun Shi
Front Immunol. 2021; 12: 751409. Published online 2022 Jan 7. doi: 10.3389/fimmu.2021.751409
PMCID:
PMC8777276
AbstractArticlePDF–10M
15.
Acetyl-CoA metabolism supports multi-step pancreatic tumorigenesis
Alessandro Carrer, Sophie Trefely, Steven Zhao, Sydney L. Campbell, Robert J. Norgard, Kollin C. Schulz, Simone Sidoli, Joshua L. D. Parris, Hayley C. Affronti, Sharanya Sivanand, Shaun Egolf, Yogev Sela, Marco Trizzino, Alessandro Gardini, Benjamin A. Garcia, Nathaniel W. Snyder, Ben Z. Stanger, Kathryn E. Wellen
Cancer Discov. Author manuscript; available in PMC 2020 Mar 1.
Published in final edited form as: Cancer Discov. 2019 Mar; 9(3): 416–435. Published online 2019 Jan 9. doi: 10.1158/2159-8290.CD-18-0567
PMCID:
PMC6643997
AbstractArticlePDF–3.1M
16.
Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart
Anja Karlstaedt, Xiaotian Zhang, Heidi Vitrac, Romain Harmancey, Hernan Vasquez, Jing Han Wang, Margaret A. Goodell, Heinrich Taegtmeyer
Proc Natl Acad Sci U S A. 2016 Sep 13; 113(37): 10436–10441. Published online 2016 Aug 31. doi: 10.1073/pnas.1601650113
PMCID:
PMC5027422
AbstractArticlePDF–941K
17.
DNMT1 Is Regulated by ATP-Citrate Lyase and Maintains Methylation Patterns during Adipocyte Differentiation
Tatiana Londoño Gentile, Chao Lu, Peter M. Lodato, Sarah Tse, Scott H. Olejniczak, Eric S. Witze, Craig B. Thompson, Kathryn E. Wellen
Mol Cell Biol. 2013 Oct; 33(19): 3864–3878. doi: 10.1128/MCB.01495-12
PMCID:
PMC3811875
AbstractArticlePDF–3.4M
18.
Differences between Human and Rodent Pancreatic Islets: LOW PYRUVATE CARBOXYLASE, ATP CITRATE LYASE, AND PYRUVATE CARBOXYLATION AND HIGH GLUCOSE-STIMULATED ACETOACETATE IN HUMAN PANCREATIC ISLETS
Michael J. MacDonald, Melissa J. Longacre, Scott W. Stoker, Mindy Kendrick, Ansaya Thonpho, Laura J. Brown, Noaman M. Hasan, Sarawut Jitrapakdee, Toshiyuki Fukao, Matthew S. Hanson, Luis A. Fernandez, Jon Odorico
J Biol Chem. 2011 May 27; 286(21): 18383–18396. Published online 2011 Mar 22. doi: 10.1074/jbc.M111.241182
PMCID:
PMC3099655
AbstractArticlePDF–1009K
19.
Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance
Fabiola Diniz, Nguyen Yen Nhi Ngo, Mariel Colon-Leyva, Francesca Edgington-Giordano, Sylvia Hilliard, Kevin Zwezdaryk, Jiao Liu, Samir S. El-Dahr, Giovane G. Tortelote
Nat Commun. 2023; 14: 7733. Published online 2023 Nov 25. doi: 10.1038/s41467-023-43513-7
PMCID:
PMC10676360
AbstractArticlePDF–12M
20.
Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress
Wenjun Wang, Junyang Tan, Xiaomin Liu, Wenqi Guo, Mengmeng Li, Xinjie Liu, Yanyan Liu, Wenyu Dai, Liubing Hu, Yimin Wang, Qiuxia Lu, Wen Xing Lee, Hong-Wen Tang, Qinghua Zhou
Nat Commun. 2023; 14: 6201. Published online 2023 Oct 4. doi: 10.1038/s41467-023-41757-x
Correction in:
Nat Commun. 2024; 15: 7167.
PMCID:
PMC10550995
AbstractArticlePDF–3.0M

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