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Select item 90516611.

The role of splicing factor PRPF8 in breast cancer

Difei Cao, Jiaying Xue, Guoqing Huang, Jing An, Weiwei An

Technol Health Care. 2022; 30(Suppl 1): 293–301. Prepublished online 2022 Jan 21. Published online 2022 Feb 25. doi: 10.3233/THC-THC228028

PMCID:: PMC9051661

Abstract Article PDF–2.2M

Select item 58849032.

Variants in the PRPF8 Gene are Associated with Glaucoma

Shazia Micheal, Barend F. Hogewind, Muhammad Imran Khan, Sorath Noorani Siddiqui, Saemah Nuzhat Zafar, Farah Akhtar, Raheel Qamar, Carel B. Hoyng, Anneke I. den Hollander

Mol Neurobiol. 2018; 55(5): 4504–4510. Published online 2017 Jul 13. doi: 10.1007/s12035-017-0673-5

PMCID:: PMC5884903

Abstract Article PDF–2.7M

Select item 46044373.

Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5′ splice site

Carsten Boesler, Norbert Rigo, Dmitry E. Agafonov, Berthold Kastner, Henning Urlaub, Cindy L. Will, Reinhard Lührmann

RNA. 2015 Nov; 21(11): 1993–2005. doi: 10.1261/rna.053991.115

PMCID:: PMC4604437

Abstract Article PDF–1.2M

Select item 45788454.

Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5′ splice site strength

Vihandha O. Wickramasinghe, Mar Gonzàlez-Porta, David Perera, Arthur R. Bartolozzi, Christopher R. Sibley, Martina Hallegger, Jernej Ule, John C. Marioni, Ashok R. Venkitaraman

Genome Biol. 2015; 16(1): 201. Published online 2015 Sep 21. doi: 10.1186/s13059-015-0749-3

PMCID:: PMC4578845

Abstract Article PDF–3.9M

Select item 40847995.

A mutation in a splicing factor that causes retinitis pigmentosa has a transcriptome-wide effect on mRNA splicing

Paul K Korir, Lisa Roberts, Raj Ramesar, Cathal Seoighe

BMC Res Notes. 2014; 7: 401. Published online 2014 Jun 27. doi: 10.1186/1756-0500-7-401

PMCID:: PMC4084799

Abstract Article PDF–393K

Select item 40727786.

Cytoplasmic Viral RNA-Dependent RNA Polymerase Disrupts the Intracellular Splicing Machinery by Entering the Nucleus and Interfering with Prp8

Yen-Chin Liu, Rei-Lin Kuo, Jing-Yi Lin, Peng-Nien Huang, Yi Huang, Hsuan Liu, Jamine J. Arnold, Shu-Jen Chen, Robert Yung-Liang Wang, Craig E. Cameron, Shin-Ru Shih

PLoS Pathog. 2014 Jun; 10(6): e1004199. Published online 2014 Jun 26. doi: 10.1371/journal.ppat.1004199

PMCID:: PMC4072778

Abstract Article PDF–5.9M

Select item 19145537.

Map refinement of locus RP13 to human chromosome 17p13.3 in a second family with autosomal dominant retinitis pigmentosa.

T. L. Kojis, C. Heinzmann, P. Flodman, J. T. Ngo, R. S. Sparkes, M. A. Spence, J. B. Bateman, J. R. Heckenlively

Am J Hum Genet. 1996 Feb; 58(2): 347–355.

PMCID:: PMC1914553

Summary Page Browse PDF–1.2M

Select item 18015258.

Fine localization of the locus for autosomal dominant retinitis pigmentosa on chromosome 17p.

R Goliath, Y Shugart, P Janssens, J Weissenbach, P Beighton, R Ramasar, J Greenberg

Am J Hum Genet. 1995 Oct; 57(4): 962–964.

PMCID:: PMC1801525

Summary Page Browse PDF–675K

Select item 13707429.

Prp8 protein: At the heart of the spliceosome

RICHARD J. GRAINGER, JEAN D. BEGGS

RNA. 2005 May; 11(5): 533–557. doi: 10.1261/rna.2220705

PMCID:: PMC1370742

Abstract Article PDF–1.5M

Select item 136981410.

The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes.

H R Luo, G A Moreau, N Levin, M J Moore

RNA. 1999 Jul; 5(7): 893–908. doi: 10.1017/s1355838299990520

PMCID:: PMC1369814

Summary PDF–1.7M

Select item 136974911.

The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site.

J L Reyes, E H Gustafson, H R Luo, M J Moore, M M Konarska

RNA. 1999 Feb; 5(2): 167–179. doi: 10.1017/s1355838299981785

PMCID:: PMC1369749

Summary PDF–592K

Select item 136936412.

The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome.

J L Reyes, P Kois, B B Konforti, M M Konarska

RNA. 1996 Mar; 2(3): 213–225.

PMCID:: PMC1369364

Summary PDF–5.1M

Select item 117010113.

Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals.

M D Chiara, L Palandjian, R Feld Kramer, R Reed

EMBO J. 1997 Aug 1; 16(15): 4746–4759. doi: 10.1093/emboj/16.15.4746

PMCID:: PMC1170101

Summary PDF–799K

Select item 5383814.

A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein.

M A Garcia-Blanco, G J Anderson, J Beggs, P A Sharp

Proc Natl Acad Sci U S A. 1990 Apr; 87(8): 3082–3086. doi: 10.1073/pnas.87.8.3082

PMCID:: PMC53838

Summary Page Browse PDF–1.2M

Select item 1100931315.

PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5´-splice-site selection causing tissue-specific defects

Robert Atkinson, Maria Georgiou, Chunbo Yang, Katarzyna Szymanska, Albert Lahat, Elton J. R. Vasconcelos, Yanlong Ji, Marina Moya Molina, Joseph Collin, Rachel Queen, Birthe Dorgau, Avril Watson, Marzena Kurzawa-Akanbi, Ross Laws, Abhijit Saxena, Chia Shyan Beh, Chileleko Siachisumo, Franziska Goertler, Magdalena Karwatka, Tracey Davey, Chris F. Inglehearn, Martin McKibbin, Reinhard Lührmann, David H. Steel, David J. Elliott, Lyle Armstrong, Henning Urlaub, Robin R. Ali, Sushma-Nagaraja Grellscheid, Colin A. Johnson, Sina Mozaffari-Jovin, Majlinda Lako

Nat Commun. 2024; 15: 3138. Published online 2024 Apr 11. doi: 10.1038/s41467-024-47253-0

PMCID:: PMC11009313

Abstract Article PDF–11M

Select item 989856816.

PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing

Juan L. López-Cánovas, Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Antonio C. Fuentes-Fayos, Araceli Lara-López, Marina E. Sánchez-Frias, Víctor Amado, Rubén Ciria, Javier Briceño, Manuel de la Mata, Justo P. Castaño, Manuel Rodriguez-Perálvarez, Raúl M. Luque, Manuel D. Gahete

Exp Mol Med. 2023 Jan; 55(1): 132–142. Published online 2023 Jan 6. doi: 10.1038/s12276-022-00917-7

PMCID:: PMC9898568

Abstract Article PDF–6.0M

Select item 962949017.

Structural and functional investigation of the human snRNP assembly factor AAR2 in complex with the RNase H-like domain of PRPF8

Marco Preussner, Karine F. Santos, Jonathan Alles, Christina Heroven, Florian Heyd, Markus C. Wahl, Gert Weber

Acta Crystallogr D Struct Biol. 2022 Nov 1; 78(Pt 11): 1373–1383. Published online 2022 Oct 27. doi: 10.1107/S2059798322009755

PMCID:: PMC9629490

Abstract Article PDF–1.8M

Select item 702911418.

The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit

Karen Vester, Karine F. Santos, Benno Kuropka, Christoph Weise, Markus C. Wahl

J Biol Chem. 2020 Feb 14; 295(7): 2097–2112. Published online 2019 Dec 30. doi: 10.1074/jbc.RA119.010964

PMCID:: PMC7029114

Abstract Article PDF–5.3M

Select item 627464719.

Structures of the human pre-catalytic spliceosome and its precursor spliceosome

Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei, Yigong Shi

Cell Res. 2018 Dec; 28(12): 1129–1140. Published online 2018 Oct 12. doi: 10.1038/s41422-018-0094-7

PMCID:: PMC6274647

Abstract Article PDF–12M

Select item 260347220.

Evaluation of splicing efficiency in lymphoblastoid cell lines from patients with splicing-factor retinitis pigmentosa

Lenka Ivings, Katherine V. Towns, M.A. Matin, Charles Taylor, Frederique Ponchel, Richard J. Grainger, Rajkumar S. Ramesar, David A. Mackey, Chris F. Inglehearn

Mol Vis. 2008; 14: 2357–2366. Published online 2008 Dec 18.

PMCID:: PMC2603472

Abstract Article PDF–3.5M

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