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Select item 67857861.

⁶⁸Ga-DOTA-E[c(RGDfK)]₂ PET Imaging of SHARPIN-Regulated Integrin Activity in Mice

Riikka Siitonen, Emilia Peuhu, Anu Autio, Heidi Liljenbäck, Elina Mattila, Olli Metsälä, Meeri Käkelä, Tiina Saanijoki, Ingrid Dijkgraaf, Sirpa Jalkanen, Johanna Ivaska, Anne Roivainen

J Nucl Med. 2019 Oct; 60(10): 1380–1387. doi: 10.2967/jnumed.118.222026

PMCID:: PMC6785786

Abstract Article PDF–1.1M

Select item 59196192.

Profiling of epidermal lipids in a mouse model of dermatitis: Identification of potential biomarkers

Jackeline Franco, Christina Ferreira, Tiago J. Paschoal Sobreira, John P. Sundberg, Harm HogenEsch

PLoS One. 2018; 13(4): e0196595. Published online 2018 Apr 26. doi: 10.1371/journal.pone.0196595

PMCID:: PMC5919619

Abstract Article PDF–4.0M

Select item 51649543.

Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis

Harm HogenEsch, Mario Sola, Timothy M. Stearns, Kathleen A. Silva, Victoria E. Kennedy, John P. Sundberg

Exp Mol Pathol. Author manuscript; available in PMC 2017 Dec 1.

Published in final edited form as: Exp Mol Pathol. 2016 Dec; 101(3): 303–307. Published online 2016 Oct 26. doi: 10.1016/j.yexmp.2016.05.015

PMCID:: PMC5164954

Abstract Article PDF–1.1M

Select item 35704094.

Loss of Function of the Mouse Sharpin Gene Results in Peyer’s Patch Regression

Rosemarie Seymour, Bobbi-Jo Shirley, Harm HogenEsch, Leonard D. Shultz, John P. Sundberg

PLoS One. 2013; 8(2): e55224. Published online 2013 Feb 12. doi: 10.1371/journal.pone.0055224

PMCID:: PMC3570409

Abstract Article PDF–2.3M

Select item 32794185.

SHARPIN Is Essential for Cytokine Production, NF-κB Signaling, and Induction of Th1 Differentiation by Dendritic Cells

Zhe Wang, Anna Sokolovska, Rosemarie Seymour, John P. Sundberg, Harm HogenEsch

PLoS One. 2012; 7(2): e31809. Published online 2012 Feb 14. doi: 10.1371/journal.pone.0031809

PMCID:: PMC3279418

Abstract Article PDF–1.1M

Select item 31526476.

SHARPIN regulates mitochondria-dependent apoptosis in keratinocytes

Yanhua Liang, John P Sundberg

J Dermatol Sci. Author manuscript; available in PMC 2012 Sep 1.

Published in final edited form as: J Dermatol Sci. 2011 Sep; 63(3): 148–153. Published online 2011 May 7. doi: 10.1016/j.jdermsci.2011.04.012

PMCID:: PMC3152647

Abstract Article PDF–3.5M

Select item 18871927.

A spontaneous mutation characterized by chronic proliferative dermatitis in C57BL mice.

H. HogenEsch, M. J. Gijbels, E. Offerman, J. van Hooft, D. W. van Bekkum, C. Zurcher

Am J Pathol. 1993 Sep; 143(3): 972–982.

PMCID:: PMC1887192

Summary Page Browse PDF–2.8M

Select item 18617068.

Pathogenesis of skin lesions in mice with chronic proliferative dermatitis (cpdm/cpdm).

M. J. Gijbels, C. Zurcher, G. Kraal, G. R. Elliott, H. HogenEsch, G. Schijff, H. F. Savelkoul, P. L. Bruijnzeel

Am J Pathol. 1996 Mar; 148(3): 941–950.

PMCID:: PMC1861706

Summary Page Browse PDF–2.3M

Select item 67007879.

Sharpin suppresses β1-integrin activation by complexing with the β1 tail and kindlin-1

Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu, Yan-Qing Ma

Cell Commun Signal. 2019; 17: 101. Published online 2019 Aug 20. doi: 10.1186/s12964-019-0407-6

PMCID:: PMC6700787

Abstract Article PDF–2.2M

Select item 646038310.

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice

Bhesh Raj Sharma, Rajendra Karki, Ein Lee, Qifan Zhu, Prajwal Gurung, Thirumala-Devi Kanneganti

Cell Death Differ. 2019 Apr; 26(4): 741–750. Published online 2018 Jul 23. doi: 10.1038/s41418-018-0159-7

PMCID:: PMC6460383

Abstract Article PDF–3.0M

Select item 523999711.

SHARPIN regulates collagen architecture and ductal outgrowth in the developing mouse mammary gland

Emilia Peuhu, Riina Kaukonen, Martina Lerche, Markku Saari, Camilo Guzmán, Pia Rantakari, Nicola De Franceschi, Anni Wärri, Maria Georgiadou, Guillaume Jacquemet, Elina Mattila, Reetta Virtakoivu, Yuming Liu, Youmna Attieh, Kathleen A Silva, Timo Betz, John P Sundberg, Marko Salmi, Marie‐Ange Deugnier, Kevin W Eliceiri, Johanna Ivaska

EMBO J. 2017 Jan 17; 36(2): 165–182. Published online 2016 Dec 14. doi: 10.15252/embj.201694387

PMCID:: PMC5239997

Abstract Article PDF–1.9M

Select item 491911412.

SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex

Yoon Park, Hyung-seung Jin, Justine Lopez, Jeeho Lee, Lujian Liao, Chris Elly, Yun-Cai Liu

Nat Immunol. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Nat Immunol. 2016 Mar; 17(3): 286–296. Published online 2016 Feb 1. doi: 10.1038/ni.3352

PMCID:: PMC4919114

Abstract Article PDF–3.6M

Select item 467970013.

The pathogenesis of chronic eosinophilic esophagitis in SHARPIN-deficient mice

Syu-Jhe Chien, Kathleen A. Silva, Victoria E. Kennedy, Harm HogenEsch, John P. Sundberg

Exp Mol Pathol. Author manuscript; available in PMC 2016 Dec 1.

Published in final edited form as: Exp Mol Pathol. 2015 Dec; 99(3): 460–467. Published online 2015 Aug 29. doi: 10.1016/j.yexmp.2015.08.012

PMCID:: PMC4679700

Abstract Article PDF–812K

Select item 434074914.

SHANK-associated RH domain interacting protein (SHARPIN) is required for optimal NLRP3 inflammasome activation

Prajwal Gurung, Mohamed Lamkanfi, Thirumala-Devi Kanneganti

J Immunol. Author manuscript; available in PMC 2016 Mar 1.

Published in final edited form as: J Immunol. 2015 Mar 1; 194(5): 2064–2067. Published online 2015 Jan 30. doi: 10.4049/jimmunol.1402951

PMCID:: PMC4340749

Abstract Article PDF–760K

Select item 427009915.

TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice

James A Rickard, Holly Anderton, Nima Etemadi, Ueli Nachbur, Maurice Darding, Nieves Peltzer, Najoua Lalaoui, Kate E Lawlor, Hannah Vanyai, Cathrine Hall, Aleks Bankovacki, Lahiru Gangoda, Wendy Wei-Lynn Wong, Jason Corbin, Chunzi Huang, Edward S Mocarski, James M Murphy, Warren S Alexander, Anne K Voss, David L Vaux, William J Kaiser, Henning Walczak, John Silke

eLife. 2014; 3: e03464. Published online 2014 Dec 2. doi: 10.7554/eLife.03464

PMCID:: PMC4270099

Abstract Article PDF–6.5M

Select item 404876316.

RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice

Scott B. Berger, Viera Kasparcova, Sandy Hoffman, Barb Swift, Lauren Dare, Michelle Schaeffer, Carol Capriotti, Michael Cook, Joshua Finger, Angela Hughes-Earle, Philip A. Harris, William J. Kaiser, Edward S. Mocarski, John Bertin, Peter J. Gough

J Immunol. Author manuscript; available in PMC 2015 Jun 15.

Published in final edited form as: J Immunol. 2014 Jun 15; 192(12): 5476–5480. Published online 2014 May 12. doi: 10.4049/jimmunol.1400499

PMCID:: PMC4048763

Abstract Article PDF–611K

Select item 285246817.

Anti-IL5 decreases the number of eosinophils but not the severity of dermatitis in SHARPIN-deficient mice

Matthew L. Renninger, Rosemarie E. Seymour, Laurence O. Whiteley, John P. Sundberg, Harm HogenEsch

Exp Dermatol. Author manuscript; available in PMC 2011 Mar 1.

Published in final edited form as: Exp Dermatol. 2010 Mar; 19(3): 252–258. Published online 2009 Jul 23. doi: 10.1111/j.1600-0625.2009.00944.x

PMCID:: PMC2852468

Abstract Article PDF–290K

Select item 737117818.

Keratinocyte-specific deletion of SHARPIN induces atopic dermatitis-like inflammation in mice

John P. Sundberg, C. Herbert Pratt, Leslie P. Goodwin, Kathleen A. Silva, Victoria E. Kennedy, Christopher S. Potter, Anisa Dunham, Beth A. Sundberg, Harm HogenEsch

PLoS One. 2020; 15(7): e0235295. Published online 2020 Jul 20. doi: 10.1371/journal.pone.0235295

PMCID:: PMC7371178

Abstract Article PDF–3.5M

Select item 714208119.

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation

Lucie Laurien, Masahiro Nagata, Hannah Schünke, Tom Delanghe, Janica L. Wiederstein, Snehlata Kumari, Robin Schwarzer, Teresa Corona, Marcus Krüger, Mathieu J. M. Bertrand, Vangelis Kondylis, Manolis Pasparakis

Nat Commun. 2020; 11: 1747. Published online 2020 Apr 8. doi: 10.1038/s41467-020-15466-8

PMCID:: PMC7142081

Abstract Article PDF–3.7M

Select item 633679620.

LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores

Min Wu, Yan Chang, Huaibin Hu, Rui Mu, Yucheng Zhang, Xuanhe Qin, Xiaotao Duan, Weihua Li, Haiqing Tu, Weina Zhang, Guang Wang, Qiuying Han, Ailing Li, Tao Zhou, Kazuhiro Iwai, Xuemin Zhang, Huiyan Li

Nat Commun. 2019; 10: 273. Published online 2019 Jan 17. doi: 10.1038/s41467-018-08043-7

PMCID:: PMC6336796

Abstract Article PDF–4.9M

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