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Select item 110956321.

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability

Florence Authier, Nina Ondruskova, Andrew T. Ferenbach, Alison D. McNeilly, Daan M. F. van Aalten

Dis Model Mech. 2024 Apr 1; 17(4): dmm050671. Published online 2024 Apr 25. doi: 10.1242/dmm.050671

PMCID:: PMC11095632

Abstract Article

Select item 109817002.

Paternal DDT exposure induces sex-specific programming of fetal growth, placenta development and offspring’s health phenotypes in a mouse model

Elaine Chen, Raquel Santana da Cruz, Aallya Nascimento, Meghali Joshi, Duane Gischewski Pereira, Odalys Dominguez, Gabriela Fernandes, Megan Smith, Sara P. C. Paiva, Sonia de Assis

Sci Rep. 2024; 14: 7567. Published online 2024 Mar 30. doi: 10.1038/s41598-024-58176-7

PMCID:: PMC10981700

Abstract Article PDF–3.0M

Select item 107112263.

Cardioprotective O-GlcNAc signaling is elevated in murine female hearts via enhanced O-GlcNAc transferase activity

Bhargavi Narayanan, Prithvi Sinha, Roger Henry, Russell A. Reeves, Nazareno Paolocci, Mark J. Kohr, Natasha E. Zachara

J Biol Chem. 2023 Dec; 299(12): 105447. Published online 2023 Nov 8. doi: 10.1016/j.jbc.2023.105447

PMCID:: PMC10711226

Abstract Article PDF–2.4M

Select item 102863674.

Ogt-mediated O-GlcNAcylation inhibits astrocytes activation through modulating NF-κB signaling pathway

Xiaoxue Dong, Liqi Shu, Jinyu Zhang, Xu Yang, Xuejun Cheng, Xingsen Zhao, Wenzheng Qu, Qiang Zhu, Yikai Shou, Guoping Peng, Binggui Sun, Wen Yi, Qiang Shu, Xuekun Li

J Neuroinflammation. 2023; 20: 146. Published online 2023 Jun 22. doi: 10.1186/s12974-023-02824-8

PMCID:: PMC10286367

Abstract Article PDF–3.4M

Select item 100650785.

O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission

Jun Fan, Fang Guo, Ran Mo, Liang-Yu Chen, Jia-Wen Mo, Cheng-Lin Lu, Jing Ren, Qiu-Ling Zhong, Xiao-Jing Kuang, You-Lu Wen, Ting-Ting Gu, Jin-Ming Liu, Shu-Ji Li, Ying-Ying Fang, Cunyou Zhao, Tian-Ming Gao, Xiong Cao

J Clin Invest. 2023 Apr 3; 133(7): e160016. Published online 2023 Apr 3. doi: 10.1172/JCI160016

PMCID:: PMC10065078

Abstract Article PDF–4.3M

Select item 100326556.

O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitors

Zengdi Zhang, Zan Huang, Mohamed Awad, Mohammed Elsalanty, James Cray, Lauren E Ball, Jason C Maynard, Alma L Burlingame, Hu Zeng, Kim C Mansky, Hai-Bin Ruan

eLife. 2023; 12: e85464. Published online 2023 Mar 2. doi: 10.7554/eLife.85464

PMCID:: PMC10032655

Abstract Article PDF–15M

Select item 94328287.

Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity

Qi Wang, Bichen Zhang, Bernardo Stutz, Zhong-Wu Liu, Tamas L. Horvath, Xiaoyong Yang

Sci Adv. 2022 Sep; 8(35): eabn8092. Published online 2022 Aug 31. doi: 10.1126/sciadv.abn8092

PMCID:: PMC9432828

Abstract Article PDF–8.2M

Select item 85348238.

Pancreatic β-Cell O-GlcNAc Transferase Overexpression Increases Susceptibility to Metabolic Stressors in Female Mice

Ramkumar Mohan, Seokwon Jo, Elina Da Sol Chung, Eunice Oribamise, Amber Lockridge, Juan E. Abrahante-Lloréns, Hai-Bin Ruan, Xiao-Yong Yang, Emilyn U. Alejandro

Cells. 2021 Oct; 10(10): 2801. Published online 2021 Oct 19. doi: 10.3390/cells10102801

PMCID:: PMC8534823

Abstract Article PDF–3.9M

Select item 84057819.

Silencing of O-linked N-acetylglucosamine transferase ameliorates hypercalcemia-induced neurotoxicity in renal failure by regulating EZH2/KLF2/CXCL1 axis

Yaochen Cao, Xin Chen, Hongming Sun

Cell Death Dis. 2021 Sep; 12(9): 819. Published online 2021 Aug 30. doi: 10.1038/s41419-021-04022-x

PMCID:: PMC8405781

Abstract Article PDF–2.2M

Select item 826785110.

Disruption of O-Linked N-Acetylglucosamine Signaling in Placenta Induces Insulin Sensitivity in Female Offspring

Mackenzie Moore, Nandini Avula, Seokwon Jo, Megan Beetch, Emilyn U. Alejandro

Int J Mol Sci. 2021 Jul; 22(13): 6918. Published online 2021 Jun 28. doi: 10.3390/ijms22136918

PMCID:: PMC8267851

Abstract Article PDF–2.4M

Select item 764798011.

O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis

Fan Yu, Te Li, Yanchao Sui, Qingxia Chen, Song Yang, Jia Yang, Renjie Hong, Dengwen Li, Xiumin Yan, Wei Zhao, Xueliang Zhu, Jun Zhou

Protein Cell. 2020 Nov; 11(11): 852–857. Published online 2020 Jun 30. doi: 10.1007/s13238-020-00746-2

PMCID:: PMC7647980

Article PDF–1.7M

Select item 719946012.

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain

Elizabeth G. Wheatley, Eddy Albarran, Charles W. White, III, Gregor Bieri, Cesar Sanchez-Diaz, Karishma Pratt, Cedric E. Snethlage, Jun B. Ding, Saul A. Villeda

Curr Biol. Author manuscript; available in PMC 2020 May 5.

Published in final edited form as: Curr Biol. 2019 Oct 21; 29(20): 3359–3369.e4. Published online 2019 Oct 3. doi: 10.1016/j.cub.2019.08.003

PMCID:: PMC7199460

Abstract Article PDF–1.9M

Select item 694877413.

O-GlcNAc transferase suppresses necroptosis and liver fibrosis

Bichen Zhang, Min-Dian Li, Ruonan Yin, Yuyang Liu, Yunfan Yang, Kisha A. Mitchell-Richards, Jin Hyun Nam, Rui Li, Li Wang, Yasuko Iwakiri, Dongjun Chung, Marie E. Robert, Barbara E. Ehrlich, Anton M. Bennett, Jun Yu, Michael H. Nathanson, Xiaoyong Yang

JCI Insight. 2019 Nov 1; 4(21): e127709. Published online 2019 Nov 1. doi: 10.1172/jci.insight.127709

PMCID:: PMC6948774

Abstract Article PDF–12M

Select item 600135914.

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

Hao Shi, Alexander Munk, Thomas S. Nielsen, Morgan R. Daughtry, Louise Larsson, Shize Li, Kasper F. Høyer, Hannah W. Geisler, Karolina Sulek, Rasmus Kjøbsted, Taylor Fisher, Marianne M. Andersen, Zhengxing Shen, Ulrik K. Hansen, Eric M. England, Zhiyong Cheng, Kurt Højlund, Jørgen F.P. Wojtaszewski, Xiaoyong Yang, Matthew W. Hulver, Richard F. Helm, Jonas T. Treebak, David E. Gerrard

Mol Metab. 2018 May; 11: 160–177. Published online 2018 Feb 24. doi: 10.1016/j.molmet.2018.02.010

PMCID:: PMC6001359

Abstract Article PDF–2.5M

Select item 559267215.

Sustained O-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism

Ee Phie Tan, Steven R. McGreal, Stefan Graw, Robert Tessman, Scott J. Koppel, Pramod Dhakal, Zhen Zhang, Miranda Machacek, Natasha E. Zachara, Devin C. Koestler, Kenneth R. Peterson, John P. Thyfault, Russell H. Swerdlow, Partha Krishnamurthy, Luciano DiTacchio, Udayan Apte, Chad Slawson

J Biol Chem. 2017 Sep 8; 292(36): 14940–14962. Published online 2017 Jul 24. doi: 10.1074/jbc.M117.797944

PMCID:: PMC5592672

Abstract Article PDF–7.3M

Select item 532099316.

O-GlcNAc transferase regulates excitatory synapse maturity

Olof Lagerlöf, Gerald W. Hart, Richard L. Huganir

Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7): 1684–1689. Published online 2017 Jan 31. doi: 10.1073/pnas.1621367114

PMCID:: PMC5320993

Abstract Article PDF–1.1M

Select item 503924517.

Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity

Sungsu Kim, Jason C. Maynard, Yo Sasaki, Amy Strickland, Diane L. Sherman, Peter J. Brophy, Alma L. Burlingame, Jeffrey Milbrandt

J Neurosci. 2016 Sep 14; 36(37): 9633–9646. doi: 10.1523/JNEUROSCI.1235-16.2016

PMCID:: PMC5039245

Abstract Article PDF–4.7M

Select item 485492618.

O‐GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

Shutao Xie, Nana Jin, Jianlan Gu, Jianhua Shi, Jianming Sun, Dandan Chu, Liang Zhang, Chun‐ling Dai, Jin‐hua Gu, Cheng‐Xin Gong, Khalid Iqbal, Fei Liu

Aging Cell. 2016 Jun; 15(3): 455–464. Published online 2016 Feb 3. doi: 10.1111/acel.12449

PMCID:: PMC4854926

Abstract Article PDF–1.2M

Select item 464387419.

O-GlcNAcylation Negatively Regulates Cardiomyogenic Fate in Adult Mouse Cardiac Mesenchymal Stromal Cells

Ayesha Zafir, James A. Bradley, Bethany W. Long, Senthilkumar Muthusamy, Qianhong Li, Bradford G. Hill, Marcin Wysoczynski, Sumanth D. Prabhu, Aruni Bhatnagar, Roberto Bolli, Steven P. Jones

PLoS One. 2015; 10(11): e0142939. Published online 2015 Nov 13. doi: 10.1371/journal.pone.0142939

PMCID:: PMC4643874

Abstract Article PDF–924K

Select item 413359120.

Proteasomal degradation of O-GlcNAc transferase elevates hypoxia-induced vascular endothelial inflammatory response

Hongtao Liu, Zhongxiao Wang, Shujie Yu, Jian Xu

Cardiovasc Res. 2014 Jul 1; 103(1): 131–139. Published online 2014 Apr 29. doi: 10.1093/cvr/cvu116

PMCID:: PMC4133591

Abstract Article PDF–1.2M

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