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Select item 81375841.

In vivo imaging of methionine aminopeptidase II for prostate cancer risk stratification

Jinghang Xie, Meghan A. Rice, Zixin Chen, Yunfeng Cheng, En-Chi Hsu, Min Chen, Guosheng Song, Liyang Cui, Kaixiang Zhou, Jessa B. Castillo, Chiyuan A. Zhang, Bin Shen, Frederick T. Chin, Christian A. Kunder, James D. Brooks, Tanya Stoyanova, Jianghong Rao

Cancer Res. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Cancer Res. 2021 May 1; 81(9): 2510–2521. Published online 2021 Feb 26. doi: 10.1158/0008-5472.CAN-20-2969

PMCID:: PMC8137584

Abstract Article PDF–1.1M

Select item 40315542.

Redox Regulation of Methionine Aminopeptidase 2 Activity

Joyce Chiu, Jason W. H. Wong, Philip J. Hogg

J Biol Chem. 2014 May 23; 289(21): 15035–15043. Published online 2014 Apr 3. doi: 10.1074/jbc.M114.554253

PMCID:: PMC4031554

Abstract Article PDF–1.2M

Select item 39449993.

Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesity

Amit A Joharapurkar, Nirav A Dhanesha, Mukul R Jain

Diabetes Metab Syndr Obes. 2014; 7: 73–84. Published online 2014 Feb 28. doi: 10.2147/DMSO.S56924

PMCID:: PMC3944999

Abstract Article PDF–345K

Select item 18505714.

Methionine Aminopeptidase-2 Regulates Human Mesothelioma Cell Survival : Role of Bcl-2 Expression and Telomerase Activity

Alfonso Catalano, Mario Romano, Iole Robuffo, Luigi Strizzi, Antonio Procopio

Am J Pathol. 2001 Aug; 159(2): 721–731. doi: 10.1016/S0002-9440(10)61743-9

PMCID:: PMC1850571

Abstract Article PDF–629K

Select item 280175.

Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2

Eric C. Griffith, Zhuang Su, Satomi Niwayama, Cameron A. Ramsay, Yie-Hwa Chang, Jun O. Liu

Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26): 15183–15188. doi: 10.1073/pnas.95.26.15183

PMCID:: PMC28017

Abstract Article PDF–191K

Select item 210086.

The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2

Ny Sin, Lihao Meng, Margaret Q. W. Wang, James J. Wen, William G. Bornmann, Craig M. Crews

Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12): 6099–6103. doi: 10.1073/pnas.94.12.6099

PMCID:: PMC21008

Abstract Article PDF–326K

Select item 74846507.

CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2

Wei-Peng He, Yun-Yun Guo, Gui-Ping Yang, Hui-Ling Lai, Ting-Ting Sun, Zu -Wei Zhang, Ling-Long Ouyang, Yu Zheng, Li-Ming Tian, Xiao-Hui Li, Ze-Shan You, Dan Xie, Guo-Fen Yang

Int J Med Sci. 2020; 17(15): 2387–2395. Published online 2020 Aug 29. doi: 10.7150/ijms.48615

PMCID:: PMC7484650

Abstract Article PDF–1.5M

Select item 53253658.

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

Frédéric Frottin, Willy V. Bienvenut, Jérôme Bignon, Eric Jacquet, Alvaro Sebastian Vaca Jacome, Alain Van Dorsselaer, Sarah Cianferani, Christine Carapito, Thierry Meinnel, Carmela Giglione

Oncotarget. 2016 Sep 27; 7(39): 63306–63323. Published online 2016 Aug 11. doi: 10.18632/oncotarget.11216

PMCID:: PMC5325365

Abstract Article PDF–2.6M

Select item 29067549.

Protein N-Terminal Processing: Substrate Specificity of Escherichia coli and Human Methionine Aminopeptidases

Qing Xiao, Feiran Zhang, Benjamin A. Nacev, Jun O. Liu, Dehua Pei

Biochemistry. Author manuscript; available in PMC 2011 Jul 6.

Published in final edited form as: Biochemistry. 2010 Jul 6; 49(26): 5588–5599. doi: 10.1021/bi1005464

PMCID:: PMC2906754

Abstract Article PDF–2.0M

Select item 274084910.

NC2213: a novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells

Ponniah Selvakumar, Ashakumary Lakshmikuttyamma, Umashankar Das, Hari N Pati, Jonathan R Dimmock, Rajendra K Sharma

Mol Cancer. 2009; 8: 65. Published online 2009 Aug 24. doi: 10.1186/1476-4598-8-65

PMCID:: PMC2740849

Abstract Article PDF–1.0M

Select item 1085748111.

Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons

Saranya Santhosh Kumar, Nima N. Naseri, Sarshan R. Pather, Erinc Hallacli, Alain Ndayisaba, Chris Buenaventura, Karen Acosta, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Kelvin Luk, Vikram Khurana, Elizabeth Rhoades, Ophir Shalem

Sci Adv. 2024 Feb 9; 10(6): eadj4767. Published online 2024 Feb 9. doi: 10.1126/sciadv.adj4767

PMCID:: PMC10857481

Abstract Article PDF–8.8M

Select item 353442112.

MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2

Cheng-Ying Ho, Eli Bar, Caterina Giannini, Luigi Marchionni, Matthias A. Karajannis, David Zagzag, David H. Gutmann, Charles G. Eberhart, Fausto J. Rodriguez

Neuro Oncol. 2013 Jan; 15(1): 69–82. Published online 2012 Nov 15. doi: 10.1093/neuonc/nos269

PMCID:: PMC3534421

Abstract Article PDF–434K

Select item 4121613.

Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.

S M Arfin, R L Kendall, L Hall, L H Weaver, A E Stewart, B W Matthews, R A Bradshaw

Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17): 7714–7718. doi: 10.1073/pnas.92.17.7714

PMCID:: PMC41216

Summary Page Browse PDF–1.4M

Select item 275879114.

DEPTOR is an mTOR Inhibitor Whose Frequent Overexpression in Multiple Myeloma Cells Promotes their Survival

Timothy R. Peterson, Mathieu Laplante, Carson C. Thoreen, Yasemin Sancak, Seong A. Kang, W. Michael Kuehl, Nathanael S. Gray, David M. Sabatini

Cell. Author manuscript; available in PMC 2010 May 29.

Published in final edited form as: Cell. 2009 May 29; 137(5): 873–886. Published online 2009 May 14. doi: 10.1016/j.cell.2009.03.046

PMCID:: PMC2758791

Abstract Article PDF–3.3M

Select item 148059515.

Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest

Jing-Ruey J. Yeh, Rong Ju, Cathleen M. Brdlik, Wenjun Zhang, Yi Zhang, Mary E. Matyskiela, Joseph D. Shotwell, Craig M. Crews

Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27): 10379–10384. Published online 2006 Jun 21. doi: 10.1073/pnas.0511313103

PMCID:: PMC1480595

Abstract Article PDF–1.4M

Select item 232327016.

cdc2–cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner

Ewan M Smith, Christopher G Proud

EMBO J. 2008 Apr 9; 27(7): 1005–1016. Published online 2008 Mar 13. doi: 10.1038/emboj.2008.39

PMCID:: PMC2323270

Abstract Article PDF–367K

Select item 334286217.

Methionine aminopeptidase 2 is required for HSC initiation and proliferation

Alvin C. H. Ma, Tsz K. Fung, Rachel H. C. Lin, Martin I. S. Chung, Dan Yang, Stephen C. Ekker, Anskar Y. H. Leung

Blood. 2011 Nov 17; 118(20): 5448–5457. Prepublished online 2011 Sep 21. doi: 10.1182/blood-2011-04-350173

PMCID:: PMC3342862

Abstract Article

Select item 291474118.

Genetic Variation and Antioxidant Response Gene Expression in the Bronchial Airway Epithelium of Smokers at Risk for Lung Cancer

Xuting Wang, Brian N. Chorley, Gary S. Pittman, Steven R. Kleeberger, John Brothers, II, Gang Liu, Avrum Spira, Douglas A. Bell

PLoS One. 2010; 5(8): e11934. Published online 2010 Aug 3. doi: 10.1371/journal.pone.0011934

PMCID:: PMC2914741

Abstract Article PDF–1.3M

Select item 732004319.

Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation

Bethany Mason, Susanne Flach, Felipe R. Teixeira, Raquel Manzano Garcia, Oscar M. Rueda, Jean E. Abraham, Carlos Caldas, Paul A. W. Edwards, Heike Laman

Cell Mol Life Sci. 2020 Jul; 77(13): 2605–2620. Published online 2019 Sep 27. doi: 10.1007/s00018-019-03306-y