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Select item 83493181.

An E3 Ubiquitin Ligase RNF139 Serves as a Tumor-Suppressor in Glioma

Xiaofeng Chen, Weiping Kuang, Yong Zhu, Bin Zhou, Xiaosong Li, Xi Zhang, Bo Li, Liang Li, Shucheng Zou

J Mol Neurosci. 2021; 71(8): 1664–1673. Published online 2021 Jun 9. doi: 10.1007/s12031-021-01860-4

PMCID:: PMC8349318

Abstract Article PDF–7.8M

Select item 54930002.

E3 ubiquitin ligase, RNF139, inhibits the progression of tongue cancer

Lina Wang, Wei Yin, Chun Shi

BMC Cancer. 2017; 17: 452. Published online 2017 Jun 29. doi: 10.1186/s12885-017-3438-7

PMCID:: PMC5493000

Abstract Article PDF–1.9M

Select item 46781113.

Identifying the ERAD ubiquitin E3 ligases for viral and cellular targeting of MHC class I

D.J.H. van den Boomen, P.J. Lehner

Mol Immunol. 2015 Dec; 68(2): 106–111. doi: 10.1016/j.molimm.2015.07.005

PMCID:: PMC4678111

Abstract Article PDF–1002K

Select item 63692744.

Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8

You Zhang, Jing Lu, Jing Ma, Xinqi Liu

J Biol Chem. 2019 Feb 8; 294(6): 2046–2059. Published online 2018 Dec 18. doi: 10.1074/jbc.RA118.004630

PMCID:: PMC6369274

Abstract Article PDF–4.0M

Select item 59347665.

MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins

Sandra Stefanovic‐Barrett, Anna S Dickson, Stephen P Burr, James C Williamson, Ian T Lobb, Dick JH van den Boomen, Paul J Lehner, James A Nathan

EMBO Rep. 2018 May; 19(5): e45603. Published online 2018 Mar 8. doi: 10.15252/embr.201745603

PMCID:: PMC5934766

Abstract Article PDF–4.7M

Select item 27421906.

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

Helen R. Stagg, Mair Thomas, Dick van den Boomen, Emmanuel J.H.J. Wiertz, Harry A. Drabkin, Robert M. Gemmill, Paul J. Lehner

J Cell Biol. 2009 Sep 7; 186(5): 685–692. doi: 10.1083/jcb.200906110

PMCID:: PMC2742190

Abstract Article PDF–3.6M

Select item 213807.

The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8

Robert M. Gemmill, James D. West, Ferenc Boldog, Naotake Tanaka, Linda J. Robinson, David I. Smith, Frederick Li, Harry A. Drabkin

Proc Natl Acad Sci U S A. 1998 Aug 4; 95(16): 9572–9577. doi: 10.1073/pnas.95.16.9572

PMCID:: PMC21380

Abstract Article PDF–293K

Select item 32511578.

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8

Youngah Jo, Peter C. W. Lee, Peter V. Sguigna, Russell A. DeBose-Boyd

Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51): 20503-20508. Published online 2011 Dec 5. doi: 10.1073/pnas.1112831108

PMCID:: PMC3251157

Abstract Article PDF–1.0M

Select item 27814469.

The Sterol-sensing Endoplasmic Reticulum (ER) Membrane Protein TRC8 Hampers ER to Golgi Transport of Sterol Regulatory Element-binding Protein-2 (SREBP-2)/SREBP Cleavage-activated Protein and Reduces SREBP-2 Cleavage

Masato Irisawa, Jun Inoue, Nozomi Ozawa, Kazutoshi Mori, Ryuichiro Sato

J Biol Chem. 2009 Oct 16; 284(42): 28995–29004. Published online 2009 Aug 25. doi: 10.1074/jbc.M109.041376

PMCID:: PMC2781446

Abstract Article PDF–959K

Select item 531310110.

Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels

Christine Hantouche, Brittany Williamson, William C. Valinsky, Joshua Solomon, Alvin Shrier, Jason C. Young

J Biol Chem. 2017 Feb 10; 292(6): 2287–2300. Published online 2016 Dec 20. doi: 10.1074/jbc.M116.752618

PMCID:: PMC5313101

Abstract Article PDF–2.6M

Select item 356453811.

Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet–associated endoplasmic reticulum membranes

Youngah Jo, Isamu Z. Hartman, Russell A. DeBose-Boyd

Mol Biol Cell. 2013 Feb 1; 24(3): 169–183. doi: 10.1091/mbc.E12-07-0564

PMCID:: PMC3564538

Abstract Article PDF–3.6M

Select item 428340712.

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

Chia-yi Chen, Nicole S Malchus, Beate Hehn, Walter Stelzer, Dönem Avci, Dieter Langosch, Marius K Lemberg

EMBO J. 2014 Nov 3; 33(21): 2492–2506. Published online 2014 Sep 19. doi: 10.15252/embj.201488208

PMCID:: PMC4283407

Abstract Article PDF–1.7M

Select item 308682513.

TRC8, A KIDNEY CANCER-ASSOCIATED UBIQUITIN LIGASE, IS STEROL-REGULATED AND INTERACTS WITH LIPID AND PROTEIN BIOSYNTHETIC PATHWAYS

Jason P. Lee, Anne Brauweiler, Michael Rudolph, Joan E. Hooper, Harry A. Drabkin, Robert M. Gemmill

Mol Cancer Res. Author manuscript; available in PMC 2011 May 3.

Published in final edited form as: Mol Cancer Res. 2010 Jan; 8(1): 93–106. Published online 2010 Jan 12. doi: 10.1158/1541-7786.MCR-08-0491

PMCID:: PMC3086825

Abstract Article PDF–3.1M

Select item 1803914.

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

Kevin L. Lorick, Jane P. Jensen, Shengyun Fang, Albert M. Ong, Shigetsugu Hatakeyama, Allan M. Weissman

Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20): 11364–11369. doi: 10.1073/pnas.96.20.11364

PMCID:: PMC18039

Abstract Article PDF–354K

Select item 308320715.

Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase

Youngah Jo, Peter V. Sguigna, Russell A. DeBose-Boyd

J Biol Chem. 2011 Apr 29; 286(17): 15022–15031. Published online 2011 Feb 22. doi: 10.1074/jbc.M110.211326

PMCID:: PMC3083207

Abstract Article PDF–1.4M

Select item 705316916.

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment

Sathish Kumar, Rina Barouch-Bentov, Fei Xiao, Stanford Schor, Szuyuan Pu, Elise Biquand, Albert Lu, Brett D. Lindenbach, Yves Jacob, Caroline Demeret, Shirit Einav

Cell Rep. Author manuscript; available in PMC 2020 Mar 3.

Published in final edited form as: Cell Rep. 2019 Feb 12; 26(7): 1800–1814.e5. doi: 10.1016/j.celrep.2019.01.075

PMCID:: PMC7053169

Abstract Article PDF–2.3M

Select item 273665217.

A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system

Sjoerd J L van Wijk, Sjoerd J de Vries, Patrick Kemmeren, Anding Huang, Rolf Boelens, Alexandre M J J Bonvin, H Th Marc Timmers

Mol Syst Biol. 2009; 5: 295. Published online 2009 Aug 18. doi: 10.1038/msb.2009.55

Correction in:: Mol Syst Biol. 2009; 5: 317.

PMCID:: PMC2736652

Abstract Article PDF–5.6M

Select item 276528018.

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

Gabriel Markson, Christina Kiel, Russell Hyde, Stephanie Brown, Panagoula Charalabous, Anja Bremm, Jennifer Semple, Jonathan Woodsmith, Simon Duley, Kourosh Salehi-Ashtiani, Marc Vidal, David Komander, Luis Serrano, Paul Lehner, Christopher M. Sanderson

Genome Res. 2009 Oct; 19(10): 1905–1911. doi: 10.1101/gr.093963.109

PMCID:: PMC2765280

Abstract Article PDF–425K

Select item 727904919.

EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired

Marioara Chiritoiu, Gabriela N. Chiritoiu, Cristian V. A. Munteanu, Florin Pastrama, N. Erwin Ivessa, Stefana M. Petrescu

Int J Mol Sci. 2020 May; 21(10): 3468. Published online 2020 May 14. doi: 10.3390/ijms21103468

PMCID:: PMC7279049

Abstract Article PDF–12M

Select item 733229320.

Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

Emma J Fenech, Federica Lari, Philip D Charles, Roman Fischer, Marie Laétitia-Thézénas, Katrin Bagola, Adrienne W Paton, James C Paton, Mads Gyrd-Hansen, Benedikt M Kessler, John C Christianson

eLife. 2020; 9: e57306. Published online 2020 Jul 2. doi: 10.7554/eLife.57306