PMC Links for Gene (Select 117134593) - PMC

Select item 74187281.

Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells

Lanlan Zhou, Kelsey Huntington, Shengliang Zhang, Lindsey Carlsen, Eui-Young So, Cassandra Parker, Ilyas Sahin, Howard Safran, Suchitra Kamle, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Kerry S. Campbell, Mandar T. Naik, Walter J. Atwood, Emile Youssef, Jonathan A. Pachter, Arunasalam Navaraj, Attila A. Seyhan, Olin Liang, Wafik S. El-Deiry

Version 2. bioRxiv. Preprint. 2020 Aug 3 [revised 2020 Sep 2]. doi: 10.1101/2020.08.02.230839

PMCID:: PMC7418728

Abstract Article PDF–24M

Select item 72025332.

Jing Yang, Hongxia Li, Shengda Hu, Yafeng Zhou

Aging (Albany NY) 2020 Apr 30; 12(8): 6518–6535. Published online 2020 Apr 27. doi: 10.18632/aging.103100

PMCID:: PMC7202533

Abstract Article PDF–2.3M

Select item 56562623.

Forkhead Box Transcription Factors of the FOXA Class Are Required for Basal Transcription of Angiotensin-Converting Enzyme 2

Kim Brint Pedersen, Harshita Chodavarapu, Eric Lazartigues

J Endocr Soc. 2017 Apr 1; 1(4): 370–384. Published online 2017 Mar 6. doi: 10.1210/js.2016-1071

PMCID:: PMC5656262

Abstract Article PDF–1.9M

Select item 90053454.

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Julie E. Horowitz, Jack A. Kosmicki, Amy Damask, Deepika Sharma, Genevieve H. L. Roberts, Anne E. Justice, Nilanjana Banerjee, Marie V. Coignet, Ashish Yadav, Joseph B. Leader, Anthony Marcketta, Danny S. Park, Rouel Lanche, Evan Maxwell, Spencer C. Knight, Xiaodong Bai, Harendra Guturu, Dylan Sun, Asher Baltzell, Fabricio S. P. Kury, Joshua D. Backman, Ahna R. Girshick, Colm O’Dushlaine, Shannon R. McCurdy, Raghavendran Partha, Adam J. Mansfield, David A. Turissini, Alexander H. Li, Miao Zhang, Joelle Mbatchou, Kyoko Watanabe, Lauren Gurski, Shane E. McCarthy, Hyun M. Kang, Lee Dobbyn, Eli Stahl, Anurag Verma, Giorgio Sirugo, Regeneron Genetics Center, Marylyn D. Ritchie, Marcus Jones, Suganthi Balasubramanian, Katherine Siminovitch, William J. Salerno, Alan R. Shuldiner, Daniel J. Rader, Tooraj Mirshahi, Adam E. Locke, Jonathan Marchini, John D. Overton, David J. Carey, Lukas Habegger, Michael N. Cantor, Kristin A. Rand, Eurie L. Hong, Jeffrey G. Reid, Catherine A. Ball, Aris Baras, Gonçalo R. Abecasis, Manuel A. R. Ferreira

Nat Genet. 2022; 54(4): 382–392. Published online 2022 Mar 3. doi: 10.1038/s41588-021-01006-7

PMCID:: PMC9005345

Abstract Article PDF–6.5M

Select item 75531845.

Regulation of the ACE2 locus in human airways cells

Hye Kyung Lee, Olive Jung, Lothar Hennighausen

Version 2. bioRxiv. Preprint. 2020 Oct 5 [revised 2020 Nov 6]. doi: 10.1101/2020.10.04.325415

PMCID:: PMC7553184

Abstract Article PDF–7.5M

Select item 74548886.

Vascular inflammation and endothelial injury in SARS-CoV-2 infection: The overlooked regulatory cascades implicated by the ACE2 gene cluster

Claire L Shovlin, Marcela P Vizcaychipi

QJM. 2020 Aug 10 : hcaa241. Published online 2020 Aug 10. doi: 10.1093/qjmed/hcaa241

PMCID:: PMC7454888

Abstract PDF–658K

Select item 74327777.

Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2

Marina Borro, Paolo Di Girolamo, Giovanna Gentile, Ottavia De Luca, Robert Preissner, Adriano Marcolongo, Stefano Ferracuti, Maurizio Simmaco

Int J Environ Res Public Health. 2020 Aug; 17(15): 5573. Published online 2020 Aug 2. doi: 10.3390/ijerph17155573

PMCID:: PMC7432777

Abstract Article PDF–2.0M

Select item 72956308.

Physiological cyclic stretch up-regulates angiotensin-converting enzyme 2 expression to reduce proliferation and migration of vascular smooth muscle cells

Jiantao Song, Haiyan Qu, Bo Hu, Chenglong Bi, Mengmeng Li, Lin Wang, Xiaozhen Huang, Mei Zhang

Biosci Rep. 2020 Jun 26; 40(6): BSR20192012. Published online 2020 Jun 15. doi: 10.1042/BSR20192012

PMCID:: PMC7295630

Abstract Article PDF–1.5M

Select item 93775239.

Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

Olusegun O. Onabajo, A. Rouf Banday, Megan L. Stanifer, Wusheng Yan, Adeola Obajemu, Deanna M. Santer, Oscar Florez-Vargas, Helen Piontkivska, Joselin M. Vargas, Timothy J. Ring, Carmon Kee, Patricio Doldan, D. Lorne Tyrrell, Juan L. Mendoza, Steeve Boulant, Ludmila Prokunina-Olsson

Nat Genet. Author manuscript; available in PMC 2022 Aug 15.

Published in final edited form as: Nat Genet. 2020 Dec; 52(12): 1283–1293. Published online 2020 Oct 19. doi: 10.1038/s41588-020-00731-9

PMCID:: PMC9377523

Abstract Article PDF–6.0M

Select item 759275310.

Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2

Harlan Barker, Seppo Parkkila

PLoS One. 2020; 15(10): e0240647. Published online 2020 Oct 28. doi: 10.1371/journal.pone.0240647

PMCID:: PMC7592753

Abstract Article PDF–4.0M

Select item 756064311.

Assessing the consequences of environmental exposures on the expression of the human receptor and proteases involved in SARS-CoV-2 cell-entry

Manon Watzky, Maud de Dieuleveult, Anne Letessier, Claude Saint-Ruf, Benoit Miotto

Environ Res. 2021 Apr; 195: 110317. Published online 2020 Oct 15. doi: 10.1016/j.envres.2020.110317

PMCID:: PMC7560643

Abstract Article PDF–2.5M

Select item 738649412.

Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2

Olusegun O. Onabajo, A. Rouf Banday, Wusheng Yan, Adeola Obajemu, Megan L. Stanifer, Deanna M. Santer, Oscar Florez-Vargas, Helen Piontkivska, Joselin Vargas, Carmon Kee, D. Lorne J. Tyrrell, Juan L. Mendoza, Steeve Boulant, Ludmila Prokunina-Olsson

Version 1. bioRxiv. Preprint. 2020 Jul 20. doi: 10.1101/2020.07.19.210955

Published in:: Nat Genet. 2020 Dec; 52(12): 1283–1293.

PMCID:: PMC7386494

Abstract Article PDF–1.5M

Select item 714485413.

EZH2-mediated H3K27me3 inhibits ACE2 expression

Yuanyuan Li, Honggang Li, Liquan Zhou

Biochem Biophys Res Commun. 2020 Jun 11; 526(4): 947–952. Published online 2020 Apr 8. doi: 10.1016/j.bbrc.2020.04.010

PMCID:: PMC7144854

Abstract Article PDF–978K

Select item 383885714.

The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs

Kim Brint Pedersen, Kavaljit H. Chhabra, Van K. Nguyen, Huijing Xia, Eric Lazartigues

Biochim Biophys Acta. Author manuscript; available in PMC 2014 Nov 1.

Published in final edited form as: Biochim Biophys Acta. 2013 Nov; 1829(11): 10.1016/j.bbagrm.2013.09.007. Published online 2013 Oct 5. doi: 10.1016/j.bbagrm.2013.09.007

PMCID:: PMC3838857

Abstract Article PDF–3.2M

Select item 736618015.

Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue

Jennifer A. Aguiar, Benjamin J-M. Tremblay, Michael J. Mansfield, Owen Woody, Briallen Lobb, Arinjay Banerjee, Abiram Chandiramohan, Nicholas Tiessen, Quynh Cao, Anna Dvorkin-Gheva, Spencer Revill, Matthew S. Miller, Christopher Carlsten, Louise Organ, Chitra Joseph, Alison John, Paul Hanson, Richard C. Austin, Bruce M. McManus, Gisli Jenkins, Karen Mossman, Kjetil Ask, Andrew C. Doxey, Jeremy A. Hirota

Eur Respir J. 2020 Sep; 56(3): 2001123. Published online 2020 Sep 3. doi: 10.1183/13993003.01123-2020

PMCID:: PMC7366180

Abstract Article PDF–3.6M

Select item 935256916.

A first update on mapping the human genetic architecture of COVID-19

COVID-19 Host Genetics Initiative

Nature. 2022; 608(7921): E1–E10. Published online 2022 Aug 3. doi: 10.1038/s41586-022-04826-7

PMCID:: PMC9352569

Article PDF–3.3M

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