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Items: 1 to 20 of 39

1.
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor
Tyler Funnell, Shinya Tasaki, Arusha Oloumi, Shinsuke Araki, Esther Kong, Damian Yap, Yusuke Nakayama, Christopher S. Hughes, S.-W. Grace Cheng, Hirokazu Tozaki, Misa Iwatani, Satoshi Sasaki, Tomohiro Ohashi, Tohru Miyazaki, Nao Morishita, Daisuke Morishita, Mari Ogasawara-Shimizu, Momoko Ohori, Shoichi Nakao, Masatoshi Karashima, Masaya Sano, Aiko Murai, Toshiyuki Nomura, Noriko Uchiyama, Tomohiro Kawamoto, Ryujiro Hara, Osamu Nakanishi, Karey Shumansky, Jamie Rosner, Adrian Wan, Steven McKinney, Gregg B. Morin, Atsushi Nakanishi, Sohrab Shah, Hiroyoshi Toyoshiba, Samuel Aparicio
Nat Commun. 2017; 8: 7. Published online 2017 Feb 23. doi: 10.1038/s41467-016-0008-7
PMCID:
PMC5431906
AbstractArticlePDF–1.4M
2.
Nuclear Protein Kinase CLK1 Uses A Nontraditional Docking Mechanism To Select Physiological Substrates
Malik M. Keshwani, Kendra L. Hailey, Brandon E. Aubol, Laurent Fattet, Maria L. McGlone, Patricia A. Jennings, Joseph A. Adams
Biochem J. Author manuscript; available in PMC 2016 Dec 15.
Published in final edited form as: Biochem J. 2015 Dec 15; 472(3): 329–338. Published online 2015 Oct 6. doi: 10.1042/BJ20150903
PMCID:
PMC5053023
AbstractArticlePDF–1.4M
3.
An extensive program of periodic alternative splicing linked to cell cycle progression
Daniel Dominguez, Yi-Hsuan Tsai, Robert Weatheritt, Yang Wang, Benjamin J Blencowe, Zefeng Wang
eLife. 2016; 5: e10288. Published online 2016 Mar 25. doi: 10.7554/eLife.10288
PMCID:
PMC4884079
AbstractArticlePDF–3.0M
4.
Regulation and Substrate Specificity of the SR Protein Kinase Clk/Sty
Jayendra Prasad, James L. Manley
Mol Cell Biol. 2003 Jun; 23(12): 4139–4149. doi: 10.1128/MCB.23.12.4139-4149.2003
PMCID:
PMC156123
AbstractArticlePDF–306K
5.
Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders
Elizabeth K. J. Hogg, Greg M. Findlay
FEBS Lett. 2023 Oct; 597(19): 2375–2415. Published online 2023 Sep 4. doi: 10.1002/1873-3468.14723
PMCID:
PMC10952393
AbstractArticlePDF–1.9M
6.
CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly
Brandon E. Aubol, Jacob M. Wozniak, Laurent Fattet, David J. Gonzalez, Joseph A. Adams
Proc Natl Acad Sci U S A. 2021 Apr 6; 118(14): e2018251118. Published online 2021 Apr 2. doi: 10.1073/pnas.2018251118
PMCID:
PMC8040622
AbstractArticlePDF–4.3M
7.
LncRNA‐dependent nuclear stress bodies promote intron retention through SR protein phosphorylation
Kensuke Ninomiya, Shungo Adachi, Tohru Natsume, Junichi Iwakiri, Goro Terai, Kiyoshi Asai, Tetsuro Hirose
EMBO J. 2020 Feb 3; 39(3): e102729. Published online 2019 Nov 29. doi: 10.15252/embj.2019102729
PMCID:
PMC6996502
AbstractArticlePDF–2.0M
8.
N-Terminus of the Protein Kinase CLK1 Induces SR Protein Hyper-Phosphorylation
Brandon E. Aubol, Ryan M. Plocinik, Malik M. Keshwani, Maria L. McGlone, Jonathan C. Hagopian, Gourisankar Ghosh, Xiang-Dong Fu, Joseph A. Adams
Biochem J. Author manuscript; available in PMC 2016 Oct 10.
Published in final edited form as: Biochem J. 2014 Aug 15; 462(1): 143–152. doi: 10.1042/BJ20140494
PMCID:
PMC5056641
AbstractArticlePDF–1.5M
9.
Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing
Brandon E. Aubol, Guowei Wu, Malik M. Keshwani, Maliheh Movassat, Laurent Fattet, Klemens J. Hertel, Xiang-Dong Fu, Joseph A. Adams
Mol Cell. Author manuscript; available in PMC 2017 Jul 21.
Published in final edited form as: Mol Cell. 2016 Jul 21; 63(2): 218–228. Published online 2016 Jul 7. doi: 10.1016/j.molcel.2016.05.034
PMCID:
PMC4941815
AbstractArticlePDF–925K
10.
Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy
Raymond Wong, Ahalya Balachandran, Annie YQ Mao, Wendy Dobson, Scott Gray-Owen, Alan Cochrane
Retrovirology. 2011; 8: 47. Published online 2011 Jun 17. doi: 10.1186/1742-4690-8-47
PMCID:
PMC3148977
AbstractArticlePDF–3.6M
11.
Differential effects of hyperphosphorylation on splicing factor SRp55.
Ming-Chih Lai, Ru-Inn Lin, Woan-Yuh Tarn
Biochem J. 2003 May 1; 371(Pt 3): 937–945. doi: 10.1042/BJ20021827
PMCID:
PMC1223332
SummaryPDF–294K
12.
Disordered protein interactions for an ordered cellular transition: Cdc2-like kinase 1 is transported to the nucleus via its Ser–Arg protein substrate
Athira George, Brandon E. Aubol, Laurent Fattet, Joseph A. Adams
J Biol Chem. 2019 Jun 14; 294(24): 9631–9641. Published online 2019 May 7. doi: 10.1074/jbc.RA119.008463
PMCID:
PMC6579451
AbstractArticlePDF–3.0M
13.
Mobilization of A Splicing Factor Through A Nuclear Kinase-Kinase Complex
Brandon E. Aubol, Malik M. Keshwani, Laurent Fattet, Joseph A. Adams
Biochem J. Author manuscript; available in PMC 2019 Feb 14.
Published in final edited form as: Biochem J. 2018 Feb 14; 475(3): 677–690. Published online 2018 Feb 14. doi: 10.1042/BCJ20170672
PMCID:
PMC6293969
AbstractArticlePDF–2.1M
14.
Conserved Proline-Directed Phosphorylation Regulates SR Protein Conformation and Splicing Function
Malik M. Keshwani, Brandon E. Aubol, Laurent Fattet, Chen-Ting Ma, Jinsong Qiu, Patricia A. Jennings, Xiang-Dong Fu, Joseph A. Adams
Biochem J. Author manuscript; available in PMC 2016 Oct 6.
Published in final edited form as: Biochem J. 2015 Mar 1; 466(2): 311–322. doi: 10.1042/BJ20141373
PMCID:
PMC5053020
AbstractArticlePDF–1.5M
15.
Partitioning RS Domain Phosphorylation in an SR Protein through the CLK and SRPK Protein Kinases
Brandon E. Aubol, Ryan M. Plocinik, Jonathan C. Hagopian, Chen-Ting Ma, Maria L. McGlone, Reeti Bandyopadhyay, Xiang-Dong Fu, Joseph A. Adams
J Mol Biol. Author manuscript; available in PMC 2014 Aug 23.
Published in final edited form as: J Mol Biol. 2013 Aug 23; 425(16): 10.1016/j.jmb.2013.05.013. Published online 2013 May 23. doi: 10.1016/j.jmb.2013.05.013
PMCID:
PMC3860265
AbstractArticlePDF–2.4M
16.
Differential expression of 24,426 human alternative splicing events and predicted cis-regulation in 48 tissues and cell lines
John C. Castle, Chaolin Zhang, Jyoti K. Shah, Amit V. Kulkarni, Thomas A. Cooper, Jason M. Johnson
Nat Genet. Author manuscript; available in PMC 2011 Oct 20.
Published in final edited form as: Nat Genet. 2008 Dec; 40(12): 1416–1425. Published online 2008 Nov 2. doi: 10.1038/ng.264
PMCID:
PMC3197713
AbstractArticlePDF–2.8M
17.
Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint
Eleni Petsalaki, George Zachos
Nat Commun. 2016; 7: 11451. Published online 2016 Apr 29. doi: 10.1038/ncomms11451
PMCID:
PMC4855533
AbstractArticlePDF–4.1M
18.
The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.
K Colwill, T Pawson, B Andrews, J Prasad, J L Manley, J C Bell, P I Duncan
EMBO J. 1996 Jan 15; 15(2): 265–275.
PMCID:
PMC449941
SummaryPage BrowsePDF–2.5M
19.
A nuclear role for the respiratory enzyme CLK-1/COQ7 in regulating mitochondrial stress responses and longevity
Richard M. Monaghan, Robert G. Barnes, Kate Fisher, Tereza Andreou, Nicholas Rooney, Gino B. Poulin, Alan J. Whitmarsh
Nat Cell Biol. Author manuscript; available in PMC 2015 Dec 1.
Published in final edited form as: Nat Cell Biol. 2015 Jun; 17(6): 782–792. Published online 2015 May 11. doi: 10.1038/ncb3170
PMCID:
PMC4539581
AbstractArticlePDF–3.0M
20.
A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells
Muhammad Sohail, Lulzim Shkreta, Johanne Toutant, Safwat Rabea, Jean-Philippe Babeu, Caroline Huard, Jasmin Coulombe-Huntington, Aurélie Delannoy, Morgane Placet, Sameh Geha, Fernand-Pierre Gendron, François Boudreau, Mike Tyers, David S Grierson, Benoit Chabot
NAR Cancer. 2021 Jun; 3(2): zcab019. Published online 2021 May 25. doi: 10.1093/narcan/zcab019
PMCID:
PMC8210162
AbstractArticlePDF–5.8M

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