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Select item 110249221.

In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function

H. Yesid Estupiñán, Thibault Bouderlique, Chenfei He, Anna Berglöf, Andrea Cappelleri, Nicolai Frengen, Rula Zain, Mikael C. I. Karlsson, Robert Månsson, C. I. Edvard Smith

Blood Adv. 2024 Apr 23; 8(8): 1981–1990. Published online 2024 Mar 22. doi: 10.1182/bloodadvances.2024012706

PMCID:: PMC11024922

Abstract Article PDF–4.1M

Select item 107402992.

Bruton’s tyrosine kinase-bearing B cells and microglia in neuromyelitis optica spectrum disorder

Ye Liu, Zhenning Huang, Tian-Xiang Zhang, Bin Han, Guili Yang, Dongmei Jia, Li Yang, Qiang Liu, Alexander Y. L. Lau, Friedemann Paul, Alexei Verkhratsky, Fu-Dong Shi, Chao Zhang

J Neuroinflammation. 2023; 20: 309. Published online 2023 Dec 21. doi: 10.1186/s12974-023-02997-2

PMCID:: PMC10740299

Abstract Article PDF–9.5M

Select item 93610093.

Bruton's TK regulates myeloid cell recruitment during acute inflammation

Gareth S. D. Purvis, Haidee Aranda‐Tavio, Keith M. Channon, David R. Greaves

Br J Pharmacol. 2022 Jun; 179(11): 2754–2770. Published online 2022 Mar 15. doi: 10.1111/bph.15778

PMCID:: PMC9361009

Abstract Article PDF–12M

Select item 90021384.

Bruton’s Tyrosine Kinase Supports Gut Mucosal Immunity and Commensal Microbiome Recognition in Autoimmune Arthritis

Rachel H. Bonami, Christina E. Thurman, Sonam Verma, Camille S. Westlake, Lindsay E. Nyhoff, Bridgette B. Barron, Andrea Reboldi, Peggy L. Kendall

Front Immunol. 2022; 13: 748284. Published online 2022 Mar 29. doi: 10.3389/fimmu.2022.748284

PMCID:: PMC9002138

Abstract Article PDF–22M

Select item 86653245.

Bruton’s tyrosine kinase drives neuroinflammation and anxiogenic behavior in mouse models of stress

Simantini Ghosh, Zaidan Mohammed, Itender Singh

J Neuroinflammation. 2021; 18: 289. Published online 2021 Dec 11. doi: 10.1186/s12974-021-02322-9

PMCID:: PMC8665324

Abstract Article PDF–2.1M

Select item 86612276.

Knockout of Bruton’s tyrosine kinase in macrophages attenuates diabetic nephropathy in streptozotocin-induced mice

Zhe Fan, Yuanyuan Li, Lingling Xia, Yonggui Wu

Am J Transl Res. 2021; 13(11): 12352–12363. Published online 2021 Nov 15.

PMCID:: PMC8661227

Abstract Article PDF–1.7M

Select item 76084437.

T-cell expression of Bruton’s tyrosine kinase promotes autoreactive T-cell activation and exacerbates aplastic anemia

Simo Xia, Xiang Liu, Xuetao Cao, Sheng Xu

Cell Mol Immunol. 2020 Oct; 17(10): 1042–1052. Published online 2019 Aug 20. doi: 10.1038/s41423-019-0270-9

PMCID:: PMC7608443

Abstract Article PDF–3.0M

Select item 75802548.

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Madeeha H. Sheikh, Gustavo Ferreira Alves, Shireen Mohammad, Lauren A. Callender, Sina M. Coldewey, Massimo Collino, David R. Greaves, Christoph Thiemermann

Front Immunol. 2020; 11: 581758. Published online 2020 Oct 7. doi: 10.3389/fimmu.2020.581758

PMCID:: PMC7580254

Abstract Article PDF–2.3M

Select item 65611889.

Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization

Jean K. Chung, Laura M. Nocka, Aubrianna Decker, Qi Wang, Theresa A. Kadlecek, Arthur Weiss, John Kuriyan, Jay T. Groves

Proc Natl Acad Sci U S A. 2019 May 28; 116(22): 10798–10803. Published online 2019 May 10. doi: 10.1073/pnas.1819309116

PMCID:: PMC6561188

Abstract Article PDF–1.3M

Select item 613627710.

Distinct Roles for Bruton's Tyrosine Kinase in B Cell Immune Synapse Formation

Sara Roman-Garcia, Sara V. Merino-Cortes, Sofia R. Gardeta, Marjolein J. W. de Bruijn, Rudi W. Hendriks, Yolanda R. Carrasco

Front Immunol. 2018; 9: 2027. Published online 2018 Sep 6. doi: 10.3389/fimmu.2018.02027

PMCID:: PMC6136277

Abstract Article PDF–4.3M

Select item 576287811.

Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge

Giora I. Morozov, Nurith Porat, Tatyana Kushnir, Hastyar Najmuldeen, Asad Adawi, Vered Chalifa-Caspi, Rachel Benisty, Ariel Ohayon, Ofir Liron, Shalhevet Azriel, Itai Malka, Shahar Dotan, Maxim Portnoi, Andrew A. Piotrowski, Daniel Kafka, Barak Hajaj, Tali Fishilevich, Marilou Shagan, Michael Tal, Ron Ellis, Donald A. Morrison, Andrea M. Mitchell, Timothy J. Mitchell, Ron Dagan, Hasan Yesilkaya, Yaffa Mizrachi Nebenzahl

Sci Rep. 2018; 8: 314. Published online 2018 Jan 10. doi: 10.1038/s41598-017-18645-8

PMCID:: PMC5762878

Abstract Article PDF–1.9M

Select item 562911412.

Achieving a Graded Immune Response: BTK Adopts Range of Active/Inactive Conformations Dictated by Multiple Interdomain Contacts

Raji E. Joseph, Thomas E. Wales, D. Bruce Fulton, John R. Engen, Amy H. Andreotti

Structure. Author manuscript; available in PMC 2018 Oct 3.

Published in final edited form as: Structure. 2017 Oct 3; 25(10): 1481–1494.e4. Published online 2017 Aug 31. doi: 10.1016/j.str.2017.07.014

PMCID:: PMC5629114

Abstract Article PDF–1.2M

Select item 526314313.

Bruton’s tyrosine kinase inhibition attenuates liver damage in a mouse warm ischemia and reperfusion model

T Palumbo, K Nakamura, C Lassman, Y Kidani, SJ Bensinger, RW Busuttil, JW Kupiec-Weglinski, A Zarrinpar

Transplantation. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Transplantation. 2017 Feb; 101(2): 322–331. doi: 10.1097/TP.0000000000001552

PMCID:: PMC5263143

Abstract Article PDF–829K

Select item 416678614.

Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury

Agnieszka Krupa, Marek Fol, Moshiur Rahman, Karen Y. Stokes, Jon M. Florence, Igor L. Leskov, Mikhail V. Khoretonenko, Michael A. Matthay, Kathleen D. Liu, Carolyn S. Calfee, Amy Tvinnereim, Gabriel R. Rosenfield, Anna K. Kurdowska

Am J Physiol Lung Cell Mol Physiol. 2014 Sep 15; 307(6): L435–L448. Published online 2014 Aug 1. doi: 10.1152/ajplung.00234.2013

PMCID:: PMC4166786

Abstract Article

Select item 415120215.

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model

Burcu Bestas, Pedro M.D. Moreno, K. Emelie M. Blomberg, Dara K. Mohammad, Amer F. Saleh, Tolga Sutlu, Joel Z. Nordin, Peter Guterstam, Manuela O. Gustafsson, Shabnam Kharazi, Barbara Piątosa, Thomas C. Roberts, Mark A. Behlke, Matthew J.A. Wood, Michael J. Gait, Karin E. Lundin, Samir El Andaloussi, Robert Månsson, Anna Berglöf, Jesper Wengel, C.I. Edvard Smith

J Clin Invest. 2014 Sep 2; 124(9): 4067–4081. Published online 2014 Aug 8. doi: 10.1172/JCI76175

PMCID:: PMC4151202

Abstract Article PDF–1.8M

Select item 408374916.

Bruton’s Tyrosine Kinase Promotes Persistence of Mature Anti-Insulin B Cells

Rachel H. Bonami, Allison M. Sullivan, James B. Case, Hannah E. Steinberg, Kristen L. Hoek, Wasif N. Khan, Peggy L. Kendall

J Immunol. Author manuscript; available in PMC 2015 Feb 15.

Published in final edited form as: J Immunol. 2014 Feb 15; 192(4): 1459–1470. Published online 2014 Jan 22. doi: 10.4049/jimmunol.1300125

PMCID:: PMC4083749

Abstract Article PDF–2.7M

Select item 389753017.

Btk Regulates Macrophage Polarization in Response to Lipopolysaccharide

Joan Ní Gabhann, Emily Hams, Siobhán Smith, Claire Wynne, Jennifer C. Byrne, Kiva Brennan, Shaun Spence, Adrien Kissenpfennig, James A. Johnston, Padraic G. Fallon, Caroline A. Jefferies

PLoS One. 2014; 9(1): e85834. Published online 2014 Jan 21. doi: 10.1371/journal.pone.0085834

PMCID:: PMC3897530

Abstract Article PDF–2.3M

Select item 380006518.

The role of Bruton's tyrosine kinase in the development and BCR/TLR-dependent activation of AM14 rheumatoid factor B cells

Kerstin Nündel, Patricia Busto, Michelle Debatis, Ann Marshak-Rothstein

J Leukoc Biol. 2013 Nov; 94(5): 865–875. doi: 10.1189/jlb.0313126

PMCID:: PMC3800065

Abstract Article

Select item 364852719.

Cross Talk between Peritoneal Macrophages and B-1 Cells In Vitro

Felipe Garutti Thies, Maria Fernanda Lucatelli Laurindo, Elizabeth Cristina Perez, Ronni Romulo Novaes e Brito, Mario Mariano, Ana Flavia Popi

PLoS One. 2013; 8(5): e62805. Published online 2013 May 8. doi: 10.1371/journal.pone.0062805

PMCID:: PMC3648527

Abstract Article PDF–1.1M

Select item 359463820.

B1a cells enhance susceptibility to infection with virulent Francisella tularensis via modulation of NK/NKT cell responses

Deborah D. Crane, Amanda J. Griffin, Tara D. Wehrly, Catharine M. Bosio

J Immunol. Author manuscript; available in PMC 2014 Mar 15.

Published in final edited form as: J Immunol. 2013 Mar 15; 190(6): 2756–2766. Published online 2013 Feb 1. doi: 10.4049/jimmunol.1202697

PMCID:: PMC3594638

Abstract Article PDF–1.0M

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