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Select item 107302411.

Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction

Tamara P Martin, Eilidh A MacDonald, Ashley Bradley, Holly Watson, Priyanka Saxena, Eva A Rog-Zielinska, Anmar Raheem, Simon Fisher, Ali Ali Mohamed Elbassioni, Ohood Almuzaini, Catriona Booth, Morna Campbell, Alexandra Riddell, Pawel Herzyk, Karen Blyth, Colin Nixon, Lorena Zentilin, Colin Berry, Thomas Braun, Mauro Giacca, Martin W McBride, Stuart A Nicklin, Ewan R Cameron, Christopher M Loughrey

Cardiovasc Res. 2023 Nov; 119(16): 2663–2671. Published online 2023 Jul 11. doi: 10.1093/cvr/cvad107

PMCID:: PMC10730241

Abstract Article PDF–8.6M

Select item 107111912.

Runx1-R188Q germ line mutation induces inflammation and predisposition to hematologic malignancies in mice

Mohd Hafiz Ahmad, Mahesh Hegde, Waihay J. Wong, Mona Mohammadhosseini, Lisa Garrett, Anneliese Carrascoso, Neethu Issac, Benjamin Ebert, Jeffrey C. Silva, German Pihan, Lihua J. Zhu, Scot A. Wolfe, Anupriya Agarwal, P. Paul Liu, Lucio H. Castilla

Blood Adv. 2023 Dec 12; 7(23): 7304–7318. Published online 2023 Sep 28. doi: 10.1182/bloodadvances.2023010398

PMCID:: PMC10711191

Abstract Article PDF–3.1M

Select item 106241683.

RUNX1 facilitates heart failure progression through regulating TGF-β-induced cardiac remodeling

Peng Qi, Qian Zhai, Xiquan Zhang

PeerJ. 2023; 11: e16202. Published online 2023 Oct 31. doi: 10.7717/peerj.16202

PMCID:: PMC10624168

Abstract Article PDF–33M

Select item 102509264.

A critical role of RUNX1 in governing megakaryocyte-primed hematopoietic stem cell differentiation

Chen Wang, Zhaowei Tu, Xiongwei Cai, Weinan Wang, Ashely K. Davis, Kalpana Nattamai, Aditi Paranjpe, Philip Dexheimer, Jianqiang Wu, Frank Lei Huang, Hartmut Geiger, Gang Huang, Yi Zheng

Blood Adv. 2023 Jun 13; 7(11): 2590–2605. Published online 2023 Jan 23. doi: 10.1182/bloodadvances.2022008591

PMCID:: PMC10250926

Abstract Article PDF–7.9M

Select item 96972855.

Loss of Runx1 Induces Granulosa Cell Defects and Development of Ovarian Tumors in the Mouse

Kamiya Bridges, Humphrey H.-C. Yao, Barbara Nicol

Int J Mol Sci. 2022 Nov; 23(22): 14442. Published online 2022 Nov 21. doi: 10.3390/ijms232214442

PMCID:: PMC9697285

Abstract Article PDF–6.4M

Select item 93372736.

Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors

Martha Elena Díaz-Hernández, Christopher W Kinter, Shana R Watson, Giovanni Mella-Velazquez, Jarred Kaiser, Guanglu Liu, Nazir M Khan, Joseph L Roberts, Joseph Lorenzo, Hicham Drissi

Endocrinology. 2022 Sep; 163(9): bqac113. Published online 2022 Jul 26. doi: 10.1210/endocr/bqac113

PMCID:: PMC9337273

Abstract Article

Select item 90508247.

Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts

Shubham Dubey, Praveen K Dubey, Channakeshava Sokke Umeshappa, Yohannes T. Ghebre, Prasanna Krishnamurthy

J Cell Physiol. Author manuscript; available in PMC 2023 Apr 1.

Published in final edited form as: J Cell Physiol. 2022 Apr; 237(4): 2169–2182. Published online 2022 Jan 19. doi: 10.1002/jcp.30684

PMCID:: PMC9050824

Abstract Article PDF–2.6M

Select item 88557898.

Mosaic loss of chromosome Y promotes leukemogenesis and clonal hematopoiesis

Qi Zhang, Lei Zhao, Yi Yang, Shujun Li, Yu Liu, Chong Chen

JCI Insight. 2022 Feb 8; 7(3): e153768. Published online 2022 Feb 8. doi: 10.1172/jci.insight.153768

PMCID:: PMC8855789

Abstract Article PDF–5.3M

Select item 88287199.

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development

Dominic D. G. Owens, Giorgio Anselmi, A. Marieke Oudelaar, Damien J. Downes, Alessandro Cavallo, Joe R. Harman, Ron Schwessinger, Akin Bucakci, Lucas Greder, Sara de Ornellas, Danuta Jeziorska, Jelena Telenius, Jim R. Hughes, Marella F. T. R. de Bruijn

Nat Commun. 2022; 13: 773. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28376-8

PMCID:: PMC8828719

Abstract Article PDF–14M

Select item 867510710.

RUNX1 Regulates a Transcription Program That Affects the Dynamics of Cell Cycle Entry of Naive Resting B Cells

Inesa Thomsen, Natalia Kunowska, Roshni de Souza, Anne-Marie Moody, Greg Crawford, Yi-Fang Wang, Sanjay Khadayate, Chad Whilding, Jessica Strid, Mohammad M. Karimi, Alexis R. Barr, Niall Dillon, Pierangela Sabbattini

J Immunol. 2021 Dec 15; 207(12): 2976–2991. Published online 2021 Dec 15. doi: 10.4049/jimmunol.2001367

PMCID:: PMC8675107

Abstract Article PDF–2.9M

Select item 839515811.

Immunonano-Lipocarrier-Mediated Liver Sinusoidal Endothelial Cell-Specific RUNX1 Inhibition Impedes Immune Cell Infiltration and Hepatic Inflammation in Murine Model of NASH

Dinesh Mani Tripathi, Sumati Rohilla, Impreet Kaur, Hamda Siddiqui, Preety Rawal, Pinky Juneja, Vikash Kumar, Anupama Kumari, Vegi Ganga Modi Naidu, Seeram Ramakrishna, Subham Banerjee, Rekha Puria, Shiv K. Sarin, Savneet Kaur

Int J Mol Sci. 2021 Aug; 22(16): 8489. Published online 2021 Aug 6. doi: 10.3390/ijms22168489

PMCID:: PMC8395158

Abstract Article PDF–3.0M

Select item 821916212.

Runx1 shapes the chromatin landscape via a cascade of direct and indirect targets

Matthew R. Hass, Daniel Brissette, Sreeja Parameswaran, Mario Pujato, Omer Donmez, Leah C. Kottyan, Matthew T. Weirauch, Raphael Kopan

PLoS Genet. 2021 Jun; 17(6): e1009574. Published online 2021 Jun 10. doi: 10.1371/journal.pgen.1009574

PMCID:: PMC8219162

Abstract Article PDF–2.2M

Select item 790283313.

Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs

Hyojung Jeon, Keigo Asano, Arata Wakimoto, Kaushalya Kulathunga, Mai Thi Nhu Tran, Megumi Nakamura, Tomomasa Yokomizo, Michito Hamada, Satoru Takahashi

Sci Rep. 2021; 11: 4374. Published online 2021 Feb 23. doi: 10.1038/s41598-021-83652-9

PMCID:: PMC7902833

Abstract Article PDF–2.4M

Select item 745014314.

Jun Tang, Jing Xie, Wei Chen, Chenyi Tang, Jinjin Wu, Yiping Wang, Xue-Dong Zhou, Hou-De Zhou, Yi-Ping Li

J Biol Chem. 2020 Aug 14; 295(33): 11669–11681. Published online 2020 Jun 22. doi: 10.1074/jbc.RA119.007896

PMCID:: PMC7450143

Abstract Article PDF–6.9M

Select item 730833515.

Evidence for a role of RUNX1 as recombinase cofactor for TCRβ rearrangements and pathological deletions in ETV6-RUNX1 ALL

V. Seitz, K. Kleo, A. Dröge, S. Schaper, S. Elezkurtaj, N. Bedjaoui, L. Dimitrova, A. Sommerfeld, E. Berg, E. von der Wall, U. Müller, M. Joosten, D. Lenze, M. M. Heimesaat, C. Baldus, C. Zinser, A. Cieslak, E. Macintyre, C. Stocking, S. Hennig, M. Hummel

Sci Rep. 2020; 10: 10024. Published online 2020 Jun 22. doi: 10.1038/s41598-020-65744-0

PMCID:: PMC7308335

Abstract Article PDF–3.5M

Select item 652951916.

Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation

Fumiko Yano, Shinsuke Ohba, Yasutaka Murahashi, Sakae Tanaka, Taku Saito, Ung-il Chung

Sci Rep. 2019; 9: 7666. Published online 2019 May 21. doi: 10.1038/s41598-019-43948-3

PMCID:: PMC6529519

Abstract Article PDF–5.4M

Select item 620225617.

Runx1 role in epithelial and cancer cell proliferation implicates lipid metabolism and Scd1 and Soat1 activity

Prachi Jain, Mary Nattakom, David Holowka, Dong Hao Wang, J. Thomas Brenna, Amy Tsu Ku, Hoang Nguyen, Sheriff Ibrahim, Tudorita Tumbar

Stem Cells. Author manuscript; available in PMC 2019 Oct 1.

Published in final edited form as: Stem Cells. 2018 Oct; 36(10): 1603–1616. Published online 2018 Jul 29. doi: 10.1002/stem.2868

PMCID:: PMC6202256

Abstract Article PDF–2.3M

Select item 613594218.

Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach

Jordi Senserrich, Antoniana Batsivari, Stanislav Rybtsov, Sabrina Gordon-Keylock, Celine Souilhol, Frank Buchholz, David Hills, Suling Zhao, Alexander Medvinsky

Stem Cell Reports. 2018 Sep 11; 11(3): 784–794. Published online 2018 Sep 11. doi: 10.1016/j.stemcr.2018.08.004

PMCID:: PMC6135942

Abstract Article PDF–1.7M

Select item 605343819.

Runx1-Stat3 signaling regulates the epithelial stem cells in continuously growing incisors

Safiye E. Sarper, Toshihiro Inubushi, Hiroshi Kurosaka, Hitomi Ono Minagi, Koh-ichi Kuremoto, Takayoshi Sakai, Ichiro Taniuchi, Takashi Yamashiro

Sci Rep. 2018; 8: 10906. Published online 2018 Jul 19. doi: 10.1038/s41598-018-29317-6

PMCID:: PMC6053438

Abstract Article PDF–6.4M

Select item 586898820.

Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium

Michael Lie-A-Ling, Elli Marinopoulou, Andrew J. Lilly, Mairi Challinor, Rahima Patel, Christophe Lancrin, Valerie Kouskoff, Georges Lacaud

Development. 2018 Mar 1; 145(5): dev149419. doi: 10.1242/dev.149419

PMCID:: PMC5868988

Abstract Article

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