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Select item 101884841.

CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice

Hiroe Tetsu, Kanako Nakayama, Taku Nishijo, Takuo Yuki, Masaaki Miyazawa

Sci Rep. 2023; 13: 7936. Published online 2023 May 16. doi: 10.1038/s41598-023-35139-y

Correction in:: Sci Rep. 2023; 13: 10552.

PMCID:: PMC10188484

Abstract Article PDF–3.0M

Select item 75656852.

Antibody-Mediated Inhibition of CTLA4 Aggravates Atherosclerotic Plaque Inflammation and Progression in Hyperlipidemic Mice

Kikkie Poels, Mandy M. T. van Leent, Myrthe E. Reiche, Pascal J. H. Kusters, Stephan Huveneers, Menno P. J. de Winther, Willem J. M. Mulder, Esther Lutgens, Tom T. P. Seijkens

Cells. 2020 Sep; 9(9): 1987. Published online 2020 Aug 29. doi: 10.3390/cells9091987

PMCID:: PMC7565685

Abstract Article PDF–1.5M

Select item 69482723.

Preventive CTLA-4-Ig Treatment Reduces Hepatic Egg Load and Hepatic Fibrosis in Schistosoma mansoni-Infected Mice

Martina Sombetzki, Anne Rabes, Miriam Bischofsberger, Franziska Winkelmann, Nicole Koslowski, Cindy Schulz, Emil C. Reisinger

Biomed Res Int. 2019; 2019: 1704238. Published online 2019 Dec 16. doi: 10.1155/2019/1704238

PMCID:: PMC6948272

Abstract Article PDF–1.3M

Select item 67720424.

[Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti–CTLA-4 antibody in a mouse model

Tomomi Nakayama Iwata, Kiyoshi Sugihara, Teiji Wada, Toshinori Agatsuma

PLoS One. 2019; 14(10): e0222280. Published online 2019 Oct 1. doi: 10.1371/journal.pone.0222280

PMCID:: PMC6772042

Abstract Article PDF–1.6M

Select item 65428465.

CTLA-4 Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice

Hilman Zulkifli Amin, Naoto Sasaki, Tomoya Yamashita, Taiji Mizoguchi, Tomohiro Hayashi, Takuo Emoto, Takuya Matsumoto, Naofumi Yoshida, Tokiko Tabata, Sayo Horibe, Shoji Kawauchi, Yoshiyuki Rikitake, Ken-ichi Hirata

Sci Rep. 2019; 9: 8065. Published online 2019 May 30. doi: 10.1038/s41598-019-44523-6

PMCID:: PMC6542846

Abstract Article PDF–1.7M

Select item 64026116.

T regulatory cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells

Billur Akkaya, Yoshihiro Oya, Munir Akkaya, Jafar Al Souz, Amanda H. Holstein, Olena Kamenyeva, Juraj Kabat, Ryutaro Matsumura, David W. Dorward, Deborah D. Glass, Ethan M. Shevach

Nat Immunol. Author manuscript; available in PMC 2019 Jul 14.

Published in final edited form as: Nat Immunol. 2019 Feb; 20(2): 218–231. Published online 2019 Jan 14. doi: 10.1038/s41590-018-0280-2

PMCID:: PMC6402611

Abstract Article PDF–4.1M

Select item 59390417.

Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice

Xuexiang Du, Mingyue Liu, Juanjuan Su, Peng Zhang, Fei Tang, Peiying Ye, Martin Devenport, Xu Wang, Yan Zhang, Yang Liu, Pan Zheng

Cell Res. 2018 Apr; 28(4): 433–447. Published online 2018 Feb 20. doi: 10.1038/s41422-018-0012-z

PMCID:: PMC5939041

Abstract Article PDF–7.1M

Select item 56218988.

Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity

Pearl Bakhru, Meng-Lei Zhu, Hsing-Hui Wang, Lee K. Hong, Imran Khan, Maria Mouchess, Ajay S. Gulati, Joshua Starmer, Yafei Hou, David Sailer, Sandra Lee, Fengmin Zhao, John M. Kirkwood, Stergios Moschos, Lawrence Fong, Mark S. Anderson, Maureen A. Su

JCI Insight. 2017 Sep 21; 2(18): e93265. Published online 2017 Sep 21. doi: 10.1172/jci.insight.93265

PMCID:: PMC5621898

Abstract Article PDF–2.5M

Select item 48402279.

Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells

Susan P. Foy, Stefanie J. Mandl, Tracy dela Cruz, Joseph J. Cote, Evan J. Gordon, Erica Trent, Alain Delcayre, James Breitmeyer, Alex Franzusoff, Ryan B. Rountree

Cancer Immunol Immunother. 2016 May; 65(5): 537–549. Published online 2016 Mar 10. doi: 10.1007/s00262-016-1816-7

PMCID:: PMC4840227

Abstract Article PDF–1.2M

Select item 478071610.

Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner

Nobumasa Watanabe, Osamu Kaminuma, Noriko Kitamura, Takachika Hiroi

PLoS One. 2016; 11(3): e0150244. Published online 2016 Mar 7. doi: 10.1371/journal.pone.0150244

PMCID:: PMC4780716

Abstract Article PDF–3.1M

Select item 469396811.

A SNP in the immunoregulatory molecule CTLA-4 controls mRNA splicing in vivo but does not alter diabetes susceptibility in the NOD mouse

Fabian Jakubczik, Ken Jones, Jennifer Nichols, William Mansfield, Anne Cooke, Nick Holmes

Diabetes. Author manuscript; available in PMC 2016 Jul 1.

Published in final edited form as: Diabetes. 2016 Jan; 65(1): 120–128. Published online 2015 Oct 8. doi: 10.2337/db15-1175

PMCID:: PMC4693968

Abstract Article PDF–1.7M

Select item 420196312.

Opposing Effects of CTLA4 Insufficiency on Regulatory versus Conventional T Cells in Autoimmunity Converge on Effector Memory in Target Tissue

Priyadharshini Devarajan, Jason Miska, Jen Bon Lui, Dominika Swieboda, Zhibin Chen

J Immunol. Author manuscript; available in PMC 2015 Nov 1.

Published in final edited form as: J Immunol. 2014 Nov 1; 193(9): 4368–4380. Published online 2014 Sep 22. doi: 10.4049/jimmunol.1400876

PMCID:: PMC4201963

Abstract Article PDF–5.4M

Select item 407162413.

Candida-Elicited Murine Th17 Cells Express High CTLA-4 Compared to Th1 Cells and Are Resistant to Costimulation Blockade

Scott M. Krummey, Tamara L. Floyd, Danya Liu, Maylene E. Wagener, Mingqing Song, Mandy L. Ford

J Immunol. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: J Immunol. 2014 Mar 1; 192(5): 2495–2504. Published online 2014 Feb 3. doi: 10.4049/jimmunol.1301332

PMCID:: PMC4071624

Abstract Article PDF–4.5M

Select item 405143614.

Tyrosine 201 of the cytoplasmic tail of CTLA-4 critically affects T regulatory cell suppressive function

Melanie Stumpf, Xuyu Zhou, Shunsuke Chikuma, Jeffrey A. Bluestone

Eur J Immunol. Author manuscript; available in PMC 2015 Jun 1.

Published in final edited form as: Eur J Immunol. 2014 Jun; 44(6): 1737–1746. Published online 2014 Apr 15. doi: 10.1002/eji.201343891

PMCID:: PMC4051436

Abstract Article PDF–846K

Select item 357497415.

CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria

M J Barnes, T Griseri, A M F Johnson, W Young, F Powrie, A Izcue

Mucosal Immunol. 2013 Mar; 6(2): 324–334. Published online 2012 Aug 22. doi: 10.1038/mi.2012.75

PMCID:: PMC3574974

Abstract Article PDF–1.7M

Select item 354911816.

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire

Johan Verhagen, Raphaël Genolet, Graham J. Britton, Brian J. Stevenson, Catherine A. Sabatos-Peyton, Julian Dyson, Immanuel F. Luescher, David C. Wraith

Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3): E221–E230. Published online 2012 Dec 24. doi: 10.1073/pnas.1208573110

PMCID:: PMC3549118

Abstract Article PDF–1.4M

Select item 354708517.

Regulation of Cytotoxic T Lymphocyte Antigen 4 by Cyclic AMP

Jinghong Li, Ko-Wei Lin, Fiona Murray, Takeshi Nakajima, Yandong Zhao, David L. Perkins, Patricia W. Finn

Am J Respir Cell Mol Biol. 2013 Jan; 48(1): 63–70. doi: 10.1165/rcmb.2012-0155OC

PMCID:: PMC3547085

Abstract Article PDF–617K

Select item 338414518.

Release of dendritic cells from cognate CD4⁺ T-cell recognition results in impaired peripheral tolerance and fatal cytotoxic T-cell mediated autoimmunity

Sabine Muth, Kristian Schütze, Hansjörg Schild, Hans Christian Probst

Proc Natl Acad Sci U S A. 2012 Jun 5; 109(23): 9059–9064. Published online 2012 May 21. doi: 10.1073/pnas.1110620109

PMCID:: PMC3384145

Abstract Article PDF–1.0M

Select item 336960819.

Basis of CTLA-4 function in regulatory and conventional CD4⁺ T cells

Xuguang Tai, François Van Laethem, Leonid Pobezinsky, Terry Guinter, Susan O. Sharrow, Anthony Adams, Larry Granger, Michael Kruhlak, Tullia Lindsten, Craig B. Thompson, Lionel Feigenbaum, Alfred Singer

Blood. 2012 May 31; 119(22): 5155–5163. Prepublished online 2012 Mar 7. doi: 10.1182/blood-2011-11-388918