PMC Links for Gene (Select 124976) - PMC

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Items: 17

Select item 103301951.

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate

Hongwen Chen, Shahbaz Ahmed, Hongtu Zhao, Nadia Elghobashi-Meinhardt, Yaxin Dai, Jae Hun Kim, Jeffrey G McDonald, Xiaochun Li, Chia-Hsueh Lee

Cell. Author manuscript; available in PMC 2024 Jun 8.

Published in final edited form as: Cell. 2023 Jun 8; 186(12): 2644–2655.e16. Published online 2023 May 23. doi: 10.1016/j.cell.2023.04.028

PMCID:: PMC10330195

Abstract Article PDF–3.2M

Select item 79179062.

Prognostic Significance of Cytoplasmic SPNS2 Expression in Patients with Oral Squamous Cell Carcinoma

Jeng-Wei Lu, Yen-Shuo Tseng, Yu-Sheng Lo, Yueh-Min Lin, Chung-Min Yeh, Shu-Hui Lin

Medicina (Kaunas) 2021 Feb; 57(2): 164. Published online 2021 Feb 12. doi: 10.3390/medicina57020164

PMCID:: PMC7917906

Abstract Article PDF–1.3M

Select item 59837603.

Downregulation of the S1P Transporter Spinster Homology Protein 2 (Spns2) Exerts an Anti-Fibrotic and Anti-Inflammatory Effect in Human Renal Proximal Tubular Epithelial Cells

Olivier Blanchard, Bisera Stepanovska, Manuel Starck, Martin Erhardt, Isolde Römer, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter, Uwe Zangemeister-Wittke, Andrea Huwiler

Int J Mol Sci. 2018 May; 19(5): 1498. Published online 2018 May 17. doi: 10.3390/ijms19051498

PMCID:: PMC5983760

Abstract Article PDF–2.8M

Select item 56753034.

Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD

Hai B. Tran, Hubertus Jersmann, Tung Thanh Truong, Rhys Hamon, Eugene Roscioli, Miranda Ween, Melissa R. Pitman, Stuart M. Pitson, Greg Hodge, Paul N. Reynolds, Sandra Hodge

PLoS One. 2017; 12(11): e0179577. Published online 2017 Nov 7. doi: 10.1371/journal.pone.0179577

PMCID:: PMC5675303

Abstract Article PDF–15M

Select item 42037635.

Critical Role of Spns2, a Sphingosine-1-Phosphate Transporter, in Lung Cancer Cell Survival and Migration

Eric Bradley, Somsankar Dasgupta, Xue Jiang, Xiaying Zhao, Gu Zhu, Qian He, Michael Dinkins, Erhard Bieberich, Guanghu Wang

PLoS One. 2014; 9(10): e110119. Published online 2014 Oct 20. doi: 10.1371/journal.pone.0110119

PMCID:: PMC4203763

Abstract Article PDF–7.3M

Select item 103986626.

Enhancing Spns2/S1P in macrophages alleviates hyperinflammation and prevents immunosuppression in sepsis

Chao Fang, Pan Ren, Ganlan Bian, Jian Wang, Jiaxin Bai, Jiaxing Huang, Yixiao Ding, Xueyong Li, Mingkai Li, Zheng Hou

EMBO Rep. 2023 Aug; 24(8): e56635. Published online 2023 Jun 26. doi: 10.15252/embr.202256635

PMCID:: PMC10398662

Abstract Article PDF–3.1M

Select item 46530567.

Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases

Michael S. Donoviel, Nitai C. Hait, Subramaniam Ramachandran, Michael Maceyka, Kazuaki Takabe, Sheldon Milstien, Tamas Oravecz, Sarah Spiegel

FASEB J. 2015 Dec; 29(12): 5018–5028. Published online 2015 Aug 31. doi: 10.1096/fj.15-274936

PMCID:: PMC4653056

Abstract Article

Select item 49998258.

Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human

Masaya Sato, Hitoshi Ikeda, Baasanjav Uranbileg, Makoto Kurano, Daisuke Saigusa, Junken Aoki, Harufumi Maki, Hiroki Kudo, Kiyoshi Hasegawa, Norihiro Kokudo, Yutaka Yatomi

Sci Rep. 2016; 6: 32119. Published online 2016 Aug 26. doi: 10.1038/srep32119

PMCID:: PMC4999825

Abstract Article PDF–493K

Select item 51424609.

Hyperoxia-induced p47^phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P_1&2 signaling axis in lung endothelium

Anantha Harijith, Srikanth Pendyala, David L. Ebenezer, Alison W. Ha, Panfeng Fu, Yue-Ting Wang, Ke Ma, Peter T. Toth, Evgeny V. Berdyshev, Prasad Kanteti, Viswanathan Natarajan

Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1; 311(2): L337–L351. Published online 2016 Jun 24. doi: 10.1152/ajplung.00447.2015

PMCID:: PMC5142460

Abstract Article

Select item 357428810.

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network

Masayuki Nagahashi, Eugene Y. Kim, Akimitsu Yamada, Subramaniam Ramachandran, Jeremy C. Allegood, Nitai C. Hait, Michael Maceyka, Sheldon Milstien, Kazuaki Takabe, Sarah Spiegel

FASEB J. 2013 Mar; 27(3): 1001–1011. doi: 10.1096/fj.12-219618

PMCID:: PMC3574288

Abstract Article

Select item 421459811.

Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss

Jing Chen, Neil Ingham, John Kelly, Shalini Jadeja, David Goulding, Johanna Pass, Vinit B. Mahajan, Stephen H. Tsang, Anastasia Nijnik, Ian J. Jackson, Jacqueline K. White, Andrew Forge, Daniel Jagger, Karen P. Steel

PLoS Genet. 2014 Oct; 10(10): e1004688. Published online 2014 Oct 30. doi: 10.1371/journal.pgen.1004688

PMCID:: PMC4214598

Abstract Article PDF–3.2M

Select item 302347012.

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720

Yu Hisano久野悠, Naoki Kobayashi小林直木, Atsuo Kawahara川原敦雄, Akihito Yamaguchi山口明人, Tsuyoshi Nishi西毅

J Biol Chem. 2011 Jan 21; 286(3): 1758–1766. Published online 2010 Nov 17. doi: 10.1074/jbc.M110.171116

PMCID:: PMC3023470

Abstract Article PDF–2.8M

Select item 555356813.

A role for mitochondrial translation in promotion of viability in K-Ras mutant cells

Timothy D. Martin, Danielle R. Cook, Mei Yuk Choi, Mamie Z. Li, Kevin M. Haigis, Stephen J. Elledge

Cell Rep. Author manuscript; available in PMC 2017 Aug 11.

Published in final edited form as: Cell Rep. 2017 Jul 11; 20(2): 427–438. doi: 10.1016/j.celrep.2017.06.061

PMCID:: PMC5553568

Abstract Article PDF–1.8M

Select item 752370614.

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis

Katrin Tiemann, Carolina Garri, Sang Bok Lee, Paymaneh D. Malihi, Mincheol Park, Ruth M. Alvarez, Li Peng Yap, Parag Mallick, Jonathan E. Katz, Mitchell E. Gross, Kian Kani

Oncogene. Author manuscript; available in PMC 2020 Sep 29.

Published in final edited form as: Oncogene. 2019 Apr; 38(16): 3003–3018. Published online 2018 Dec 21. doi: 10.1038/s41388-018-0638-9