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Select item 111159581.

Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules

Christian Piehl, Jörg Piontek, Jimmi Cording, Hartwig Wolburg, Ingolf E. Blasig

Cell Mol Life Sci. 2010 Jun; 67(12): 2131–2140. Published online 2010 Mar 24. doi: 10.1007/s00018-010-0332-8

PMCID:: PMC11115958

Abstract Article PDF–701K

Select item 103933452.

Ultrasound-guided transfection of claudin-5 improves lung endothelial barrier function in lung injury without impairing innate immunity

Rajiv Sanwal, Victoria Mintsopoulos, Mihails Ditmans, Alice Lang, Elyse Latreille, Siavash Ghaffari, Negar Khosraviani, Raffi Karshafian, Howard Leong-Poi, David M. Hwang, Laurent Brochard, Alberto Goffi, Arthur S. Slutsky, Warren L. Lee

Am J Physiol Lung Cell Mol Physiol. 2023 Aug 1; 325(2): L135–L142. Published online 2023 Jun 13. doi: 10.1152/ajplung.00107.2023

PMCID:: PMC10393345

Abstract Article

Select item 90852353.

Claudin-5 relieves cognitive decline in Alzheimer’s disease mice through suppression of inhibitory GABAergic neurotransmission

Ning Zhu, Meidan Wei, Linguang Yuan, Xiaodan He, Chunli Chen, Aimin Ji, Guozeng Zhang

Aging (Albany NY) 2022 Apr 30; 14(8): 3554–3568. Published online 2022 Apr 26. doi: 10.18632/aging.204029

PMCID:: PMC9085235

Abstract Article PDF–5.9M

Select item 90104154.

Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Chris Greene, Nicole Hanley, Cristina R. Reschke, Avril Reddy, Maarja A. Mäe, Ruairi Connolly, Claire Behan, Eoin O’Keeffe, Isobel Bolger, Natalie Hudson, Conor Delaney, Michael A. Farrell, Donncha F. O’Brien, Jane Cryan, Francesca M. Brett, Alan Beausang, Christer Betsholtz, David C. Henshall, Colin P. Doherty, Matthew Campbell

Nat Commun. 2022; 13: 2003. Published online 2022 Apr 14. doi: 10.1038/s41467-022-29657-y

PMCID:: PMC9010415

Abstract Article PDF–4.5M

Select item 86910425.

Appearance of claudin-5⁺ leukocyte subtypes in the blood and CNS during progression of EAE

Dylan Krajewski, Debayon Paul, Shujun Ge, Evan Jellison, Joel S. Pachter

J Neuroinflammation. 2021; 18: 296. Published online 2021 Dec 21. doi: 10.1186/s12974-021-02328-3

PMCID:: PMC8691042

Abstract Article PDF–4.6M

Select item 79360666.

Selective expression of claudin-5 in thymic endothelial cells regulates the blood–thymus barrier and T-cell export

Takahiro Nagatake, Yan-Chun Zhao, Takeshi Ito, Masahiko Itoh, Kohei Kometani, Mikio Furuse, Azusa Saika, Eri Node, Jun Kunisawa, Nagahiro Minato, Yoko Hamazaki

Int Immunol. 2021 Mar; 33(3): 171–182. Published online 2020 Oct 10. doi: 10.1093/intimm/dxaa069

PMCID:: PMC7936066

Abstract Article PDF–1.6M

Select item 51126957.

Appearance of claudin-5⁺ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

Debayon Paul, Valentina Baena, Shujun Ge, Xi Jiang, Evan R. Jellison, Timothy Kiprono, Dritan Agalliu, Joel S. Pachter

J Neuroinflammation. 2016; 13: 292. Published online 2016 Nov 16. doi: 10.1186/s12974-016-0755-8

PMCID:: PMC5112695

Abstract Article PDF–2.4M

Select item 42445838.

Biphasic Modulation of Paracellular Claudin-5 Expression in Mouse Brain Endothelial Cells Is Mediated through the Phosphoinositide-3-Kinase/AKT Pathway

Ryan B. Camire, Holly J. Beaulac, Stephanie A. Brule, Annie I. McGregor, Emily E. Lauria, Colin L. Willis

J Pharmacol Exp Ther. 2014 Dec; 351(3): 654–662. Published online 2014 Dec. doi: 10.1124/jpet.114.218339

PMCID:: PMC4244583

Abstract Article PDF–1.8M

Select item 100448259.

The CLDN5 gene at the blood-brain barrier in health and disease

Yosuke Hashimoto, Chris Greene, Arnold Munnich, Matthew Campbell

Fluids Barriers CNS. 2023; 20: 22. Published online 2023 Mar 28. doi: 10.1186/s12987-023-00424-5

PMCID:: PMC10044825

Abstract Article PDF–6.7M

Select item 934885010.

Claudin5 protects the peripheral endothelial barrier in an organ and vessel-type-specific manner

Mark Richards, Emmanuel Nwadozi, Sagnik Pal, Pernilla Martinsson, Mika Kaakinen, Marleen Gloger, Elin Sjöberg, Katarzyna Koltowska, Christer Betsholtz, Lauri Eklund, Sofia Nordling, Lena Claesson-Welsh

eLife. 2022; 11: e78517. Published online 2022 Jul 21. doi: 10.7554/eLife.78517

PMCID:: PMC9348850

Abstract Article PDF–14M

Select item 926281511.

Vitamin D Receptor Upregulates Tight Junction Protein Claudin-5 against Colitis-Associated Tumorigenesis

Yongguo Zhang, Shari Garrett, Robert E. Carroll, Yinglin Xia, Jun Sun

Mucosal Immunol. Author manuscript; available in PMC 2022 Sep 25.

Published in final edited form as: Mucosal Immunol. 2022 Apr; 15(4): 683–697. Published online 2022 Mar 25. doi: 10.1038/s41385-022-00502-1

PMCID:: PMC9262815

Abstract Article PDF–1.4M

Select item 835887112.

Super‐resolved local recruitment of CLDN5 to filtration slits implicates a direct relationship with podocyte foot process effacement

Florian Tesch, Florian Siegerist, Eleonora Hay, Nadine Artelt, Christoph Daniel, Kerstin Amann, Uwe Zimmermann, Panagiotis Kavvadas, Olaf Grisk, Christos Chadjichristos, Karlhans Endlich, Christos Chatziantoniou, Nicole Endlich

J Cell Mol Med. 2021 Aug; 25(16): 7631–7641. Published online 2021 Jun 22. doi: 10.1111/jcmm.16519

PMCID:: PMC8358871

Abstract Article PDF–2.0M

Select item 719063613.

Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles

Slava Rom, Nathan A. Heldt, Sachin Gajghate, Alecia Seliga, Nancy L. Reichenbach, Yuri Persidsky

Sci Rep. 2020; 10: 7274. Published online 2020 Apr 29. doi: 10.1038/s41598-020-64349-x

Correction in:: Sci Rep. 2020; 10: 18828.

PMCID:: PMC7190636

Abstract Article PDF–4.3M

Select item 669383414.

Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy

Natalie Hudson, Lucia Celkova, Alan Hopkins, Chris Greene, Federica Storti, Ema Ozaki, Erin Fahey, Sofia Theodoropoulou, Paul F. Kenna, Marian M. Humphries, Annie M. Curtis, Eleanor Demmons, Akeem Browne, Shervin Liddie, Matthew S. Lawrence, Christian Grimm, Mark T. Cahill, Pete Humphries, Sarah L. Doyle, Matthew Campbell

JCI Insight. 2019 Aug 8; 4(15): e130273. Published online 2019 Aug 8. doi: 10.1172/jci.insight.130273

PMCID:: PMC6693834

Abstract Article PDF–43M

Select item 527050815.

Nitric Oxide Interacts with Caveolin-1 to Facilitate Autophagy-Lysosome-Mediated Claudin-5 Degradation in Oxygen-Glucose Deprivation-Treated Endothelial Cells

Jie Liu, John Weaver, Xinchun Jin, Yuan Zhang, Ji Xu, Ke J. Liu, Weiping Li, Wenlan Liu

Mol Neurobiol. Author manuscript; available in PMC 2017 Jan 27.

Published in final edited form as: Mol Neurobiol. 2016 Nov; 53(9): 5935–5947. Published online 2015 Oct 29. doi: 10.1007/s12035-015-9504-8

PMCID:: PMC5270508

Abstract Article PDF–3.3M

Select item 464027716.

Expression of the ALS-causing variant hSOD1^G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood–spinal cord barrier model

Sabrina Meister, Steffen E Storck, Erik Hameister, Christian Behl, Sascha Weggen, Albrecht M Clement, Claus U Pietrzik

J Cereb Blood Flow Metab. 2015 Jul; 35(7): 1112–1121. Published online 2015 Apr 8. doi: 10.1038/jcbfm.2015.57

PMCID:: PMC4640277

Abstract Article PDF–662K

Select item 427356017.

Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury

Nikola Sladojevic, Svetlana M. Stamatovic, Richard F. Keep, Jamison J. Grailer, J. Vidya Sarma, Peter A. Ward, Anuska V. Andjelkovic

Neurobiol Dis. Author manuscript; available in PMC 2015 Jul 1.

Published in final edited form as: Neurobiol Dis. 2014 Jul; 67: 57–70. Published online 2014 Mar 21. doi: 10.1016/j.nbd.2014.03.010

PMCID:: PMC4273560

Abstract Article PDF–1.0M

Select item 401616918.

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

Daniel Knowland, Ahmet Arac, Kohei Sekiguchi, Martin Hsu, Sarah E. Lutz, John Perrino, Gary K. Steinberg, Ben A. Barres, Axel Nimmerjahn, Dritan Agalliu

Neuron. Author manuscript; available in PMC 2015 May 7.

Published in final edited form as: Neuron. 2014 May 7; 82(3): 603–617. Published online 2014 Apr 17. doi: 10.1016/j.neuron.2014.03.003

PMCID:: PMC4016169

Abstract Article PDF–4.1M

Select item 393094619.

Role of Claudin-5 in the Attenuation of Murine Acute Lung Injury by Simvastatin

Weiguo Chen, Rajesh Sharma, Alicia N. Rizzo, Jessica H. Siegler, Joe G. N. Garcia, Jeffrey R. Jacobson

Am J Respir Cell Mol Biol. 2014 Feb; 50(2): 328–336. doi: 10.1165/rcmb.2013-0058OC

PMCID:: PMC3930946

Abstract Article PDF–1.3M

Select item 309592120.

Endothelial Dysfunction and Claudin 5 Regulation during Acrolein-Induced Lung Injury

An Soo Jang, Vincent J. Concel, Kiflai Bein, Kelly A. Brant, Shannen Liu, Hannah Pope-Varsalona, Richard A. Dopico, Jr., Y. P. Peter Di, Daren L. Knoell, Aaron Barchowsky, George D. Leikauf

Am J Respir Cell Mol Biol. 2011 Apr; 44(4): 483–490. Published online 2010 Jun 4. doi: 10.1165/rcmb.2009-0391OC