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Select item 67589231.

Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model

Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Eric H. Chang, Anil K. Malhotra, Peter Davies

J Neurochem. Author manuscript; available in PMC 2019 Sep 24.

Published in final edited form as: J Neurochem. 2019 Jan; 148(1): 127–135. Published online 2018 Nov 12. doi: 10.1111/jnc.14593

PMCID:: PMC6758923

Abstract Article PDF–826K

Select item 66726782.

Site-Specific Role of Catechol-O-Methyltransferase in Dopamine Overflow within Prefrontal Cortex and Dorsal Striatum

Leonid Yavich, Markus M. Forsberg, Maria Karayiorgou, Joseph A. Gogos, Pekka T. Männistö

J Neurosci. 2007 Sep 19; 27(38): 10196–10209. doi: 10.1523/JNEUROSCI.0665-07.2007

PMCID:: PMC6672678

Abstract Article PDF–300K

Select item 65340653.

Heritable Differences in Catecholamine Signaling Modulate Susceptibility to Trauma and Response to Methylphenidate Treatment: Relevance for PTSD

Jessica Deslauriers, Mate Toth, Xianjin Zhou, Victoria B. Risbrough

Front Behav Neurosci. 2019; 13: 111. Published online 2019 May 17. doi: 10.3389/fnbeh.2019.00111

PMCID:: PMC6534065

Abstract Article PDF–2.0M

Select item 55845234.

Adolescence is the starting point of sex-dichotomous COMT genetic effects

S Sannino, M C Padula, F Managò, M Schaer, M Schneider, M Armando, E Scariati, F Sloan-Bena, M Mereu, M Pontillo, S Vicari, G Contarini, C Chiabrera, M Pagani, A Gozzi, S Eliez, F Papaleo

Transl Psychiatry. 2017 May; 7(5): e1141. Published online 2017 May 30. doi: 10.1038/tp.2017.109

PMCID:: PMC5584523

Abstract Article PDF–1.5M

Select item 55541805.

Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice

Megumi Kanasaki, Swayam Prakash Srivastava, Fan Yang, Ling Xu, Sumiyo Kudoh, Munehiro Kitada, Norikazu Ueki, Hyoh Kim, Jinpeng Li, Satoru Takeda, Keizo Kanasaki, Daisuke Koya

Sci Rep. 2017; 7: 7927. Published online 2017 Aug 11. doi: 10.1038/s41598-017-08513-w

PMCID:: PMC5554180

Abstract Article PDF–4.5M

Select item 40598906.

Generation and Characterization of Humanized Mice Carrying COMT158 Met/Val Alleles

Victoria Risbrough, Baohu Ji, Richard Hauger, Xianjin Zhou

Neuropsychopharmacology. 2014 Jul; 39(8): 1823–1832. Prepublished online 2014 Feb 10. Published online 2014 Mar 26. doi: 10.1038/npp.2014.29

PMCID:: PMC4059890

Abstract Article PDF–591K

Select item 40071097.

Catechol-O-Methyltransferase and 3,4-(±)-Methylenedioxymethamphetamine Toxicity

Joseph M. Herndon, Aram B. Cholanians, Lucina E. Lizarraga, Serrine S. Lau, Terrence J. Monks

Toxicol Sci. 2014 May 1; 139(1): 162–173. Published online 2014 Feb 12. doi: 10.1093/toxsci/kfu035

PMCID:: PMC4007109

Abstract Article PDF–2.6M

Select item 39665428.

Genetic variation in COMT activity impacts learning and dopamine release capacity in the striatum

Eleanor H. Simpson, Julia Morud, Vanessa Winiger, Dominik Biezonski, Judy P. Zhu, Mary Elizabeth Bach, Gael Malleret, H. Jonathan Polan, Scott Ng-Evans, Paul E.M. Phillips, Christoph Kellendonk, Eric R. Kandel

Learn Mem. 2014 Apr; 21(4): 205–214. Published online 2014 Apr. doi: 10.1101/lm.032094.113

PMCID:: PMC3966542

Abstract Article PDF–651K

Select item 35238439.

Effects of sex and COMT genotype on environmentally modulated cognitive control in mice

Francesco Papaleo, Lucy Erickson, Guangping Liu, Jingshan Chen, Daniel R. Weinberger

Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49): 20160–20165. Published online 2012 Nov 19. doi: 10.1073/pnas.1214397109

PMCID:: PMC3523843

Abstract Article PDF–679K

Select item 349566810.

Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity

Douglas Tsao, Jeffrey S Wieskopf, Naim Rashid, Robert E Sorge, Rachel L Redler, Samantha K Segall, Jeffrey S Mogil, William Maixner, Nikolay V Dokholyan, Luda Diatchenko

Mol Pain. 2012; 8: 25. Published online 2012 Apr 13. doi: 10.1186/1744-8069-8-25

PMCID:: PMC3495668

Abstract Article PDF–1.9M

Select item 305531511.

Chronic Adolescent Exposure to Δ-9-Tetrahydrocannabinol in COMT Mutant Mice: Impact on Psychosis-Related and Other Phenotypes

Colm MP O'Tuathaigh, Magdalena Hryniewiecka, Aine Behan, Orna Tighe, Catherine Coughlan, Lieve Desbonnet, Mary Cannon, Maria Karayiorgou, Joseph A Gogos, David R Cotter, John L Waddington

Neuropsychopharmacology. 2010 Oct; 35(11): 2262–2273. Published online 2010 Jul 14. doi: 10.1038/npp.2010.100

PMCID:: PMC3055315

Abstract Article PDF–608K

Select item 303756312.

A B2 SINE insertion in the Comt1 gene (Comt1^B2i) results in an overexpressing, behavior modifying allele present in classical inbred mouse strains

R L Kember, C Fernandes, E M Tunbridge, L Liu, J L Payá-Cano, M J Parsons, L C Schalkwyk

Genes Brain Behav. 2010 Nov; 9(8): 925–932. doi: 10.1111/j.1601-183X.2010.00614.x

PMCID:: PMC3037563

Abstract Article PDF–1.2M

Select item 297580513.

Comt1 Genotype and Expression Predicts Anxiety and Nociceptive Sensitivity in Inbred Strains of Mice

SK Segall, AG Nackley, L Diatchenko, WR Lariviere, X Lu, JS Marron, L Grabowski-Boase, JR Walker, G Slade, J Gauthier, JS Bailey, BM Steffy, TM Maynard, LM Tarantino, T Wiltshire

Genes Brain Behav. Author manuscript; available in PMC 2011 Nov 1.

Published in final edited form as: Genes Brain Behav. 2010 Nov; 9(8): 933–946. doi: 10.1111/j.1601-183X.2010.00633.x

PMCID:: PMC2975805

Abstract Article PDF–766K

Select item 295803814.

Murine Warriors or Worriers: The Saga of Comt1, B2 SINE Elements, and the Future of Translational Genetics

Abraham A. Palmer, Stephanie C. Dulawa

Front Neurosci. 2010; 4: 177. Published online 2010 Oct 8. doi: 10.3389/fnins.2010.00177

PMCID:: PMC2958038

Article PDF–190K

Select item 280807815.

Preeclampsia : 2-Methoxyestradiol Induces Cytotrophoblast Invasion and Vascular Development Specifically under Hypoxic Conditions

Soo Bong Lee, Amy P. Wong, Keizo Kanasaki, Yong Xu, Vivek K. Shenoy, Thomas F. McElrath, George M. Whitesides, Raghu Kalluri

Am J Pathol. 2010 Feb; 176(2): 710–720. doi: 10.2353/ajpath.2010.090513

PMCID:: PMC2808078

Abstract Article PDF–1.7M

Select item 278252216.

Intrarenal Dopamine Attenuates DOCA/HS-Induced Blood Pressure Elevation in Part through Activation of a Medullary COX-2 Pathway

Bing Yao, Raymond C. Harris, Ming-Zhi Zhang

Hypertension. Author manuscript; available in PMC 2010 Nov 1.

Published in final edited form as: Hypertension. 2009 Nov; 54(5): 1077–1083. Published online 2009 Sep 21. doi: 10.1161/HYPERTENSIONAHA.109.137174

PMCID:: PMC2782522

Abstract Article PDF–1.5M

Select item 12209617.

Reduced natriuretic response to acute sodium loading in COMT Gene deleted mice

Cecilia Odlind, Ilkka Reenilä, Pekka T Männistö, Risto Juvonen, Staffan Uhlén, Joseph A Gogos, Maria Karayiorgou, Peter Hansell

BMC Physiol. 2002; 2: 14. Published online 2002 Aug 21. doi: 10.1186/1472-6793-2-14

PMCID:: PMC122096

Abstract Article PDF–311K

Select item 880462318.

The impact of pimavanserin on psychotic phenotypes and tau phosphorylation in the P301L/COMT– and rTg(P301L)4510 mouse models of Alzheimer's disease

Heidy Jimenez, Leslie Adrien, Adam Wolin, John Eun, Eric H. Chang, Ethan S. Burstein, Jesus Gomar, Peter Davies, Jeremy Koppel

Alzheimers Dement (N Y) 2022; 8(1): e12247. Published online 2022 Feb 1. doi: 10.1002/trc2.12247

PMCID:: PMC8804623

Abstract Article PDF–913K

Select item 620538919.

Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice

Jacqueline G. Parchem, Keizo Kanasaki, Megumi Kanasaki, Hikaru Sugimoto, Liang Xie, Yuki Hamano, Soo Bong Lee, Vincent H. Gattone, Samuel Parry, Jerome F. Strauss, Vesna D. Garovic, Thomas F. McElrath, Karen H. Lu, Baha M. Sibai, Valerie S. LeBleu, Peter Carmeliet, Raghu Kalluri

J Clin Invest. 2018 Nov 1; 128(11): 5008–5017. Published online 2018 Oct 8. doi: 10.1172/JCI99026