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Select item 110684121.

Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at Cyp1a1 upon exposure later in life

Chinonye Doris Onuzulu, Samantha Lee, Sujata Basu, Jeannette Comte, Yan Hai, Nikho Hizon, Shivam Chadha, Maria Shenna Fauni, Shana Kahnamoui, Bo Xiang, Andrew J. Halayko, Vernon W. Dolinsky, Christopher D. Pascoe, Meaghan J. Jones

Am J Physiol Lung Cell Mol Physiol. 2023 Nov 1; 325(5): L552–L567. Published online 2023 Aug 29. doi: 10.1152/ajplung.00192.2023

PMCID:: PMC11068412

Abstract Article

Select item 108187462.

Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity

Ruoyue Huang, Jingyi Duan, Wen Huang, Yan Cheng, Beiwei Zhu, Fei Li

Toxins (Basel) 2024 Jan; 16(1): 35. Published online 2024 Jan 9. doi: 10.3390/toxins16010035

PMCID:: PMC10818746

Abstract Article PDF–5.8M

Select item 94934743.

Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis

Sweta Ghosh, Bhagavatula Moorthy, Bodduluri Haribabu, Venkatakrishna Rao Jala

Front Immunol. 2022; 13: 1004603. Published online 2022 Sep 8. doi: 10.3389/fimmu.2022.1004603

PMCID:: PMC9493474

Abstract Article PDF–18M

Select item 76097874.

Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation

Li‐xing Tian, Xin Tang, Wei Ma, Jing Wang, Wei Zhang, Kuan Liu, Tao Chen, Jun‐yu Zhu, Hua‐ping Liang

FEBS Open Bio. 2020 Nov; 10(11): 2316–2328. Published online 2020 Sep 23. doi: 10.1002/2211-5463.12977

PMCID:: PMC7609787

Abstract Article PDF–6.8M

Select item 59195535.

Aberrant CYP1A1 Induction: Discrepancy of CYP1A1 mRNA and Aryl Hydrocarbon Hydroxylase Activity in Mutant Cells of Mouse Hepatoma Line, Hepa‐1

Hideaki Kikuchi, Masahiro Usuda, Ikuko Sagami, Shuntaro Ikawa, Minro Watanabe

Jpn J Cancer Res. 1994 Jul; 85(7): 710–717. doi: 10.1111/j.1349-7006.1994.tb02419.x

PMCID:: PMC5919553

Summary PDF–493K

Select item 58374546.

Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal β-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants

Paramahamsa Maturu, Yanhong Wei-Liang, Weiwu Jiang, Lihua Wang, Krithika Lingappan, Roberto Barrios, Yao Liang, Bhagavatula Moorthy, Xanthi I. Couroucli

Toxicol Sci. 2017 May; 157(1): 260–271. Published online 2017 Feb 13. doi: 10.1093/toxsci/kfx036

Correction in:: Toxicol Sci. 2022 May; 187(1): 187.

PMCID:: PMC5837454

Abstract Article PDF–1.7M

Select item 54286987.

Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome

Krithika Lingappan, Suman Maity, Weiwu Jiang, Lihua Wang, Xanthi Couroucli, Alex Veith, Guodong Zhou, Cristian Coarfa, Bhagavatula Moorthy

Sci Rep. 2017; 7: 642. Published online 2017 Apr 4. doi: 10.1038/s41598-017-00516-x

PMCID:: PMC5428698

Abstract Article PDF–4.5M

Select item 42445798.

Role of CYP1A1 in Modulating the Vascular and Blood Pressure Benefits of Omega-3 Polyunsaturated Fatty Acids

Larry N. Agbor, Elani F. Wiest, Michael Rothe, Wolf-Hagen Schunck, Mary K. Walker

J Pharmacol Exp Ther. 2014 Dec; 351(3): 688–698. Published online 2014 Dec. doi: 10.1124/jpet.114.219535

PMCID:: PMC4244579

Abstract Article PDF–1.5M

Select item 35912359.

Harmine and Harmaline Downregulate TCDD-Induced Cyp1a1 in the Livers and Lungs of C57BL/6 Mice

Mohamed A. M. El Gendy, Ayman O. S. El-Kadi

Biomed Res Int. 2013; 2013: 258095. Published online 2012 Dec 20. doi: 10.1155/2013/258095

PMCID:: PMC3591235

Abstract Article PDF–890K

Select item 349448310.

Elevated blood pressure in cytochrome P4501A1 knockout mice is associated with reduced vasodilation to omega-3 polyunsaturated fatty acids

Larry N. Agbor, Mary T. Walsh, Jason R. Boberg, Mary K. Walker

Toxicol Appl Pharmacol. Author manuscript; available in PMC 2013 Nov 1.

Published in final edited form as: Toxicol Appl Pharmacol. 2012 Nov 1; 264(3): 351–360. Published online 2012 Sep 18. doi: 10.1016/j.taap.2012.09.007

PMCID:: PMC3494483

Abstract Article PDF–1.8M

Select item 291205511.

Organ-Specific Roles of CYP1A1 during Detoxication of Dietary Benzo[a]pyrene

Zhanquan Shi, Nadine Dragin, Marina Gálvez-Peralta, Lucia F. Jorge-Nebert, Marian L. Miller, Bin Wang, Daniel W. Nebert

Mol Pharmacol. 2010 Jul; 78(1): 46–57. doi: 10.1124/mol.110.063438

PMCID:: PMC2912055

Abstract Article PDF–1.9M

Select item 268490812.

Knock-In Mouse Lines Expressing either Mitochondrial or Microsomal CYP1A1: Differing Responses to Dietary Benzo[a]pyrene as Proof of Principle

Hongbin Dong, Timothy P. Dalton, Marian L. Miller, Ying Chen, Shigeyuki Uno, Zhanquan Shi, Howard G. Shertzer, Seema Bansal, Narayan G. Avadhani, Daniel W. Nebert

Mol Pharmacol. 2009 Mar; 75(3): 555–567. Published online 2008 Dec 1. doi: 10.1124/mol.108.051888

Correction in:: Mol Pharmacol. 2009 Aug; 76(2): 452.

PMCID:: PMC2684908

Abstract Article PDF–536K

Select item 55357813.

Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast.

S Kimura, H H Smith, O Hankinson, D W Nebert

EMBO J. 1987 Jul; 6(7): 1929–1933. doi: 10.1002/j.1460-2075.1987.tb02453.x

PMCID:: PMC553578

Summary Page Browse PDF–1.0M

Select item 4051614.

Cytochrome P450 1A1 promoter as a genetic switch for the regulatable and physiological expression of a plasma protein in transgenic mice.

J D Smith, E Wong, M Ginsberg

Proc Natl Acad Sci U S A. 1995 Dec 5; 92(25): 11926–11930. doi: 10.1073/pnas.92.25.11926

PMCID:: PMC40516

Summary Page Browse PDF–1.1M

Select item 872869115.

Molecular Mechanisms of Pulmonary Carcinogenesis by Polycyclic Aromatic Hydrocarbons (PAHs): Implications for Human Lung Cancer

Rachel Stading, Grady Gastelum, Chun Chu, Weiwu Jiang, Bhagavatula Moorthy

Semin Cancer Biol. Author manuscript; available in PMC 2022 Jan 5.

Published in final edited form as: Semin Cancer Biol. 2021 Nov; 76: 3–16. Published online 2021 Jul 7. doi: 10.1016/j.semcancer.2021.07.001

PMCID:: PMC8728691

Abstract Article PDF–1.9M

Select item 857904116.

Streptococcus gallolyticus Increases Expression and Activity of Aryl Hydrocarbon Receptor-Dependent CYP1 Biotransformation Capacity in Colorectal Epithelial Cells

Rahwa Taddese, Rian Roelofs, Derk Draper, Xinqun Wu, Shaoguang Wu, Dorine W. Swinkels, Harold Tjalsma, Annemarie Boleij

Front Cell Infect Microbiol. 2021; 11: 740704. Published online 2021 Oct 27. doi: 10.3389/fcimb.2021.740704

PMCID:: PMC8579041

Abstract Article PDF–1.7M

Select item 815291717.

CYP1A1 Enzymatic Activity Influences Skin Inflammation Via Regulation of the AHR Pathway

Mariela Kyoreva, Ying Li, Mariyah Hoosenally, Jonathan Hardman-Smart, Kirsten Morrison, Isabella Tosi, Mauro Tolaini, Guillermo Barinaga, Brigitta Stockinger, Ulrich Mrowietz, Frank O. Nestle, Catherine H. Smith, Jonathan N. Barker, Paola Di Meglio

J Invest Dermatol. 2021 Jun; 141(6): 1553–1563.e3. doi: 10.1016/j.jid.2020.11.024