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Select item 110463971.

Myeloid Hif2α is not essential to maintain systemic iron homeostasis.

Chesta Jain, Sanjana Parmini, Wesley Huang, Sean Hannifin, Rashi Singhal, Nupur K. Das, Kyoung Eun Lee, Yatrik M. Shah

Exp Hematol. Author manuscript; available in PMC 2024 Apr 26.

Published in final edited form as: Exp Hematol. 2023 Sep-Oct; 125-126: 25–36.e1. Published online 2023 Aug 8. doi: 10.1016/j.exphem.2023.08.001

PMCID:: PMC11046397

Abstract Article PDF–1.1M

Select item 110215632.

EPAS1 expression contributes to maintenance of the primordial follicle pool in the mouse ovary

Jacinta H. Martin, Ilana R. Bernstein, Jess M. Lyons, Ariel R. Brady, Nishani S. Mabotuwana, Simone J. Stanger, Camila Salum De Oliveira, Katerina B. Damyanova, Brett Nixon, Tessa Lord

Sci Rep. 2024; 14: 8770. Published online 2024 Apr 16. doi: 10.1038/s41598-024-59382-z

PMCID:: PMC11021563

Abstract Article PDF–7.9M

Select item 109952613.

Chronic hypoxia impairs skeletal muscle repair via HIF‐2α stabilization

Amelia Yin, Wenyan Fu, Anthony Elengickal, Joonhee Kim, Yang Liu, Anne Bigot, Kamal Mamchaoui, Jarrod A. Call, Hang Yin

J Cachexia Sarcopenia Muscle. 2024 Apr; 15(2): 631–645. Published online 2024 Feb 9. doi: 10.1002/jcsm.13436

PMCID:: PMC10995261

Abstract Article PDF–6.9M

Select item 109665664.

Activation of Intestinal HIF2α Ameliorates Iron‐Refractory Anemia

Yingying Yu, Yunxing Su, Sisi Yang, Yutong Liu, Zhiting Lin, Nupur K. Das, Qian Wu, Jiahui Zhou, Shumin Sun, Xiaopeng Li, Wuyang Yue, Yatrik M. Shah, Junxia Min, Fudi Wang

Adv Sci (Weinh) 2024 Mar; 11(12): 2307022. Published online 2024 Jan 20. doi: 10.1002/advs.202307022

PMCID:: PMC10966566

Abstract Article PDF–7.8M

Select item 109530785.

PDGFRβ + cell HIF2α is dispensable for white adipose tissue metabolic remodeling and hepatic lipid accumulation in obese mice

Tao Yao, Danni Wei, Xin Tian, Lin Zhao, Qiangyou Wan, Xiaoli Zhang, Juan Cai, Siqi Li, Bowen Diao, Suihan Feng, Bo Shan, Mengle Shao, Ying Wu

Lipids Health Dis. 2024; 23: 81. Published online 2024 Mar 20. doi: 10.1186/s12944-024-02069-1

PMCID:: PMC10953078

Abstract Article PDF–2.7M

Select item 100683446.

Effects of long-term tubular HIF-2α overexpression on progressive renal fibrosis in a chronic kidney disease model

Dal-Ah Kim, Mi-Ran Lee, Hyung Jung Oh, Myong Kim, Kyoung Hye Kong

BMB Rep. 2023 Mar 31; 56(3): 196–201. Published online 2023 Jan 31. doi: 10.5483/BMBRep.2022-0145

PMCID:: PMC10068344

Abstract Article PDF–5.6M

Select item 97720607.

Conditional deletion of HIF-2α in mouse nucleus pulposus reduces fibrosis and provides mild and transient protection from age-dependent structural changes in intervertebral disc

Shira N. Johnston, Vedavathi Madhu, Irving M. Shapiro, Makarand V. Risbud

J Bone Miner Res. Author manuscript; available in PMC 2023 Dec 1.

Published in final edited form as: J Bone Miner Res. 2022 Dec; 37(12): 2512–2530. Published online 2022 Oct 12. doi: 10.1002/jbmr.4707

PMCID:: PMC9772060

Abstract Article PDF–5.5M

Select item 92333008.

HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity

Jae-Su Moon, Matthew Riopel, Jong Bae Seo, Vicente Herrero-Aguayo, Roi Isaac, Yun Sok Lee

Diabetes. 2022 Jul; 71(7): 1508–1524. Published online 2022 Apr 26. doi: 10.2337/db21-0736

PMCID:: PMC9233300

Abstract Article PDF–109M

Select item 88736059.

Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells

Raja Gopal Reddy Mooli, Dhanunjay Mukhi, Anil K. Pasupulati, Simon S. Evers, Ian J. Sipula, Michael Jurczak, Randy J. Seeley, Yatrik M. Shah, Sadeesh K. Ramakrishnan

Cell Mol Gastroenterol Hepatol. 2022; 13(4): 1057–1072. Published online 2021 Dec 11. doi: 10.1016/j.jcmgh.2021.12.004

PMCID:: PMC8873605

Abstract Article PDF–4.1M

Select item 867117710.

Neuronal deficiency of hypoxia-inducible factor 2α increases hypoxic-ischemic brain injury in neonatal mice

Dawei Sun, Fuxin Lu, Ann Sheldon, Xiangning Jiang, Donna M Ferriero

J Neurosci Res. Author manuscript; available in PMC 2022 Nov 1.

Published in final edited form as: J Neurosci Res. 2021 Nov; 99(11): 2964–2975. Published online 2021 Sep 6. doi: 10.1002/jnr.24943

PMCID:: PMC8671177

Abstract Article PDF–1.0M

Select item 830250511.

(H)IF applicable: promotion of neurogenesis by induced HIF-2 signalling after ischaemia

Tristan Leu, Joachim Fandrey, Timm Schreiber

Pflugers Arch. 2021; 473(8): 1287–1299. Published online 2021 Jul 12. doi: 10.1007/s00424-021-02600-8

PMCID:: PMC8302505

Abstract Article PDF–6.1M

Select item 812640912.

Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development

Robin M. Perelli, Matthew L. O'Sullivan, Samantha Zarnick, Jeremy N. Kay

Development. 2021 May 1; 148(9): dev199418. Published online 2021 May 7. doi: 10.1242/dev.199418

PMCID:: PMC8126409

Abstract Article

Select item 810258013.

Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss

Sun Young Lee, Ka Hyon Park, Gyuseok Lee, Su-Jin Kim, Won-Hyun Song, Seung-Hee Kwon, Jeong-Tae Koh, Yun Hyun Huh, Je-Hwang Ryu

Exp Mol Med. 2021 Apr; 53(4): 591–604. Published online 2021 Apr 2. doi: 10.1038/s12276-021-00594-y

PMCID:: PMC8102580

Abstract Article PDF–1.6M

Select item 799552814.

HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Xin Yi Chan, Eugenia Volkova, Joon Eoh, Rebecca Black, Lilly Fang, Rayyan Gorashi, Jihyun Song, Jing Wang, Morgan B. Elliott, Sebastian F. Barreto-Ortiz, James Chen, Brian L. Lin, Lakshmi Santhanam, Linzhao Cheng, Frank S. Lee, Josef T. Prchal, Sharon Gerecht

iScience. 2021 Apr 23; 24(4): 102246. Published online 2021 Mar 2. doi: 10.1016/j.isci.2021.102246

PMCID:: PMC7995528

Abstract Article PDF–8.4M

Select item 764461215.

Hypoxia-inducible factor-2α is crucial for proper brain development

Kira Kleszka, Tristan Leu, Theresa Quinting, Holger Jastrow, Sonali Pechlivanis, Joachim Fandrey, Timm Schreiber

Sci Rep. 2020; 10: 19146. Published online 2020 Nov 5. doi: 10.1038/s41598-020-75838-4

PMCID:: PMC7644612

Abstract Article PDF–3.1M

Select item 739340816.

Inhibition of prolyl hydroxylases increases hepatic insulin and decreases glucagon sensitivity by an HIF-2α-dependent mechanism

Matthew Riopel, Jae-Su Moon, Gautam K. Bandyopadhyay, Seohee You, Kevin Lam, Xiao Liu, Tatiana Kisseleva, David Brenner, Yun Sok Lee

Mol Metab. 2020 Nov; 41: 101039. Published online 2020 Jun 11. doi: 10.1016/j.molmet.2020.101039

PMCID:: PMC7393408

Abstract Article PDF–2.3M

Select item 719092117.

Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control

Xiaotong Cheng, Maria Prange-Barczynska, James W. Fielding, Minghao Zhang, Alana L. Burrell, Joanna D.C.C. Lima, Luise Eckardt, Isobel L.A. Argles, Christopher W. Pugh, Keith J. Buckler, Peter A. Robbins, Emma J. Hodson, Richard K. Bruick, Lucy M. Collinson, Fraydoon Rastinejad, Tammie Bishop, Peter J. Ratcliffe

J Clin Invest. 2020 May 1; 130(5): 2237–2251. Published online 2020 Mar 23. doi: 10.1172/JCI133194