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Select item 59603061.

Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

Weicang Wang, Jun Yang, Jianan Zhang, Yuxin Wang, Sung Hee Hwang, Weipeng Qi, Debin Wan, Daeyoung Kim, Jia Sun, Katherine Z. Sanidad, Haixia Yang, Yeonhwa Park, Jun-Yan Liu, Xinfeng Zhao, Xiaohui Zheng, Zhenhua Liu, Bruce D. Hammock, Guodong Zhang

Proc Natl Acad Sci U S A. 2018 May 15; 115(20): 5283–5288. Published online 2018 May 1. doi: 10.1073/pnas.1721711115

PMCID:: PMC5960306

Abstract Article PDF–1.1M

Select item 56965022.

Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids

Anne Marowsky, Imke Meyer, Kira Erismann-Ebner, Giovanni Pellegrini, Nandkishor Mule, Michael Arand

Arch Toxicol. 2017; 91(11): 3571–3585. Published online 2017 Oct 3. doi: 10.1007/s00204-017-2060-4

PMCID:: PMC5696502

Abstract Article PDF–1.3M

Select item 51048003.

Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation

Anne Marowsky, Karen Haenel, Ernesto Bockamp, Rosario Heck, Sibylle Rutishauser, Nandkishor Mule, Diana Kindler, Markus Rudin, Michael Arand

Arch Toxicol. 2016; 90(12): 3017–3027. Published online 2016 Feb 2. doi: 10.1007/s00204-016-1666-2

PMCID:: PMC5104800

Abstract Article PDF–899K

Select item 40029044.

Hepatitis B spliced protein (HBSP) promotes the carcinogenic effects of benzo [alpha] pyrene by interacting with microsomal epoxide hydrolase and enhancing its hydrolysis activity

Jin-Yan Chen, Wan-Nan Chen, Bo-Yan Jiao, Wan-Song Lin, Yun-Li Wu, Ling-Ling Liu, Xu Lin

BMC Cancer. 2014; 14: 282. Published online 2014 Apr 23. doi: 10.1186/1471-2407-14-282

PMCID:: PMC4002904

Abstract Article PDF–2.0M

Select item 56964935.

Evidence for a complex formation between CYP2J5 and mEH in living cells by FRET analysis of membrane protein interaction in the endoplasmic reticulum (FAMPIR)

Anette Carolina Orjuela Leon, Anne Marwosky, Michael Arand

Arch Toxicol. 2017; 91(11): 3561–3570. Published online 2017 Oct 13. doi: 10.1007/s00204-017-2072-0

PMCID:: PMC5696493

Abstract Article PDF–2.9M

Select item 26541896.

Soluble Epoxide Hydrolase Gene Deletion Is Protective Against Experimental Cerebral Ischemia

Wenri Zhang, Takashi Otsuka, Nobuo Sugo, Ardi Ardeshiri, Yazan K. Alhadid, Jeffrey J. Iliff, Andrea E. DeBarber, Dennis R. Koop, Nabil J. Alkayed

Stroke. Author manuscript; available in PMC 2009 Mar 11.

Published in final edited form as: Stroke. 2008 Jul; 39(7): 2073–2078. Published online 2008 Mar 27. doi: 10.1161/STROKEAHA.107.508325

PMCID:: PMC2654189

Abstract Article PDF–302K

Select item 25276427.

Effect of CYP2E1 Gene Deletion in Mice on Expression of Microsomal Epoxide Hydrolase in Response to VCD Exposure

Aileen F. Keating, Kathila S. Rajapaksa, I. Glenn Sipes, Patricia B. Hoyer

Toxicol Sci. 2008 Oct; 105(2): 351–359. Published online 2008 Jul 12. doi: 10.1093/toxsci/kfn136

PMCID:: PMC2527642

Abstract Article PDF–636K

Select item 79484178.

Epoxide hydrolase 3 (Ephx3) gene disruption reduces ceramide linoleate epoxide hydrolysis and impairs skin barrier function

Matthew L. Edin, Haruto Yamanashi, William E. Boeglin, Joan P. Graves, Laura M. DeGraff, Fred B. Lih, Darryl C. Zeldin, Alan R. Brash

J Biol Chem. 2021 Jan-Jun; 296: 100198. Published online 2021 Jan 21. doi: 10.1074/jbc.RA120.016570

PMCID:: PMC7948417

Abstract Article PDF–738K

Select item 79153069.

Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury

K. Lockhart Jamieson, Ahmed M. Darwesh, Deanna K. Sosnowski, Hao Zhang, Saumya Shah, Pavel Zhabyeyev, Jun Yang, Bruce D. Hammock, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, Zamaneh Kassiri, John M. Seubert

Int J Mol Sci. 2021 Feb; 22(4): 1691. Published online 2021 Feb 8. doi: 10.3390/ijms22041691

PMCID:: PMC7915306

Abstract Article PDF–2.8M

Select item 583613010.

Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia

Matthew L. Edin, Behin Gholipour Hamedani, Artiom Gruzdev, Joan P. Graves, Fred B. Lih, Samuel J. Arbes, III, Rohanit Singh, Anette C. Orjuela Leon, J. Alyce Bradbury, Laura M. DeGraff, Samantha L. Hoopes, Michael Arand, Darryl C. Zeldin

J Biol Chem. 2018 Mar 2; 293(9): 3281–3292. Published online 2018 Jan 3. doi: 10.1074/jbc.RA117.000298

PMCID:: PMC5836130

Abstract Article PDF–2.3M

Select item 361936511.

Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis

Padmini Sirish, Ning Li, Jun-Yan Liu, Kin Sing Stephen Lee, Sung Hee Hwang, Hong Qiu, Cuifen Zhao, Siu Mei Ma, Javier E. López, Bruce D. Hammock, Nipavan Chiamvimonvat

Proc Natl Acad Sci U S A. 2013 Apr 2; 110(14): 5618–5623. Published online 2013 Mar 14. doi: 10.1073/pnas.1221972110

PMCID:: PMC3619365

Abstract Article PDF–1.0M

Select item 31778212.

Sequence and organization of the mouse poly (ADP-ribose) polymerase gene.

K Huppi, K Bhatia, D Siwarski, D Klinman, B Cherney, M Smulson

Nucleic Acids Res. 1989 May 11; 17(9): 3387–3401. doi: 10.1093/nar/17.9.3387

PMCID:: PMC317782

Summary Page Browse PDF–2.0M

Select item 411526613.

Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

Joanne Walsh, Rosalind E. Jenkins, Michael Wong, Adedamola Olayanju, Helen Powell, Ian Copple, Paul M. O’Neill, Christopher E.P. Goldring, Neil R. Kitteringham, B. Kevin Park

J Proteomics. 2014 Aug 28; 108(100): 171–187. doi: 10.1016/j.jprot.2014.05.007

PMCID:: PMC4115266

Abstract Article PDF–859K

Select item 860779714.

A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes

Yu-Shiuan Cheng, Tianyi Zhang, Xiang Ma, Sarida Pratuangtham, Grace C. Zhang, Alexander A. Ondrus, Amirhossein Mafi, Brett Lomenick, Jeffrey J. Jones, Alison E. Ondrus

Nat Chem Biol. Author manuscript; available in PMC 2022 May 19.

Published in final edited form as: Nat Chem Biol. 2021 Dec; 17(12): 1271–1280. Published online 2021 Nov 19. doi: 10.1038/s41589-021-00907-2

PMCID:: PMC8607797

Abstract Article PDF–2.2M

Select item 25668515.

Genetic mapping of endogenous mouse mammary tumor viruses: locus characterization, segregation, and chromosomal distribution.

V L Traina, B A Taylor, J C Cohen

J Virol. 1981 Dec; 40(3): 735–744. doi: 10.1128/jvi.40.3.735-744.1981

PMCID:: PMC256685

Summary Page Browse PDF–1.5M

Select item 38418216.

Association of endogenous viral loci with genes encoding murine histocompatibility and lymphocyte differentiation antigens.

D Meruelo, A Rossomando, M Offer, J Buxbaum, A Pellicer

Proc Natl Acad Sci U S A. 1983 Aug; 80(16): 5032–5036. doi: 10.1073/pnas.80.16.5032

PMCID:: PMC384182

Summary Page Browse PDF–1.6M

Select item 328699417.

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

Irene Kamileri, Ismene Karakasilioti, Aria Sideri, Theodoros Kosteas, Antonis Tatarakis, Iannis Talianidis, George A. Garinis

Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8): 2995–3000. Published online 2012 Feb 8. doi: 10.1073/pnas.1114941109

PMCID:: PMC3286994

Abstract Article PDF–725K

Select item 586277118.

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies

David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael C. Bassik, James K. Chen, Maxence V. Nachury

Nat Genet. Author manuscript; available in PMC 2018 Aug 19.

Published in final edited form as: Nat Genet. 2018 Mar; 50(3): 460–471. Published online 2018 Feb 19. doi: 10.1038/s41588-018-0054-7

PMCID:: PMC5862771

Abstract Article PDF–2.5M

Select item 629804019.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Abstract Article PDF–1.2M

Select item 741599120.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

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