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Select item 61769241.

LIF-dependent survival of embryonic stem cells is regulated by a novel palmitoylated Gab1 signalling protein

Linda Sutherland, Madeleine Ruhe, Daniela Gattegno-Ho, Karanjit Mann, Jennifer Greaves, Magdalena Koscielniak, Stephen Meek, Zen Lu, Martin Waterfall, Ryan Taylor, Anestis Tsakiridis, Helen Brown, Sutherland K. Maciver, Anagha Joshi, Michael Clinton, Luke H. Chamberlain, Austin Smith, Tom Burdon

J Cell Sci. 2018 Sep 15; 131(18): jcs222257. Published online 2018 Sep 20. doi: 10.1242/jcs.222257

PMCID:: PMC6176924

Abstract Article

Select item 30941532.

Endothelial Gab1 is crucial for postnatal angiogenesis

Jinjing Zhao, Weiye Wang, Chang Hoon Ha, Ji Young Kim, Chelsea Wong, Eileen M. Redmond, Anne Hamik, Mukesh K. Jain, Gen-Sheng Feng, Zheng Gen Jin

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2012 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2011 May; 31(5): 1016–1023. Published online 2011 Mar 3. doi: 10.1161/ATVBAHA.111.224493

PMCID:: PMC3094153

Abstract Article PDF–1.4M

Select item 15563773.

Gab1 Is Required for Cell Cycle Transition, Cell Proliferation, and Transformation Induced by an Oncogenic Met Receptor

Kathleen Mood, Caroline Saucier, Yong-Sik Bong, Hyun-Shik Lee, Morag Park, Ira O. Daar

Mol Biol Cell. 2006 Sep; 17(9): 3717–3728. doi: 10.1091/mbc.E06-03-0244

PMCID:: PMC1556377

Abstract Article PDF–2.2M

Select item 3441974.

Role of Gab1 in UV-Induced c-Jun NH₂-Terminal Kinase Activation and Cell Apoptosis

Yingqing Sun, Jing Yuan, Houqi Liu, Zhongqing Shi, Kelly Baker, Kristiina Vuori, Jie Wu, Gen-Sheng Feng

Mol Cell Biol. 2004 Feb; 24(4): 1531–1539. doi: 10.1128/MCB.24.4.1531-1539.2004

PMCID:: PMC344197

Abstract Article PDF–492K

Select item 112107545.

Activated Gab1 drives hepatocyte proliferation and anti-apoptosis in liver fibrosis via potential involvement of the HGF/c-Met signaling axis

Da-eun Nam, Soo-Jeung Park, Samson Omole, Eugene Um, Ramin M. Hakami, Young S. Hahn

PLoS One. 2024; 19(6): e0306345. Published online 2024 Jun 27. doi: 10.1371/journal.pone.0306345

PMCID:: PMC11210754

Abstract Article PDF–2.4M

Select item 100701076.

Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation

Jiaqi Xu, Shihao Li, Wei Jin, Hui Zhou, Tingting Zhong, Xiaoqing Cheng, Yujuan Fu, Peng Xiao, Hongqiang Cheng, Di Wang, Yuehai Ke, Zhinong Jiang, Xue Zhang

JCI Insight. 2023 Mar 22; 8(6): e162701. Published online 2023 Mar 22. doi: 10.1172/jci.insight.162701

PMCID:: PMC10070107

Abstract Article PDF–24M

Select item 77163987.

S100a8 silencing attenuates inflammation, oxidative stress and apoptosis in BV2 cells induced by oxygen-glucose deprivation and reoxygenation by upregulating GAB1 expression

Wenguang Hu, Caimei Lin

Mol Med Rep. 2021 Jan; 23(1): 64. Published online 2020 Nov 19. doi: 10.3892/mmr.2020.11702

PMCID:: PMC7716398

Abstract Article PDF–1.3M

Select item 71899838.

Cholinergic Grb2-Associated-Binding Protein 1 Regulates Cognitive Function

Nan-Nan Lu, Chao Tan, Ning-He Sun, Ling-Xiao Shao, Xiu-Xiu Liu, Yin-Ping Gao, Rong-Rong Tao, Quan Jiang, Cheng-Kun Wang, Ji-Yun Huang, Kui Zhao, Guang-Fa Wang, Zhi-Rong Liu, Kohji Fukunaga, Ying-Mei Lu, Feng Han

Cereb Cortex. 2018 Jul; 28(7): 2391–2404. Published online 2017 Jun 7. doi: 10.1093/cercor/bhx141

PMCID:: PMC7189983

Abstract Article PDF–1.5M

Select item 69386239.

Inhibition of microRNA-29a alleviates hyperoxia-induced bronchopulmonary dysplasia in neonatal mice via upregulation of GAB1

Yu Hu, Liang Xie, Jing Yu, Hongling Fu, Dan Zhou, Hanmin Liu

Mol Med. 2020; 26: 3. Published online 2019 Dec 31. doi: 10.1186/s10020-019-0127-9

PMCID:: PMC6938623

Abstract Article PDF–2.3M

Select item 509987310.

Scaffolding protein Gab1 regulates myeloid dendritic cell migration in allergic asthma

Yun Zhang, Yun Xu, Shuwan Liu, Xiaohong Guo, Dong Cen, Jiaqi Xu, Heyuan Li, Kaijun Li, Chunlai Zeng, Linrong Lu, Yiting Zhou, Huahao Shen, Hongqiang Cheng, Xue Zhang, Yuehai Ke

Cell Res. 2016 Nov; 26(11): 1226–1241. Published online 2016 Nov 4. doi: 10.1038/cr.2016.124

PMCID:: PMC5099873

Abstract Article PDF–5.8M

Select item 339359911.

Gab1 Mediates Hepatocyte Growth Factor-Stimulated Mitogenicity and Morphogenesis in Multipotent Myeloid Cells

Angelina Felici, Alessio Giubellino, Donald P. Bottaro

J Cell Biochem. Author manuscript; available in PMC 2012 Jul 10.

Published in final edited form as: J Cell Biochem. 2010 Oct 1; 111(2): 310–321. doi: 10.1002/jcb.22695

PMCID:: PMC3393599

Abstract Article PDF–6.0M

Select item 304106612.

Grb-2–associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A–endothelial NOS pathway

Yao Lu, Yan Xiong, Yingqing Huo, Jingyan Han, Xiao Yang, Rongli Zhang, De-Sheng Zhu, Stefan Klein-Heßling, Jun Li, Xiaoyu Zhang, Xiaofan Han, Yanli Li, Bin Shen, Yulong He, Masabumi Shibuya, Gen-Sheng Feng, Jincai Luo

Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7): 2957–2962. Published online 2011 Jan 31. doi: 10.1073/pnas.1009395108

PMCID:: PMC3041066

Abstract Article PDF–1.0M

Select item 8566613.

Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation

Motoyuki Itoh, Yuichi Yoshida, Keigo Nishida, Masahiro Narimatsu, Masahiko Hibi, Toshio Hirano

Mol Cell Biol. 2000 May; 20(10): 3695–3704. doi: 10.1128/mcb.20.10.3695-3704.2000

PMCID:: PMC85666

Abstract Article PDF–3.0M

Select item 498664114.

Cardiac Gab1 deletion leads to dilated cardiomyopathy associated with mitochondrial damage and cardiomyocyte apoptosis

J Zhao, M Yin, H Deng, F Q Jin, S Xu, Y Lu, M A Mastrangelo, H Luo, Z G Jin

Cell Death Differ. 2016 Apr; 23(4): 695–706. Published online 2015 Oct 30. doi: 10.1038/cdd.2015.143

PMCID:: PMC4986641

Abstract Article PDF–2.7M

Select item 148912915.

Concerted Functions of Gab1 and Shp2 in Liver Regeneration and Hepatoprotection

Emilie A. Bard-Chapeau, Jing Yuan, Nathalie Droin, Shinong Long, Eric E. Zhang, Thanh V. Nguyen, Gen-Sheng Feng

Mol Cell Biol. 2006 Jun; 26(12): 4664–4674. doi: 10.1128/MCB.02253-05

PMCID:: PMC1489129

Abstract Article PDF–799K

Select item 48089116.

The Docking Protein Gab1 Is an Essential Component of an Indirect Mechanism for Fibroblast Growth Factor Stimulation of the Phosphatidylinositol 3-Kinase/Akt Antiapoptotic Pathway

Betty Lamothe, Masashi Yamada, Ute Schaeper, Walter Birchmeier, Irit Lax, Joseph Schlessinger

Mol Cell Biol. 2004 Jul; 24(13): 5657–5666. doi: 10.1128/MCB.24.13.5657-5666.2004

PMCID:: PMC480891

Abstract Article PDF–563K

Select item 11763017.

Distinct Recruitment and Function of Gab1 and Gab2 in Met Receptor-mediated Epithelial Morphogenesis

Lisa S. Lock, Christiane R. Maroun, Monica A. Naujokas, Morag Park

Mol Biol Cell. 2002 Jun; 13(6): 2132–2146. doi: 10.1091/mbc.02-02-0031.

PMCID:: PMC117630

Abstract Article PDF–733K

Select item 719536218.

Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes enlargement of cloned mouse placentas

Kimiko Inoue, Narumi Ogonuki, Satoshi Kamimura, Hiroki Inoue, Shogo Matoba, Michiko Hirose, Arata Honda, Kento Miura, Masashi Hada, Ayumi Hasegawa, Naomi Watanabe, Yukiko Dodo, Keiji Mochida, Atsuo Ogura

Nat Commun. 2020; 11: 2150. Published online 2020 May 1. doi: 10.1038/s41467-020-16044-8

PMCID:: PMC7195362

Abstract Article PDF–2.8M

Select item 557290919.

Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice

Xiaohong Guo, Tingting Li, Yun Xu, Xiayan Xu, Zhengyi Zhu, Yun Zhang, Jiaqi Xu, Kaihong Xu, Hongqiang Cheng, Xue Zhang, Yuehai Ke

J Biol Chem. 2017 Aug 25; 292(34): 14003–14015. Published online 2017 Jul 7. doi: 10.1074/jbc.M117.802066

PMCID:: PMC5572909

Abstract Article PDF–3.4M

Select item 440318820.

Gα_i1 and Gα_i3 regulate macrophage polarization by forming a complex containing CD14 and Gab1

Xianjing Li, Duowei Wang, Zhen Chen, Ermei Lu, Zhuo Wang, Jingjing Duan, Wei Tian, Yun Wang, Linjun You, Yulian Zou, Yan Cheng, Qingyi Zhu, Xiaojian Wan, Tao Xi, Meisheng Jiang, Yuyuan Han, Cong Cao, Lutz Birnbaumer, Wen-Ming Chu, Yong Yang

Proc Natl Acad Sci U S A. 2015 Apr 14; 112(15): 4731–4736. Published online 2015 Mar 30. doi: 10.1073/pnas.1503779112