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Select item 106564441.

GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

Di-Xian Wang, Zhao-Jun Dong, Sui-Xin Deng, Ying-Ming Tian, Yu-Jie Xiao, Xinran Li, Xiao-Ru Ma, Liang Li, Pengxiao Li, Hui-Zhong Chang, Longqi Liu, Fan Wang, Yang Wu, Xiang Gao, Shuang-Shuang Zheng, Hui-Min Gu, Ya-Nan Zhang, Jian-Bin Wu, Fan Wu, Yonglin Peng, Xiao-Wen Zhang, Ren-Ya Zhan, Li-Xia Gao, Qiming Sun, Xing Guo, Xiao-Dong Zhao, Jian-Hong Luo, Ruhong Zhou, Lei Han, Yousheng Shu, Jing-Wei Zhao

Nat Commun. 2023; 14: 7476. Published online 2023 Nov 17. doi: 10.1038/s41467-023-43292-1

PMCID:: PMC10656444

Abstract Article PDF–14M

Select item 101541972.

Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy

Carine Moigneu, Soumia Abdellaoui, Mariana Ramos-Brossier, Bianca Pfaffenseller, Bianca Wollenhaupt-Aguiar, Taiane de Azevedo Cardoso, Claire Camus, Aurélie Chiche, Nicolas Kuperwasser, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira, Han Li, Franck Oury, Flávio Kapczinski, Pierre-Marie Lledo, Lida Katsimpardi

Nat Aging. 2023; 3(2): 213–228. Published online 2023 Feb 2. doi: 10.1038/s43587-022-00352-3

Correction in:: Nat Aging. 2023; 3(8): 1036.

PMCID:: PMC10154197

Abstract Article PDF–5.6M

Select item 84226693.

GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

Brittany A. Mayweather, Sean M. Buchanan, Lee L. Rubin

Mol Brain. 2021; 14: 134. Published online 2021 Sep 6. doi: 10.1186/s13041-021-00845-z

PMCID:: PMC8422669

Abstract Article PDF–2.2M

Select item 82537744.

Growth differentiation factor 11 attenuates cardiac ischemia reperfusion injury via enhancing mitochondrial biogenesis and telomerase activity

Lin Chen, Guangjin Luo, Yameng Liu, Hairuo Lin, Cankun Zheng, Dongxiao Xie, Yingqi Zhu, Lu Chen, Xiaoxia Huang, Donghong Hu, Jiahe Xie, Zhenhuan Chen, Wangjun Liao, Jianping Bin, Qiancheng Wang, Yulin Liao

Cell Death Dis. 2021 Jul; 12(7): 665. Published online 2021 Jul 2. doi: 10.1038/s41419-021-03954-8

PMCID:: PMC8253774

Abstract Article PDF–3.3M

Select item 77328955.

Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?

Jan Frohlich, Manlio Vinciguerra

GeroScience. 2020 Dec; 42(6): 1475–1498. Published online 2020 Oct 6. doi: 10.1007/s11357-020-00279-w

PMCID:: PMC7732895

Abstract Article PDF–814K

Select item 74126886.

Growth differentiation factor 11 promotes differentiation of MSCs into endothelial‐like cells for angiogenesis

Chi Zhang, Yinuo Lin, Qi Liu, Junhua He, Pingping Xiang, Dianliang Wang, Xinyang Hu, Jinghai Chen, Wei Zhu, Hong Yu

J Cell Mol Med. 2020 Aug; 24(15): 8703–8717. Published online 2020 Jun 25. doi: 10.1111/jcmm.15502

PMCID:: PMC7412688

Abstract Article PDF–2.9M

Select item 69747187.

Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction‐like phenotype in aged mice

Lida Katsimpardi, Nicolas Kuperwasser, Claire Camus, Carine Moigneu, Aurélie Chiche, Virginie Tolle, Han Li, Erzsebet Kokovay, Pierre‐Marie Lledo

Aging Cell. 2020 Jan; 19(1): e13038. Published online 2019 Oct 22. doi: 10.1111/acel.13038

PMCID:: PMC6974718

Abstract Article PDF–1.2M

Select item 69015118.

Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus

Jill M. Goldstein, Austin Valido, Jordan P. Lewandowski, Ryan G. Walker, Melanie J. Mills, Kathleen A. Messemer, Paul Besseling, Kyu Ha Lee, Samuel J. Wattrus, Miook Cho, Richard T. Lee, Amy J. Wagers

Sci Rep. 2019; 9: 18613. Published online 2019 Dec 9. doi: 10.1038/s41598-019-54766-y

PMCID:: PMC6901511

Abstract Article PDF–5.7M

Select item 67721699.

Growth differentiation factor 11 locally controls anterior–posterior patterning of the axial skeleton

Joonho Suh, Je‐Hyun Eom, Na‐Kyung Kim, Kyung Mi Woo, Jeong‐Hwa Baek, Hyun‐Mo Ryoo, Se‐Jin Lee, Yun‐Sil Lee

J Cell Physiol. 2019 Dec; 234(12): 23360–23368. Published online 2019 Jun 10. doi: 10.1002/jcp.28904

PMCID:: PMC6772169

Abstract Article PDF–1.8M

Select item 669273610.

Analysis of Cre-mediated genetic deletion of Gdf11 in cardiomyocytes of young mice

Jessica Garbern, Amy C. Kristl, Vinicius Bassaneze, Ana Vujic, Henk Schoemaker, Rebecca Sereda, Liming Peng, Elisabeth M. Ricci-Blair, Jill M. Goldstein, Ryan G. Walker, Shalender Bhasin, Amy J. Wagers, Richard T. Lee

Am J Physiol Heart Circ Physiol. 2019 Jul 1; 317(1): H201–H212. Published online 2019 May 24. doi: 10.1152/ajpheart.00615.2018

PMCID:: PMC6692736

Abstract Article

Select item 639738511.

Inhibitory effects of growth differentiation factor 11 on autophagy deficiency-induced dedifferentiation of arterial smooth muscle cells

Xinxu Yuan, Owais M. Bhat, Hannah Lohner, Ningjun Li, Yang Zhang, Pin-Lan Li

Am J Physiol Heart Circ Physiol. 2019 Feb 1; 316(2): H345–H356. Published online 2018 Nov 21. doi: 10.1152/ajpheart.00342.2018

PMCID:: PMC6397385

Abstract Article

Select item 605631712.

GDF11 induces kidney fibrosis, renal cell epithelial-to-mesenchymal transition and kidney dysfunction and failure

Marianne Pons, Leonidas G. Koniaris, Sharon M. Moe, Juan C. Gutierrez, Aurora Esquela-Kerscher, Teresa A. Zimmers

Surgery. Author manuscript; available in PMC 2019 Aug 1.

Published in final edited form as: Surgery. 2018 Aug; 164(2): 262–273. Published online 2018 May 3. doi: 10.1016/j.surg.2018.03.008

PMCID:: PMC6056317

Abstract Article PDF–2.8M

Select item 505040813.

GDF11 improves tubular regeneration after acute kidney injury in elderly mice

Ying Zhang, Qinggang Li, Dong Liu, Qi Huang, Guangyan Cai, Shaoyuan Cui, Xuefeng Sun, Xiangmei Chen

Sci Rep. 2016; 6: 34624. Published online 2016 Oct 5. doi: 10.1038/srep34624

PMCID:: PMC5050408

Abstract Article PDF–3.5M

Select item 426034214.

An ingredient for the elixir of youth

Rebecca E Andersen, Daniel A Lim

Cell Res. 2014 Dec; 24(12): 1381–1382. Published online 2014 Aug 12. doi: 10.1038/cr.2014.107

PMCID:: PMC4260342

Article PDF–778K

Select item 367713215.

Growth Differentiation Factor 11 is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

Francesco S. Loffredo, Matthew L. Steinhauser, Steven M. Jay, Joseph Gannon, James R. Pancoast, Pratyusha Yalamanchi, Manisha Sinha, Claudia Dall’Osso, Danika Khong, Jennifer L. Shadrach, Christine M. Miller, Britta S. Singer, Alex Stewart, Nikolaos Psychogios, Robert E. Gerszten, Adam J. Hartigan, Mi-Jeong Kim, Thomas Serwold, Amy J. Wagers, Richard T. Lee

Cell. Author manuscript; available in PMC 2014 May 9.

Published in final edited form as: Cell. 2013 May 9; 153(4): 828–839. doi: 10.1016/j.cell.2013.04.015

PMCID:: PMC3677132

Abstract Article PDF–5.6M

Select item 1097873516.

Functional analysis of a first hindlimb positioning enhancer via Gdf11 expression

Seiji Saito, Utsugi Kanazawa, Ayana Tatsumi, Atsuo Iida, Tatsuya Takemoto, Takayuki Suzuki

Front Cell Dev Biol. 2024; 12: 1302141. Published online 2024 Mar 15. doi: 10.3389/fcell.2024.1302141

PMCID:: PMC10978735

Abstract Article PDF–3.4M

Select item 1075758517.

Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans

Simon Kraler, Carolina Balbi, Daria Vdovenko, Tetiana Lapikova-Bryhinska, Giovanni G Camici, Luca Liberale, Nicole Bonetti, Candela Diaz Canestro, Fabienne Burger, Aline Roth, Federico Carbone, Giuseppe Vassalli, François Mach, Shalender Bhasin, Florian A Wenzl, Olivier Muller, Lorenz Räber, Christian M Matter, Fabrizio Montecucco, Thomas F Lüscher, Alexander Akhmedov

Cardiovasc Res. 2023 Dec; 119(17): 2729–2742. Published online 2023 Sep 23. doi: 10.1093/cvr/cvad153

PMCID:: PMC10757585

Abstract Article PDF–7.2M

Select item 983466318.

Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle

John Lian, Ryan G Walker, Andrea D’Amico, Ana Vujic, Melanie J Mills, Kathleen A Messemer, Kourtney R Mendello, Jill M Goldstein, Krystynne A Leacock, Soraya Epp, Emma V Stimpfl, Thomas B Thompson, Amy J Wagers, Richard T Lee

Life Sci Alliance. 2023 Mar; 6(3): e202201662. Published online 2023 Jan 11. doi: 10.26508/lsa.202201662

PMCID:: PMC9834663

Abstract Article PDF–3.3M

Select item 876101119.

Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy

Jian Sun, Ying Li, Xiao Yang, Wei Dong, Jiankun Yang, Qi Hu, Cuntai Zhang, Haoshu Fang, Anding Liu

Aging Cell. 2022 Jan; 21(1): e13532. Published online 2021 Dec 14. doi: 10.1111/acel.13532

PMCID:: PMC8761011

Abstract Article PDF–1.6M

Select item 757626920.

Endogenous GDF11 regulates odontogenic differentiation of dental pulp stem cells

Xingying Qi, Qingyue Xiao, Rui Sheng, Shuang Jiang, Quan Yuan, Weiqing Liu

J Cell Mol Med. 2020 Oct; 24(19): 11457–11464. Published online 2020 Aug 26. doi: 10.1111/jcmm.15754

PMCID:: PMC7576269

Abstract Article PDF–875K

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