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Select item 110707081.

Stimulating intestinal GIP release reduces food intake and body weight in mice

Jo E. Lewis, Danae Nuzzaci, Paula-Peace James-Okoro, Mireia Montaner, Elisabeth O'Flaherty, Tamana Darwish, Marito Hayashi, Stephen D. Liberles, David Hornigold, Jacqueline Naylor, David Baker, Fiona M. Gribble, Frank Reimann

Mol Metab. 2024 Jun; 84: 101945. Published online 2024 Apr 21. doi: 10.1016/j.molmet.2024.101945

PMCID:: PMC11070708

Abstract Article PDF–3.0M

Select item 93264912.

Noninvasive Evaluation of GIP Effects on β-Cell Mass Under High-Fat Diet

Sakura Kiyobayashi, Takaaki Murakami, Norio Harada, Hiroyuki Fujimoto, Yuki Murata, Naotaka Fujita, Keita Hamamatsu, Eri Ikeguchi-Ogura, Tomonobu Hatoko, Xuejing Lu, Shunsuke Yamane, Nobuya Inagaki

Front Endocrinol (Lausanne) 2022; 13: 921125. Published online 2022 Jul 12. doi: 10.3389/fendo.2022.921125

PMCID:: PMC9326491

Abstract Article PDF–2.7M

Select item 83829973.

Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK

Yuki Murata, Norio Harada, Shigenobu Kishino, Kanako Iwasaki, Eri Ikeguchi-Ogura, Shunsuke Yamane, Tomoko Kato, Yoshinori Kanemaru, Akiko Sankoda, Tomonobu Hatoko, Sakura Kiyobayashi, Jun Ogawa, Akira Hirasawa, Nobuya Inagaki

iScience. 2021 Sep 24; 24(9): 102963. Published online 2021 Aug 9. doi: 10.1016/j.isci.2021.102963

PMCID:: PMC8382997

Abstract Article PDF–3.1M

Select item 70404584.

Absence of GIP secretion alleviates age-related obesity and insulin resistance

Yoshinori Kanemaru, Norio Harada, Satoko Shimazu-Kuwahara, Shunsuke Yamane, Eri Ikeguchi, Yuki Murata, Sakura Kiyobayashi, Tomonobu Hatoko, Nobuya Inagaki

J Endocrinol. 2020 Apr; 245(1): 13–20. Published online 2020 Jan 23. doi: 10.1530/JOE-19-0477

PMCID:: PMC7040458

Abstract Article PDF–1.1M

Select item 45344135.

Gastric Inhibitory Polypeptide (GIP) Is Selectively Decreased in the Roux-Limb of Dietary Obese Mice after RYGB Surgery

Jiaqiang Zhou, Zheng Hao, Nigel Irwin, Hans-Rudolf Berthoud, Jianping Ye

PLoS One. 2015; 10(8): e0134728. Published online 2015 Aug 12. doi: 10.1371/journal.pone.0134728

PMCID:: PMC4534413

Abstract Article PDF–2.6M

Select item 67696706.

Diet-Induced Obese Mice and Leptin-Deficient Lep^ob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms

Eunyoung Lee, Emily L. Miedzybrodzka, Xilin Zhang, Ryo Hatano, Junki Miyamoto, Ikuo Kimura, Kosuke Fujimoto, Satoshi Uematsu, Sergio Rodriguez-Cuenca, Antonio Vidal-Puig, Fiona M. Gribble, Frank Reimann, Takashi Miki

Int J Mol Sci. 2019 Sep; 20(18): 4448. Published online 2019 Sep 10. doi: 10.3390/ijms20184448

PMCID:: PMC6769670

Abstract Article PDF–3.5M

Select item 64145487.

HNF4α is a novel regulator of intestinal glucose-dependent insulinotropic polypeptide

Romain Girard, Mathieu Darsigny, Christine Jones, Faïza Maloum-Rami, Yves Gélinas, André C. Carpentier, Mathieu Laplante, Nathalie Perreault, François Boudreau

Sci Rep. 2019; 9: 4200. Published online 2019 Mar 12. doi: 10.1038/s41598-019-41061-z

PMCID:: PMC6414548

Abstract Article PDF–5.7M

Select item 38402338.

Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum

Steven D. Coon, John H. Schwartz, Vazhaikkurichi M. Rajendran, Lisa Jepeal, Satish K. Singh

Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15; 305(10): G678–G684. Published online 2013 Sep 26. doi: 10.1152/ajpgi.00098.2013

PMCID:: PMC3840233

Abstract Article

Select item 37595169.

Regulation of the Pro-inflammatory Cytokine Osteopontin by GIP in Adipocytes - A role for the Transcription Factor NFAT and Phosphodiesterase 3B

Bilal Omar, Elin Banke, Emilia Guiguis, Lina Åkesson, Vincent Manganiello, Valeriya Lyssenko, Leif Groop, Maria F. Gomez, Eva Degerman

Biochem Biophys Res Commun. Author manuscript; available in PMC 2013 Sep 7.

Published in final edited form as: Biochem Biophys Res Commun. 2012 Sep 7; 425(4): 812–817. Published online 2012 Aug 7. doi: 10.1016/j.bbrc.2012.07.157

PMCID:: PMC3759516

Abstract Article PDF–1.5M

Select item 354850110.

Transcriptional Regulatory Factor X6 (Rfx6) Increases Gastric Inhibitory Polypeptide (GIP) Expression in Enteroendocrine K-cells and Is Involved in GIP Hypersecretion in High Fat Diet-induced Obesity

Kazuyo Suzuki, Norio Harada, Shunsuke Yamane, Yasuhiko Nakamura, Kazuki Sasaki, Daniela Nasteska, Erina Joo, Kimitaka Shibue, Takanari Harada, Akihiro Hamasaki, Kentaro Toyoda, Kazuaki Nagashima, Nobuya Inagaki

J Biol Chem. 2013 Jan 18; 288(3): 1929–1938. Published online 2012 Nov 28. doi: 10.1074/jbc.M112.423137

PMCID:: PMC3548501

Abstract Article PDF–2.4M

Select item 316132511.

Pleiotropic Effects of GIP on Islet Function Involve Osteopontin

Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, Albert Salehi, Anna Wendt, Anna Jonsson, Yang Z. De Marinis, Lisa M. Berglund, Jalal Taneera, Alexander Balhuizen, Ola Hansson, Peter Osmark, Pontus Dunér, Charlotte Brøns, Alena Stančáková, Johanna Kuusisto, Marco Bugliani, Richa Saxena, Emma Ahlqvist, Timothy J. Kieffer, Tiinamaija Tuomi, Bo Isomaa, Olle Melander, Emily Sonestedt, Marju Orho-Melander, Peter Nilsson, Sara Bonetti, Riccardo Bonadonna, Roberto Miccoli, Stefano DelPrato, Piero Marchetti, Sten Madsbad, Pernille Poulsen, Allan Vaag, Markku Laakso, Maria F. Gomez, Leif Groop

Diabetes. 2011 Sep; 60(9): 2424–2433. Published online 2011 Aug 20. doi: 10.2337/db10-1532

Correction in:: Diabetes. 2012 Jun; 61(6): 1648.

PMCID:: PMC3161325

Abstract Article PDF–1.1M

Select item 283473612.

A GIP Receptor Agonist Exhibits β-Cell Anti-Apoptotic Actions in Rat Models of Diabetes Resulting in Improved β-Cell Function and Glycemic Control

Scott B. Widenmaier, Su-Jin Kim, Gary K. Yang, Thomas De Los Reyes, Cuilan Nian, Ali Asadi, Yutaka Seino, Timothy J. Kieffer, Yin Nam Kwok, Christopher H. S. McIntosh

PLoS One. 2010; 5(3): e9590. Published online 2010 Mar 9. doi: 10.1371/journal.pone.0009590

PMCID:: PMC2834736

Abstract Article PDF–720K

Select item 270793013.

GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage

Lisa I. Jepeal, Michael O. Boylan, M. Michael Wolfe

Mol Cell Endocrinol. Author manuscript; available in PMC 2009 Jul 9.

Published in final edited form as: Mol Cell Endocrinol. 2008 Jun 11; 287(1-2): 20–29. Published online 2008 Feb 8. doi: 10.1016/j.mce.2008.01.024

PMCID:: PMC2707930

Abstract Article PDF–1.1M

Select item 244059514.

Targeted Ablation of Glucose-dependent Insulinotropic Polypeptide-producing Cells in Transgenic Mice Reduces Obesity and Insulin Resistance Induced by a High Fat Diet

Matthew C. Althage, Eric L. Ford, Songyan Wang, Patrick Tso, Kenneth S. Polonsky, Burton M. Wice

J Biol Chem. 2008 Jun 27; 283(26): 18365–18376. doi: 10.1074/jbc.M710466200

PMCID:: PMC2440595

Abstract Article PDF–585K

Select item 788321615.

Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays

Geke Aline Boer, Bolette Hartmann, Jens Juul Holst

Peptides. 2021 Feb; 136: 170457. doi: 10.1016/j.peptides.2020.170457

PMCID:: PMC7883216

Abstract Article

Select item 541478916.

RNA-Seq Analysis of Enteroendocrine Cells Reveals a Role for FABP5 in the Control of GIP Secretion

Cesar A. Sommer, Gustavo Mostoslavsky

Mol Endocrinol. 2014 Nov; 28(11): 1855–1865. Published online 2014 Sep 30. doi: 10.1210/me.2014-1194

PMCID:: PMC5414789

Abstract Article

Select item 516124317.

Downregulation of a GPCR by β-Arrestin2-mediated Switch from an Endosomal to a TGN Recycling Pathway

Nazish Abdullah, Muheeb Beg, David Soares, Jeremy S. Dittman, Timothy E McGraw

Cell Rep. Author manuscript; available in PMC 2017 Dec 13.

Published in final edited form as: Cell Rep. 2016 Dec 13; 17(11): 2966–2978. doi: 10.1016/j.celrep.2016.11.050

PMCID:: PMC5161243

Abstract Article PDF–2.0M

Select item 355436018.

Ectopic Expression of GIP in Pancreatic β-Cells Maintains Enhanced Insulin Secretion in Mice With Complete Absence of Proglucagon-Derived Peptides

Ayako Fukami, Yusuke Seino, Nobuaki Ozaki, Michiyo Yamamoto, Chisato Sugiyama, Eriko Sakamoto-Miura, Tatsuhito Himeno, Yoshiko Takagishi, Shin Tsunekawa, Safina Ali, Daniel J. Drucker, Yoshiharu Murata, Yutaka Seino, Yutaka Oiso, Yoshitaka Hayashi

Diabetes. 2013 Feb; 62(2): 510–518. Published online 2013 Jan 17. doi: 10.2337/db12-0294

PMCID:: PMC3554360

Abstract Article PDF–1.7M

Select item 768575619.

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

Okechi S. Oduori, Naoya Murao, Kenju Shimomura, Harumi Takahashi, Quan Zhang, Haiqiang Dou, Shihomi Sakai, Kohtaro Minami, Belen Chanclon, Claudia Guida, Lakshmi Kothegala, Johan Tolö, Yuko Maejima, Norihide Yokoi, Yasuhiro Minami, Takashi Miki, Patrik Rorsman, Susumu Seino

J Clin Invest. 2020 Dec 1; 130(12): 6639–6655. Published online 2020 Nov 16. doi: 10.1172/JCI140046

PMCID:: PMC7685756

Abstract Article PDF–6.7M

Select item 476109320.

Galanin inhibits GLP‐1 and GIP secretion via the GAL₁ receptor in enteroendocrine L and K cells

Arianna Psichas, Leslie L Glass, Stephen J Sharp, Frank Reimann, Fiona M Gribble

Br J Pharmacol. 2016 Mar; 173(5): 888–898. Published online 2016 Feb 8. doi: 10.1111/bph.13407

PMCID:: PMC4761093

Abstract Article PDF–1.2M

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