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Select item 32585921.

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain

Maria Kauppi, Adrienne A. Hilton, Donald Metcalf, Ashley P. Ng, Craig D. Hyland, Janelle E. Collinge, Benjamin T. Kile, Douglas J. Hilton, Warren S. Alexander

Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2): 576–581. Published online 2011 Dec 27. doi: 10.1073/pnas.1119146109

PMCID:: PMC3258592

Abstract Article PDF–555K

Select item 28116972.

Effects of human γ-globin in murine β-thalassaemia

Tamon Nishino, Hua Cao, George Stamatoyannopoulos, David W. Emery

Br J Haematol. Author manuscript; available in PMC 2010 Jan 26.

Published in final edited form as: Br J Haematol. 2006 Jul; 134(1): 100–108. doi: 10.1111/j.1365-2141.2006.06102.x

PMCID:: PMC2811697

Abstract Article PDF–1.6M

Select item 219683.

Hemoglobin induction in mouse macrophages

Limin Liu, Ming Zeng, Jonathan S. Stamler

Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12): 6643–6647. doi: 10.1073/pnas.96.12.6643

PMCID:: PMC21968

Abstract Article PDF–140K

Select item 91402864.

High phosphate intake induces bone loss in nephrectomized thalassemic mice

Sasithorn Wanna-udom, Chainarong Luesiripong, Nithidol Sakunrangsit, Piyanuch Metheepakornchai, Sitthichai Intharamonthian, Saovaros Svasti, Matthew B. Greenblatt, Asada Leelahavanichkul, Sutada Lotinun

PLoS One. 2022; 17(5): e0268732. Published online 2022 May 27. doi: 10.1371/journal.pone.0268732

PMCID:: PMC9140286

Abstract Article PDF–3.5M

Select item 89938755.

Mild-intensity physical activity prevents cardiac and osseous iron deposition without affecting bone mechanical property or porosity in thalassemic mice

Narattaphol Charoenphandhu, Supagarn Sooksawanwit, Ratchaneevan Aeimlapa, Natchayaporn Thonapan, Pornpailin Upanan, Punyanuch Adulyaritthikul, Saowalak Krungchanuchat, Nattapon Panupinthu, Jarinthorn Teerapornpuntakit, Catleya Rojviriya, Kornkamon Lertsuwan, Saovaros Svasti, Kannikar Wongdee

Sci Rep. 2022; 12: 5959. Published online 2022 Apr 8. doi: 10.1038/s41598-022-09997-x

PMCID:: PMC8993875

Abstract Article PDF–1.9M

Select item 81215266.

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model

Alessandro Matte, Enrica Federti, Charles Kung, Penelope A. Kosinski, Rohini Narayanaswamy, Roberta Russo, Giorgia Federico, Francesca Carlomagno, Maria Andrea Desbats, Leonardo Salviati, Christophe Leboeuf, Maria Teresa Valenti, Francesco Turrini, Anne Janin, Shaoxia Yu, Elisabetta Beneduce, Sebastien Ronseaux, Iana Iatcenko, Lenny Dang, Tomas Ganz, Chun-Ling Jung, Achille Iolascon, Carlo Brugnara, Lucia De Franceschi

J Clin Invest. 2021 May 17; 131(10): e144206. Published online 2021 May 17. doi: 10.1172/JCI144206

PMCID:: PMC8121526

Abstract Article PDF–6.3M

Select item 75475337.

Hematopoietic stem cell function in β-thalassemia is impaired and is rescued by targeting the bone marrow niche

Annamaria Aprile, Alessandro Gulino, Mariangela Storto, Isabella Villa, Stefano Beretta, Ivan Merelli, Alessandro Rubinacci, Maurilio Ponzoni, Sarah Marktel, Claudio Tripodo, Maria Rosa Lidonnici, Giuliana Ferrari

Blood. 2020 Jul 30; 136(5): 610–622. Prepublished online 2020 Apr 28. doi: 10.1182/blood.2019002721

PMCID:: PMC7547533

Abstract Article

Select item 72109548.

Nephrectomy Does not Exacerbate Cancellous Bone loss in Thalassemic Mice

Sutada Lotinun, Korakot Atjanasuppat, Jutatip Limsuvech, Asada Leelahavanichkul, Saovaros Svasti, Nateetip Krishnamra

Sci Rep. 2020; 10: 7786. Published online 2020 May 8. doi: 10.1038/s41598-020-64681-2

PMCID:: PMC7210954

Abstract Article PDF–4.6M

Select item 63552199.

In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia

Hongjie Wang, Aphrodite Georgakopoulou, Nikoletta Psatha, Chang Li, Chrysi Capsali, Himanshu Bhusan Samal, Achilles Anagnostopoulos, Anja Ehrhardt, Zsuzsanna Izsvák, Thalia Papayannopoulou, Evangelia Yannaki, André Lieber

J Clin Invest. 2019 Feb 1; 129(2): 598–615. Published online 2018 Dec 18. doi: 10.1172/JCI122836

PMCID:: PMC6355219

Abstract Article PDF–13M

Select item 515449510.

Evaluation of Stem Cell-Derived Red Blood Cells as a Transfusion Product Using a Novel Animal Model

Sandeep N. Shah, Monique P. Gelderman, Emily M. A. Lewis, John Farrel, Francine Wood, Michael Brad Strader, Abdu I. Alayash, Jaroslav G. Vostal

PLoS One. 2016; 11(12): e0166657. Published online 2016 Dec 13. doi: 10.1371/journal.pone.0166657

PMCID:: PMC5154495

Abstract Article PDF–2.4M

Select item 442021011.

Reversal of hemochromatosis by apotransferrin in non-transfused and transfused Hbb^th3/+ (heterozygous b1/b2 globin gene deletion) mice

Monique P. Gelderman, Jin Hyen Baek, Ayla Yalamanoglu, Michele Puglia, Florence Vallelian, Bo Burla, Jaroslav Vostal, Dominik J. Schaer, Paul W. Buehler

Haematologica. 2015 May; 100(5): 611–622. doi: 10.3324/haematol.2014.117325

PMCID:: PMC4420210

Abstract Article PDF–1.7M

Select item 349775812.

Neutralizing the function of a β-globin–associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain

Joeva J. Barrow, Jude Masannat, Jörg Bungert

Proc Natl Acad Sci U S A. 2012 Oct 30; 109(44): 17948–17953. Published online 2012 Oct 16. doi: 10.1073/pnas.1207677109

PMCID:: PMC3497758

Abstract Article PDF–729K

Select item 336961513.

Integrated protein quality-control pathways regulate free α-globin in murine β-thalassemia

Eugene Khandros, Christopher S. Thom, Janine D'Souza, Mitchell J. Weiss

Blood. 2012 May 31; 119(22): 5265–5275. Prepublished online 2012 Mar 16. doi: 10.1182/blood-2011-12-397729

PMCID:: PMC3369615

Abstract Article

Select item 299358314.

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Sara Gardenghi, Pedro Ramos, Maria Franca Marongiu, Luca Melchiori, Laura Breda, Ella Guy, Kristen Muirhead, Niva Rao, Cindy N. Roy, Nancy C. Andrews, Elizabeta Nemeth, Antonia Follenzi, Xiuli An, Narla Mohandas, Yelena Ginzburg, Eliezer A. Rachmilewitz, Patricia J. Giardina, Robert W. Grady, Stefano Rivella

J Clin Invest. 2010 Dec 1; 120(12): 4466–4477. Published online 2010 Nov 22. doi: 10.1172/JCI41717

PMCID:: PMC2993583

Abstract Article PDF–4.0M

Select item 116403615.

Mouse haemoglobin beta chains. Comparative sequence data on adult major and minor beta chains from two species, Mus musculus and Mus cervicolor.

J G Gilman

Biochem J. 1976 Oct 1; 159(1): 43–53. doi: 10.1042/bj1590043

PMCID:: PMC1164036

Summary Page Browse PDF–2.0M

Select item 3997416.

beta2 knockout mice develop parenchymal iron overload: A putative role for class I genes of the major histocompatibility complex in iron metabolism.

B E Rothenberg, J R Voland

Proc Natl Acad Sci U S A. 1996 Feb 20; 93(4): 1529–1534. doi: 10.1073/pnas.93.4.1529

PMCID:: PMC39974

Summary Page Browse PDF–2.3M

Select item 820548217.

The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry

Melanie Castro-Mollo, Sakshi Gera, Marc Ruiz-Martinez, Maria Feola, Anisa Gumerova, Marina Planoutene, Cara Clementelli, Veena Sangkhae, Carla Casu, Se-Min Kim, Vaughn Ostland, Huiling Han, Elizabeta Nemeth, Robert Fleming, Stefano Rivella, Daria Lizneva, Tony Yuen, Mone Zaidi, Yelena Ginzburg

eLife. 2021; 10: e68217. Published online 2021 May 18. doi: 10.7554/eLife.68217

PMCID:: PMC8205482

Abstract Article PDF–3.3M

Select item 792801518.

NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice

Antonella Nai, Maria Rosa Lidonnici, Giorgia Federico, Mariateresa Pettinato, Violante Olivari, Federica Carrillo, Simonetta Geninatti Crich, Giuliana Ferrari, Clara Camaschella, Laura Silvestri, Francesca Carlomagno

Haematologica. 2021 Mar 1; 106(3): 795–805. Published online 2020 Feb 27. doi: 10.3324/haematol.2019.241232

PMCID:: PMC7928015

Abstract Article PDF–2.1M

Select item 752066319.

Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition

Hussam Ghoti, Shanny Ackerman, Stefano Rivella, Carla Casu, Yona Nadir

Am J Pathol. 2020 Oct; 190(10): 2146–2154. doi: 10.1016/j.ajpath.2020.07.011

PMCID:: PMC7520663

Abstract Article PDF–1.5M

Select item 704659820.

Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia

João Arezes, Niall Foy, Kirsty McHugh, Doris Quinkert, Susan Benard, Anagha Sawant, Joe N. Frost, Andrew E. Armitage, Sant-Rayn Pasricha, Pei Jin Lim, May S. Tam, Edward Lavallie, Debra D. Pittman, Orla Cunningham, Matthew Lambert, John E. Murphy, Simon J. Draper, Reema Jasuja, Hal Drakesmith

Blood. 2020 Feb 20; 135(8): 547–557. Prepublished online 2020 Jan 3. doi: 10.1182/blood.2019003140

PMCID:: PMC7046598

Abstract Article

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