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Select item 92334401.

Disruption of Endosomal Sorting in Schwann Cells Leads to Defective Myelination and Endosomal Abnormalities Observed in Charcot-Marie-Tooth Disease

John W. McLean, Julie A. Wilson, Tina Tian, Jennifer A. Watson, Mary VanHart, Andrew J. Bean, Steven S. Scherer, David K. Crossman, Eroboghene Ubogu, Scott M. Wilson

J Neurosci. 2022 Jun 22; 42(25): 5085–5101. doi: 10.1523/JNEUROSCI.2481-21.2022

PMCID:: PMC9233440

Abstract Article PDF–4.2M

Select item 91521312.

Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradation

Veronica Birdsall, Konner Kirwan, Mei Zhu, Yuuta Imoto, Scott M Wilson, Shigeki Watanabe, Clarissa L Waites

Life Sci Alliance. 2022 Oct; 5(10): e202000745. Published online 2022 May 30. doi: 10.26508/lsa.202000745

PMCID:: PMC9152131

Abstract Article PDF–3.7M

Select item 48450153.

ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways

Ryuji Oshima, Takafumi Hasegawa, Keiichi Tamai, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Akio Kikuchi, Toru Baba, Akira Futatsugi, Ikuro Sato, Kennichi Satoh, Atsushi Takeda, Masashi Aoki, Nobuyuki Tanaka

Sci Rep. 2016; 6: 24997. Published online 2016 Apr 26. doi: 10.1038/srep24997

PMCID:: PMC4845015

Abstract Article PDF–2.8M

Select item 44664604.

Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility

Jicheng Chen, Ning Hou, Chong Zhang, Yan Teng, Xuan Cheng, Zhenhua Li, Jie Ren, Jian Zeng, Rui Li, Wei Wang, Xiao Yang, Yu Lan

Int J Biol Sci. 2015; 11(7): 794–802. Published online 2015 May 22. doi: 10.7150/ijbs.12248

PMCID:: PMC4466460

Abstract Article PDF–1.5M

Select item 26263915.

Loss of Hrs in the Central Nervous System Causes Accumulation of Ubiquitinated Proteins and Neurodegeneration

Keiichi Tamai, Masafumi Toyoshima, Nobuyuki Tanaka, Noriko Yamamoto, Yuji Owada, Hiroshi Kiyonari, Kazuko Murata, Yoshiyuki Ueno, Masao Ono, Tooru Shimosegawa, Nobuo Yaegashi, Masahiko Watanabe, Kazuo Sugamura

Am J Pathol. 2008 Dec; 173(6): 1806–1817. doi: 10.2353/ajpath.2008.080684

PMCID:: PMC2626391

Abstract Article PDF–1.3M

Select item 18006876.

Epidermal Growth Factor Receptor Fate Is Controlled by Hrs Tyrosine Phosphorylation Sites That Regulate Hrs Degradation

Kathryn A. Stern, Gina D. Visser Smit, Trenton L. Place, Stanley Winistorfer, Robert C. Piper, Nancy L. Lill

Mol Cell Biol. 2007 Feb; 27(3): 888–898. Published online 2006 Nov 13. doi: 10.1128/MCB.02356-05

PMCID:: PMC1800687

Abstract Article PDF–529K

Select item 64761357.

Syk and Hrs Regulate TLR3-Mediated Antiviral Response in Murine Astrocytes

Matylda B. Mielcarska, Magdalena Bossowska-Nowicka, Karolina P. Gregorczyk-Zboroch, Zbigniew Wyżewski, Lidia Szulc-Dąbrowska, Małgorzata Gieryńska, Felix N. Toka

Oxid Med Cell Longev. 2019; 2019: 6927380. Published online 2019 Apr 4. doi: 10.1155/2019/6927380

PMCID:: PMC6476135

Abstract Article PDF–3.8M

Select item 29551288.

Proteolytic processing of protocadherin proteins requires endocytosis

Sean M. Buchanan, Stefanie S. Schalm, Tom Maniatis

Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41): 17774–17779. Published online 2010 Sep 27. doi: 10.1073/pnas.1013105107

PMCID:: PMC2955128

Abstract Article PDF–570K

Select item 21727039.

Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes

Kristi G. Bache, Andreas Brech, Anja Mehlum, Harald Stenmark

J Cell Biol. 2003 Aug 4; 162(3): 435–442. doi: 10.1083/jcb.200302131

PMCID:: PMC2172703

Abstract Article PDF–428K

Select item 424608710.

ESCRT-0 Protein Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (Hrs) Is Targeted to Endosomes Independently of Signal-transducing Adaptor Molecule (STAM) and the Complex Formation with STAM Promotes Its Endosomal Dissociation

Katsuhiko Kojima, Yuji Amano, Kazuhisa Yoshino, Nobuyuki Tanaka, Kazuo Sugamura, Toshikazu Takeshita

J Biol Chem. 2014 Nov 28; 289(48): 33296–33310. Published online 2014 Oct 8. doi: 10.1074/jbc.M114.578245

Correction in:: J Biol Chem. 2015 Mar 27; 290(13): 8065–8066.

PMCID:: PMC4246087

Abstract Article PDF–3.2M

Select item 267657611.

Hybrid structural model of the complete human ESCRT-0 complex

Xuefeng Ren, Daniel P. Kloer, Young C. Kim, Rodolfo Ghirlando, Layla F. Saidi, Gerhard Hummer, James H. Hurley

Structure. Author manuscript; available in PMC 2010 Mar 11.

Published in final edited form as: Structure. 2009 Mar 11; 17(3): 406–416. doi: 10.1016/j.str.2009.01.012

PMCID:: PMC2676576

Abstract Article PDF–1.1M

Select item 297390312.

Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype

Xingshun Xu, Hao Yang, Yung-Feng Lin, Xiang Li, Austin Cape, Kerry J. Ressler, Shihua Li, Xiao-Jiang Li

Proc Natl Acad Sci U S A. 2010 Nov 2; 107(44): 19126–19131. Published online 2010 Oct 18. doi: 10.1073/pnas.1013032107

PMCID:: PMC2973903

Abstract Article PDF–762K

Select item 19655913.

STAM Proteins Bind Ubiquitinated Proteins on the Early Endosome via the VHS Domain and Ubiquitin-interacting Motif

Emi Mizuno, Kensuke Kawahata, Masaki Kato, Naomi Kitamura, Masayuki Komada

Mol Biol Cell. 2003 Sep; 14(9): 3675–3689. doi: 10.1091/mbc.E02-12-0823

PMCID:: PMC196559

Abstract Article PDF–1.3M

Select item 16463714.

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

Quan Lu, Lila Weiqiao Hope, Michael Brasch, Christoph Reinhard, Stanley N. Cohen

Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13): 7626–7631. Published online 2003 Jun 11. doi: 10.1073/pnas.0932599100

PMCID:: PMC164637

Abstract Article PDF–4.7M

Select item 294554615.

Hrs Controls Sorting of the Epithelial Na⁺ Channel between Endosomal Degradation and Recycling Pathways

Ruifeng Zhou, Rajesh Kabra, Diane R. Olson, Robert C. Piper, Peter M. Snyder

J Biol Chem. 2010 Oct 1; 285(40): 30523–30530. Published online 2010 Jul 30. doi: 10.1074/jbc.M110.150755

PMCID:: PMC2945546

Abstract Article PDF–2.2M

Select item 249337016.

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

Yoshinori Tanaka, Nobuyuki Tanaka, Yasushi Saeki, Keiji Tanaka, Masaaki Murakami, Toshio Hirano, Naoto Ishii, Kazuo Sugamura

Mol Cell Biol. 2008 Aug; 28(15): 4805–4818. Published online 2008 Jun 2. doi: 10.1128/MCB.01784-07

PMCID:: PMC2493370

Abstract Article PDF–1.5M

Select item 23087317.

Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain.

M Komada, N Kitamura

Mol Cell Biol. 1995 Nov; 15(11): 6213–6221. doi: 10.1128/mcb.15.11.6213

PMCID:: PMC230873

Summary PDF–782K

Select item 31676018.

Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis

Masayuki Komada, Philippe Soriano

Genes Dev. 1999 Jun 1; 13(11): 1475–1485. doi: 10.1101/gad.13.11.1475

PMCID:: PMC316760

Abstract Article PDF–2.1M

Select item 893524519.

Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis

Zhenhua Li, Tianle Wang, Chong Xin, Yao Song, Jingyi Kong, Jingping Xu, Qiqi Liu, Yan Teng, Ning Hou, Xuan Cheng, Guan Yang, Wenjia Liu, Bin Zhou, Youyi Zhang, Xiao Yang, Jian Wang

Int J Biol Sci. 2022; 18(5): 2018–2031. Published online 2022 Feb 28. doi: 10.7150/ijbs.69024

PMCID:: PMC8935245

Abstract Article PDF–2.3M

Select item 10219120.

Hgs (Hrs), a FYVE Domain Protein, Is Involved in Smad Signaling through Cooperation with SARA

Shigeto Miura, Toshikazu Takeshita, Hironobu Asao, Yutaka Kimura, Kazuko Murata, Yoshiteru Sasaki, Jun-Ichi Hanai, Hideyuki Beppu, Tomoo Tsukazaki, Jeffrey L. Wrana, Kohei Miyazono, Kazuo Sugamura

Mol Cell Biol. 2000 Dec; 20(24): 9346–9355. doi: 10.1128/mcb.20.24.9346-9355.2000