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Select item 106272931.

Interleukin-11 Suppresses Ocular Surface Inflammation and Accelerates Wound Healing

Aastha Singh, WonKyung J. Cho, Vinay K. Pulimamidi, Sharad K. Mittal, Sunil K. Chauhan

Invest Ophthalmol Vis Sci. 2023 Nov; 64(14): 1. Published online 2023 Nov 1. doi: 10.1167/iovs.64.14.1

PMCID:: PMC10627293

Abstract Article PDF–6.4M

Select item 105858092.

Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation

Xiaodong Zhu, Yu Zhao, Yuqiu Liu, Wen Shi, Junlan Yang, Zhihong Liu, Xiaoliang Zhang

Cell Commun Signal. 2023; 21: 293. Published online 2023 Oct 18. doi: 10.1186/s12964-023-01327-6

PMCID:: PMC10585809

Abstract Article PDF–11M

Select item 96916883.

Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis

Bingzi Dong, Masahiro Hiasa, Yoshiki Higa, Yukiyo Ohnishi, Itsuro Endo, Takeshi Kondo, Yuichi Takashi, Maria Tsoumpra, Risa Kainuma, Shun Sawatsubashi, Hiroshi Kiyonari, Go Shioi, Hiroshi Sakaue, Tomoki Nakashima, Shigeaki Kato, Masahiro Abe, Seiji Fukumoto, Toshio Matsumoto

Nat Commun. 2022; 13: 7194. Published online 2022 Nov 23. doi: 10.1038/s41467-022-34869-3

PMCID:: PMC9691688

Abstract Article PDF–3.9M

Select item 89990484.

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis

Benjamin Ng, Sivakumar Viswanathan, Anissa A. Widjaja, Wei-Wen Lim, Shamini G. Shekeran, Joyce Wei Ting Goh, Jessie Tan, Fathima Kuthubudeen, Sze Yun Lim, Chen Xie, Sebastian Schafer, Eleonora Adami, Stuart A. Cook

Int J Mol Sci. 2022 Apr; 23(7): 3549. Published online 2022 Mar 24. doi: 10.3390/ijms23073549

PMCID:: PMC8999048

Abstract Article PDF–3.8M

Select item 44403085.

Production of knockout mice by DNA microinjection of various CRISPR/Cas9 vectors into freeze-thawed fertilized oocytes

Yoshiko Nakagawa, Tetsushi Sakuma, Takuya Sakamoto, Masaki Ohmuraya, Naomi Nakagata, Takashi Yamamoto

BMC Biotechnol. 2015; 15: 33. Published online 2015 May 22. doi: 10.1186/s12896-015-0144-x

PMCID:: PMC4440308

Abstract Article PDF–2.4M

Select item 31376016.

Interleukin-11 Drives Early Lung Inflammation during Mycobacterium tuberculosis Infection in Genetically Susceptible Mice

Marina A. Kapina, Galina S. Shepelkova, Vadim G. Avdeenko, Anna N. Guseva, Tatiana K. Kondratieva, Vladimir V. Evstifeev, Alexander S. Apt

PLoS One. 2011; 6(7): e21878. Published online 2011 Jul 15. doi: 10.1371/journal.pone.0021878

PMCID:: PMC3137601

Abstract Article PDF–1.1M

Select item 112912887.

Inhibition of IL-11 signalling extends mammalian healthspan and lifespan

Anissa A. Widjaja, Wei-Wen Lim, Sivakumar Viswanathan, Sonia Chothani, Ben Corden, Cibi Mary Dasan, Joyce Wei Ting Goh, Radiance Lim, Brijesh K. Singh, Jessie Tan, Chee Jian Pua, Sze Yun Lim, Eleonora Adami, Sebastian Schafer, Benjamin L. George, Mark Sweeney, Chen Xie, Madhulika Tripathi, Natalie A. Sims, Norbert Hübner, Enrico Petretto, Dominic J. Withers, Lena Ho, Jesus Gil, David Carling, Stuart A. Cook

Nature. 2024; 632(8023): 157–165. Published online 2024 Jul 17. doi: 10.1038/s41586-024-07701-9

PMCID:: PMC11291288

Abstract Article PDF–19M

Select item 109147608.

ALKBH5-mediated m6A modification of IL-11 drives macrophage-to-myofibroblast transition and pathological cardiac fibrosis in mice

Tao Zhuang, Mei-Hua Chen, Ruo-Xi Wu, Jing Wang, Xi-De Hu, Ting Meng, Ai-Hua Wu, Yan Li, Yong-Feng Yang, Yu Lei, Dong-Hua Hu, Yan-Xiu Li, Li Zhang, Ai-Jun Sun, Wei Lu, Guan-Nan Zhang, Jun-Li Zuo, Cheng-Chao Ruan

Nat Commun. 2024; 15: 1995. Published online 2024 Mar 5. doi: 10.1038/s41467-024-46357-x

Correction in:: Nat Commun. 2024; 15: 5595.

PMCID:: PMC10914760

Abstract Article PDF–5.6M

Select item 101577419.

IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer

Qian Zhao, Lu Qian, Yuefan Guo, Jinhui Lü, Danni Li, Heying Xie, Qiong Wang, Wenjing Ma, Pengfei Liu, Yu Liu, Tao Wang, Xuebiao Wu, Junyi Han, Zuoren Yu

Theranostics. 2023; 13(7): 2337–2349. Published online 2023 Apr 17. doi: 10.7150/thno.82538

PMCID:: PMC10157741

Abstract Article PDF–6.8M

Select item 972312010.

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease

Anissa A. Widjaja, Sivakumar Viswanathan, Shamini G. Shekeran, Eleonora Adami, Wei-Wen Lim, Sonia Chothani, Jessie Tan, Joyce Wei Ting Goh, Hui Mei Chen, Sze Yun Lim, Carine M. Boustany-Kari, Julie Hawkins, Enrico Petretto, Norbert Hübner, Sebastian Schafer, Thomas M. Coffman, Stuart A. Cook

Nat Commun. 2022; 13: 7497. Published online 2022 Dec 5. doi: 10.1038/s41467-022-35306-1

PMCID:: PMC9723120

Abstract Article PDF–7.9M

Select item 938190611.

Sirt1 overexpression improves senescence‐associated pulmonary fibrosis induced by vitamin D deficiency through downregulating IL‐11 transcription

Jiawen Zhou, Haiyun Chen, Qiuyi Wang, Sihan Chen, Rong Wang, Ziyang Wang, Cuicui Yang, Ao Chen, Jingyu Zhao, Zihao Zhou, Zhiyuan Mao, Guoping Zuo, Dengshun Miao, Jianliang Jin

Aging Cell. 2022 Aug; 21(8): e13680. Published online 2022 Jul 30. doi: 10.1111/acel.13680

PMCID:: PMC9381906

Abstract Article PDF–16M

Select item 847502912.

Krüppel‐Like Factor 15/Interleukin 11 Axis‐Mediated Adventitial Remodeling Depends on Extracellular Signal‐Regulated Kinases 1 and 2 Activation in Angiotensin II–Induced Hypertension

Yue‐Tong Guo, Yuan‐Yuan Lu, Xiao Lu, Shun He, Shi‐Jin Li, Shuai Shao, Han‐Dan Zhou, Rui‐Qi Wang, Xiao‐Dong Li, Ping‐Jin Gao

J Am Heart Assoc. 2021 Aug 17; 10(16): e020554. Published online 2021 Aug 5. doi: 10.1161/JAHA.120.020554

PMCID:: PMC8475029

Abstract Article PDF–3.1M

Select item 826681313.

Benjamin Ng, Anissa A. Widjaja, Sivakumar Viswanathan, Jinrui Dong, Sonia P. Chothani, Stella Lim, Shamini G. Shekeran, Jessie Tan, Narelle E. McGregor, Emma C. Walker, Natalie A. Sims, Sebastian Schafer, Stuart A. Cook

Sci Rep. 2021; 11: 14088. Published online 2021 Jul 8. doi: 10.1038/s41598-021-93623-9

PMCID:: PMC8266813

Abstract Article PDF–7.3M

Select item 470298314.

Interleukin-11 alters placentation and causes preeclampsia features in mice

Amy L. Winship, Kaori Koga, Ellen Menkhorst, Michelle Van Sinderen, Katarzyna Rainczuk, Miwako Nagai, Carly Cuman, Joanne Yap, Jian-Guo Zhang, David Simmons, Morag J. Young, Evdokia Dimitriadis

Proc Natl Acad Sci U S A. 2015 Dec 29; 112(52): 15928–15933. Published online 2015 Dec 11. doi: 10.1073/pnas.1515076112

PMCID:: PMC4702983

Abstract Article PDF–1.3M

Select item 442269415.

IL-11 Attenuates Liver Ischemia/Reperfusion Injury (IRI) through STAT3 Signaling Pathway in Mice

Miao Zhu, Bo Lu, Qinhong Cao, Zhenfeng Wu, Zhe Xu, Weisu Li, Xuequan Yao, Fukun Liu

PLoS One. 2015; 10(5): e0126296. Published online 2015 May 6. doi: 10.1371/journal.pone.0126296

PMCID:: PMC4422694

Abstract Article PDF–14M

Select item 302713916.

Interleukin-11 regulates autoimmune demyelination

Blake T. Gurfein, Yueting Zhang, Carolina B. López, Azeb Tadesse Argaw, Andleeb Zameer, Thomas M. Moran, Gareth R. John

J Immunol. Author manuscript; available in PMC 2011 Jan 26.

Published in final edited form as: J Immunol. 2009 Oct 1; 183(7): 4229–4240. Published online 2009 Sep 4. doi: 10.4049/jimmunol.0900622

PMCID:: PMC3027139

Abstract Article PDF–3.3M

Select item 294752217.

Mechanical Stress Activates Smad Pathway through PKCδ to Enhance Interleukin-11 Gene Transcription in Osteoblasts

Shinsuke Kido, Rika Kuriwaka-Kido, Yuka Umino-Miyatani, Itsuro Endo, Daisuke Inoue, Hisaaki Taniguchi, Yasumichi Inoue, Takeshi Imamura, Toshio Matsumoto

PLoS One. 2010; 5(9): e13090. Published online 2010 Sep 29. doi: 10.1371/journal.pone.0013090

PMCID:: PMC2947522

Abstract Article PDF–1.5M

Select item 1045567718.

Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction

Mark Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes, Ekhlas Rahman, Michael Lee, Konstantinos Vanezis, Ivan Andrew, Wei-Wen Lim, Anissa Widjaja, Paul J. R. Barton, Stuart A. Cook

Int J Mol Sci. 2023 Aug; 24(16): 12989. Published online 2023 Aug 20. doi: 10.3390/ijms241612989

PMCID:: PMC10455677

Abstract Article PDF–3.0M

Select item 1024467219.

IL11 activates the placental inflammasome to drive preeclampsia

Ellen Menkhorst, Leilani L. Santos, Wei Zhou, Guannan Yang, Amy L. Winship, Katarzyna E. Rainczuk, Philana Nguyen, Jian-Guo Zhang, Paddy Moore, Michelle Williams, Kim-Anh Lê Cao, Ashley Mansell, Evdokia Dimitriadis

Front Immunol. 2023; 14: 1175926. Published online 2023 May 24. doi: 10.3389/fimmu.2023.1175926

PMCID:: PMC10244672

Abstract Article PDF–15M

Select item 1012513020.

IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome

Benjamin Ng, Chen Xie, Liping Su, Fathima F. Kuthubudeen, Xiu-Yi Kwek, Daryl Yeong, Chee Jian Pua, Stuart A. Cook, Wei-Wen Lim

Arterioscler Thromb Vasc Biol. 2023 May; 43(5): 739–754. Published online 2023 Apr 27. doi: 10.1161/ATVBAHA.122.318802

PMCID:: PMC10125130

Abstract Article PDF–6.9M

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